Teijo Saari
MD, PhD. Head of Department
Pain medicine; Analgesia; Modelling & Simulation; Pharmacometrics; Clinical Pharmacology; Drug-Drug-Interactions
Precise and new therapeutic possibilities to acute pain medicine. Prevention of subsequent subacute pain and development chronic pain
Professor Teijo Saari (MD, PhD, University of Turku) is a specialist in anesthesiology and intensive care and cardiac anesthesia at the Turku University Hospital, Turku, Finland. Since 2004, he has been conducting research on clinical pharmacology examining the pain therapeutics and anesthetics and developing pharmacometric models for precise drug dosing. His PhD work evaluated drug-drug interactions between antimycotes and drugs used in anesthesiology and pain medicine (University of Turku, April 2005). In 2011-2013 he worked as post doctoral fellow in University of Erlangen-Nuremberg, Germany in pharmacometric research project: ’PEP’ – Personalized Effect-Controlled Pharmacotherapy. Since 2013, he has lead his research group focusing on acute pain medicine. In January 2017, he was appointed to Tenure Track as Associate Professor and in June 2021 as Full Professor and Chairman of Anesthesiology and Intensive Care at the University of Turku.
His career publications total is 64 (h-index 26) with published highlights including high-ranked papers in Anesthesiology, British Journal of Anesthesiology and Clinical Pharmacokinetics.
Professor Saari's principal research focus has been to provide novel information on therapeutics used in acute pain medicine. Beginning from 2013 he has led a research group with special interest on model-informed precision dosing and development of new dosing modalities for pain therapeutics. Important aspect of his research has been a pursuit to reduce opioid use with adjuvants added to the opioid therapy in the postoperative setting. His work has demonstrated that pharmacometric models can improve the precision of drug dosing during postoperative phase. Furthermore, his studies have established covariate effects explaining between-patient variability. His future aim is to discover biomarkers that can predict chronic pain development.
Teaching responsibilities: 1) Anesthesiology and Intensive care for medical students, 2) Graduate studies for MDs
Special interest areas: Acute pain medicine, cardiac anesthesia, clinical pharmacology
- Tulehduskipulääkkeet ja parasetamoli (2021) Anestesiologia, teho-, ensi- ja kivunhoito Salomäki Timo, Saari Teijo
- Tulehduskipulääkkeiden kliininen käyttö (2021) Anestesiologia, teho-, ensi- ja kivunhoito Salomäki Timo, Saari Teijo
- Tulehduskipulääkkeiden vaikutusmekanismi (2021) Anestesiologia, teho-, ensi- ja kivunhoito Salomäki Timo, Saari Teijo
- A Physiologically Based Pharmacokinetic Model of Voriconazole Integrating Time-Dependent Inhibition of CYP3A4, Genetic Polymorphisms of CYP2C19 and Predictions of Drug–Drug Interactions (2020)
- Clinical Pharmacokinetics
- Autismikirjon potilaiden anestesia (2020)
- Finnanest
- Cerebral autoregulation after aneurysmal subarachnoid haemorrhage. A preliminary study comparing dexmedetomidine to propofol and/or midazolam (2020)
- Acta Anaesthesiologica Scandinavica
- Deksmedetomidiinin uudet antamistavat laajentavat käyttöaiheita tehohoitosedaation ulkopuolelle (2020)
- Duodecim
- Feasibility of a transmucosal sublingual fentanyl tablet as a procedural pain treatment in colonoscopy patients: a prospective placebo-controlled randomized study (2020)
- Scientific Reports
- Ketamiini leikkauksen jälkeisen kivun hoidossa (2020)
- Spirium
- Ketamine Pharmacokinetics: A Systematic Review of the Literature, Meta-analysis, and Population Analysis (2020)
- Anesthesiology
- Pharmacokinetics and Sedative Effects of Intranasal Dexmedetomidine in Ambulatory Pediatric Patients (2020)
- Anesthesia and Analgesia
- Population Modelling of Dexmedetomidine Pharmacokinetics and Haemodynamic Effects After Intravenous and Subcutaneous Administration (2020)
- Clinical Pharmacokinetics
- Intranasal low-dose dexmedetomidine reduces postoperative opioid requirement in patients undergoing hip arthroplasty under general anesthesia (2019)
- Journal of Arthroplasty
- Kolmannes ensihoitajien konsultaatioista jää lääkäreiltä kirjaamatta (2019)
- Lääkärilehti
- Opin edelleen (2019)
- Finnanest
- Premedication with intranasal dexmedetomidine decreases thiopental requirements in sedation of pediatric patients for magnetic resonance imaging: a retrospective study (2019)
- BMC Anesthesiology
- Deksmedetomidiinin intranasaalinen annostelu (2018)
- Finnanest
- Semimechanistic Population Pharmacokinetic Model to Predict the Drug–Drug Interaction Between S-ketamine and Ticlopidine in Healthy Human Volunteers (2018)
- CPT: Pharmacometrics and Systems Pharmacology
- Sequential Organ Failure Assessment (SOFA) to Predict Pressure Ulcer Risk in Intensive Care Patients: A Retrospective Cohort Study (2018)
- Ostomy Wound Management
- Subcutaneously administered dexmedetomidine is efficiently absorbed and is associated with attenuated cardiovascular effects in healthy volunteers (2018)
- European Journal of Clinical Pharmacology