Georgy Belogurov
PhD
gebelo@utu.fi +358 29 450 4775 +358 50 475 7149 Tykistökatu 6 Turku Office: 6057 ORCID identifier: https://orcid.org/0000-0002-3070-6843 |
Areas of expertise
Transcription, nucleic acids enzymes, enzyme kinetics, protein chemistry, molecular modeling, nucleoside analogue inhibitors, phylogenomics.
Transcription, nucleic acids enzymes, enzyme kinetics, protein chemistry, molecular modeling, nucleoside analogue inhibitors, phylogenomics.
Biography
Ph.D. - University of Turku, Dept. of Biochemistry, Finland, 2005
Postdoc - Ohio State Univesity, Dept. of Microbiology, USA, 2006-2009
Principal investigator - University of Turku, Dept. of Biochemistry, Finland, 2009-2020
Principal investigator - University of Turku, Dept. of Life Technologies, Finland, 2020-
Associate Professor - University of Turku, Dept. of Life Technologies, Finland, 2023-
Research
The properties of a cell are determined by the information encoded in its genome. Understanding how such information is differentially and dynamically retrieved in response to environmental changes and cellular needs is a major challenge facing molecular biology. The focal point of our research is a multisubunit RNA polymerase, the enzyme that carries out the first step in gene expression, synthesis of RNA. We study several classes of RNA polymerases with the aim of understanding the fundamental aspects of transcription regulation, catalytic mechanism, and developing medically relevant transcription inhibitors.
Teaching
Molecular Biology, Bioproduction, Bioinformatics, Enzyme kinetics
Publications 
2 of 3
- RNA polymerase gate loop guides the nontemplate DNA strand in transcription complexes (2016)
- Proceedings of the National Academy of Sciences of the United States of America
(A1 Refereed original research article in a scientific journal) - Creative Math of RNA Polymerase III Termination: Sense Plus Antisense Makes More Sense (2015)
- Molecular Cell
(A1 Refereed original research article in a scientific journal) - Monitoring translocation of multisubunit RNA polymerase along the DNA with fluorescent base analogues (2015) Bacterial Transcriptional Control Malinen Anssi M., Turtola Matti, Belogurov Georgiy A.
(A3 Refereed book chapter or chapter in a compilation book) - Regulation of Transcript Elongation (2015)
- Annual Review of Microbiology
(A2 Refereed review article in a scientific journal ) - CBR antimicrobials alter coupling between the bridge helix and the β subunit in RNA polymerase (2014)
- Nature Communications
(A1 Refereed original research article in a scientific journal) - Tracing the Evolution of Angucyclinone Monooxygenases: Structural Determinants for C-12b Hydroxylation and Substrate Inhibition in PgaE (2013)
- Biochemistry
(A1 Refereed original research article in a scientific journal) - Active site opening and closure control translocation of multisubunit RNA polymerase (2012)
- Nucleic Acids Research
(A1 Refereed original research article in a scientific journal) - Na+-translocating Membrane Pyrophosphatases Are Widespread in the Microbial World and Evolutionarily Precede H+-translocating Pyrophosphatases (2011)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal) - The beta Subunit Gate Loop Is Required for RNA Polymerase Modification by RfaH and NusG (2011)
- Molecular Cell
(A1 Refereed original research article in a scientific journal) - Functional regions of the N-terminal domain of the antiterminator RfaH (2010)
- Molecular Microbiology
(A1 Refereed original research article in a scientific journal) - Functional specialization of transcription elongation factors (2009)
- EMBO Journal
(A1 Refereed original research article in a scientific journal) - Transcription inactivation through local refolding of the RNA polymerase structure (2009)
- Nature
(A1 Refereed original research article in a scientific journal) - A CBS domain-containing pyrophosphatase of Moorella thermoacetica is regulated by adenine nucleotides. (2007)
- Biochemical Journal
(A1 Refereed original research article in a scientific journal) - Allosteric control of the RNA polymerase by the elongation factor RfaH (2007)
- Nucleic Acids Research
(A1 Refereed original research article in a scientific journal) - Na+-pyrophosphatase: A novel primary sodium pump (2007)
- Biochemistry
(A1 Refereed original research article in a scientific journal) - Structural basis for converting a general transcription factor into an operon-specific virulence regulator (2007)
- Molecular Cell
(A1 Refereed original research article in a scientific journal) - Two soluble pyrophosphatases in Vibrio cholerae: Transient redundancy or enduring cooperation? (2006)
- Биохимия / Biochemistry
(A1 Refereed original research article in a scientific journal) - Membrane-bound pyrophosphatase of Thermotoga maritima requires sodium for activity (2005)
- Biochemistry
(A1 Refereed original research article in a scientific journal) - Elucidating the role of conserved glutamates in H+-pyrophosphatase of Rhodospirillum rubrum (2004)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal) - A lysine substitute for K+. A460K mutation eliminates K+ dependence in H+-pyrophosphatase of Carboxydothermus hydrogenoformans. (2002)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal)
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