Kati Elima
M.D., Ph.D., Adjunct professor
kateli@utu.fi +358 29 450 2325 +358 50 472 5500 Kiinamyllynkatu 10 Turku |
Molecular mechanisms of cell trafficking; medical education; postgraduate education
Molecular mechanisms of cell trafficking; Immunology and cancer biology
Degrees and competences
- Licenciate of Medicine, 1988, University of Turku, Finland; Doctor of Medical Sciences (M.D., Ph.D.) 1990, University of Turku; Docent in Molecular Medicine, University of Turku.
- Specialist Qualification in Management 2007; General teacher qualification (university pedagogics 60 ECTS), 2014, University of Turku; Special Competence in Medical Education, 2014; Training in practical academic leadership, 2017, TSE
Current tasks
- Clinical lecturer in Molecular Medicine
- Director of Research Track in Molecular Medicine
- Deputy director of Institute of Biomedicine (education)
Previous
- University of Turku: various research and teaching positions at the Department of Medical Biochemistry and Genetics, Faculty of Medicine (assistant, university teacher, clinical lecturer, associate professor, professor)
- National Institute of Health and Welfare: special investigator
- Academy of Finland: research programme coordinator
- Turku Graduate School of Biomedical Sciences (TuBS): coordinator
Lymphatic and vascular endothelium plays a pivotal role in leukocyte and cancer cell migration by expressing counter-receptors for the cell-surface molecules on the migrating cells that mediate trafficking. My research focuses on investigating the molecular mechanisms underlying these interactions and studying the functional role of the individual molecules in various disease processes. Special emphasis is on the roles of the large, multi-domain cell-surface molecule CLEVER-1, and the ecto-enzymes VAP-1 and CD73 in various human cancers.
Interest areas:
- Medical education; molecular medicine; genome medicine;
Teaching responsibilities:
- Medical Biochemistry and Molecular Medicine
- Research Track in Molecular Medicine
- Postgraduate education (doctoral programmes and InFLAMES Flagship)
Other:
- The Finnish Medical Society Duodecim: Head of education at the Turku region
- Polymorphism in interferon alpha/beta receptor contributes to glucocorticoid response and outcome of ARDS and COVID-19 (2023)
- Critical Care
- Lymphatic Endothelial Cell Activation and Dendritic Cell Transmigration Is Modified by Genetic Deletion of Clever-1 (2021)
- Frontiers in Immunology
- Effect of Intravenous Interferon β-1a on Death and Days Free from Mechanical Ventilation among Patients with Moderate to Severe Acute Respiratory Distress Syndrome: A Randomized Clinical Trial (2020)
- JAMA: Journal of the American Medical Association
for the INTEREST Study Group - Fetal-derived macrophages persist and sequentially maturate in ovaries after birth in mice (2020)
- European Journal of Immunology
- Robo4 contributes to the turnover of Peyer’s patch B cells (2020)
- Mucosal Immunology
- Fenestral diaphragms and PLVAP associations in liver sinusoidal endothelial cells are developmentally regulated (2019)
- Scientific Reports
- Fetal-derived macrophages dominate in adult mammary glands (2019)
- Nature Communications
- Enhanced Antibody Production in Clever-1/Stabilin-1-Deficient Mice (2018)
- Frontiers in Immunology
- Amine oxidase activity regulates the development of pulmonary fibrosis (2017)
- FASEB Journal
- Fetal liver endothelium regulates the seeding of tissue-resident macrophages (2016)
- Nature
- Gene-expression profiling of different arms of lymphatic vasculature identifies candidates for manipulation of cell traffic (2016)
- Proceedings of the National Academy of Sciences of the United States of America
- Monocyte stabilin-1 suppresses the activation of Th1 lymphocytes (2016)
- Journal of Immunology
- Stabilin-1 expression defines a subset of macrophages that mediate tissue homeostasis and prevent fibrosis in chronic liver injury (2016)
- Proceedings of the National Academy of Sciences of the United States of America
- Ecto-5'-nucleotidase/CD73 enhances endothelial barrier function and sprouting in blood but not lymphatic vasculature (2015)
- European Journal of Immunology
- Primary Amine Oxidase of Escherichia coli Is a Metabolic Enzyme that Can Use a Human Leukocyte Molecule as a Substrate (2015)
- PLoS ONE
- The endothelial protein PLVAP in lymphatics controls the entry of lymphocytes and antigens into lymph nodes (2015)
- Nature Immunology
- Adenosine Inhibits Tumor Cell Invasion via Receptor-Independent Mechanisms. (2014)
- Molecular Cancer Research
- Clever-1/stabilin-1 controls cancer growth and metastasis (2014)
- Clinical Cancer Research
- Consequences of the Lack of CD73 and Prostatic Acid Phosphatase in the Lymphoid Organs (2014)
- Mediators of Inflammation
- Early prediction of persistent organ failure by soluble CD73 in patients with acute pancreatitis (2014)
- Critical Care Medicine