Teijo Saari
MD, PhD. Head of Department
teisaa@utu.fi ORCID identifier: https://orcid.org/0000-0003-1225-4561 |
Pain medicine; Analgesia; Modelling & Simulation; Pharmacometrics; Clinical Pharmacology; Drug-Drug-Interactions
Precise and new therapeutic possibilities to acute pain medicine. Prevention of subsequent subacute pain and development chronic pain
Professor Teijo Saari (MD, PhD, University of Turku) is a specialist in anesthesiology and intensive care and cardiac anesthesia at the Turku University Hospital, Turku, Finland. Since 2004, he has been conducting research on clinical pharmacology examining the pain therapeutics and anesthetics and developing pharmacometric models for precise drug dosing. His PhD work evaluated drug-drug interactions between antimycotes and drugs used in anesthesiology and pain medicine (University of Turku, April 2005). In 2011-2013 he worked as post doctoral fellow in University of Erlangen-Nuremberg, Germany in pharmacometric research project: ’PEP’ – Personalized Effect-Controlled Pharmacotherapy. Since 2013, he has lead his research group focusing on acute pain medicine. In January 2017, he was appointed to Tenure Track as Associate Professor and in June 2021 as Full Professor and Chairman of Anesthesiology and Intensive Care at the University of Turku.
His career publications total is 64 (h-index 26) with published highlights including high-ranked papers in Anesthesiology, British Journal of Anesthesiology and Clinical Pharmacokinetics.
Professor Saari's principal research focus has been to provide novel information on therapeutics used in acute pain medicine. Beginning from 2013 he has led a research group with special interest on model-informed precision dosing and development of new dosing modalities for pain therapeutics. Important aspect of his research has been a pursuit to reduce opioid use with adjuvants added to the opioid therapy in the postoperative setting. His work has demonstrated that pharmacometric models can improve the precision of drug dosing during postoperative phase. Furthermore, his studies have established covariate effects explaining between-patient variability. His future aim is to discover biomarkers that can predict chronic pain development.
Teaching responsibilities: 1) Anesthesiology and Intensive care for medical students, 2) Graduate studies for MDs
Special interest areas: Acute pain medicine, cardiac anesthesia, clinical pharmacology
- Rifampicin markedly decreases the exposure to oral and intravenous tramadolInteraction of oxycodone and voriconazole-a case series of patients with cancer pain supports the findings of randomised controlled studies with healthy subjects (2013)
- European Journal of Clinical PharmacologyClinical Drug Investigation
(A1 Refereed original research article in a scientific journal) - Ticlopidine inhibits both O-demethylation and renal clearance of tramadol, increasing the exposure to it, but itraconazole has no marked effect on the ticlopidine-tramadol interactionMiconazole Oral Gel Increases Exposure to Oral Oxycodone by Inhibition of CYP2D6 and CYP3A4 (2013)
- European Journal of Clinical Pharmacology
(A1 Refereed original research article in a scientific journal) - Analysis of total and unbound hydromorphone in human plasma by ultrafiltration and LC-MS/MS: Application to clinical trial in patients undergoing open heart surgery (2012)
- Journal of Pharmaceutical and Biomedical AnalysisCurrent Opinion in Anaesthesiology
(A1 Refereed original research article in a scientific journal) - Changes in total and unbound concentrations of sufentanil during target controlled infusion for cardiac surgery with cardiopulmonary bypassEnhancement of GABAergic Activity: Neuropharmacological Effects of Benzodiazepines and Therapeutic Use in Anesthesiology (2012)
- British Journal of AnaesthesiaPharmacological Reviews
(A1 Refereed original research article in a scientific journal) - Determination of total and unbound sufentanil in human plasma by ultrafiltration and LC-MS/MS: Application to clinical pharmacokinetic study (2012)
- Journal of Pharmaceutical and Biomedical Analysis
(A1 Refereed original research article in a scientific journal) - Dexmedetomidin – Pharmacokinetics and pharmacodynamics (2012)
- AnaesthesistClinical Pharmacology and TherapeuticsJournal of Clinical Pharmacology
(A1 Refereed original research article in a scientific journal) - Oxycodone clearance is markedly reduced with advancing age: a population pharmacokinetic study (2012)
- British Journal of AnaesthesiaEuropean Journal of Clinical Pharmacology
(A1 Refereed original research article in a scientific journal) - Re: Pergolizzi et al. 2011: Exposure to potential CYP450 pharmacokinetic drug-drug interactions (2012)
- Pain PracticeAntimicrobial Agents and Chemotherapy
(B1 Non-refereed article in a scientific journal) - Rifampicin has a Profound Effect on the Pharmacokinetics of Oral S-Ketamine and Less on Intravenous S-Ketamine (2012)
- Basic and Clinical Pharmacology and Toxicology. Supplement
(A1 Refereed original research article in a scientific journal) - S-ketamine concentrations are greatly increased by grapefruit juice (2012)
- European Journal of Clinical Pharmacology
(A1 Refereed original research article in a scientific journal) - St John's wort greatly decreases the plasma concentrations of oral S-ketamine (2012)
- Fundamental and Clinical Pharmacology
(A1 Refereed original research article in a scientific journal) - Effect of Inhibition of Cytochrome P450 Enzymes 2D6 and 3A4 on the Pharmacokinetics of Intravenous Oxycodone A Randomized, Three-Phase, Crossover, Placebo-Controlled Study (2011)
(A1 Refereed original research article in a scientific journal) - Enhancement of GABAergic activity:neuropharmacological effects of benzodiazepines and therapeutic use in anaesthesiology (2011)
- Pharmacological Reviews
(A2 Refereed review article in a scientific journal ) - (2011)
(A1 Refereed original research article in a scientific journal) - Exposure to Oral S-ketamine Is Unaffected by Itraconazole but Greatly Increased by Ticlopidine (2011)
(A1 Refereed original research article in a scientific journal) - (2011)
(A1 Refereed original research article in a scientific journal) - (2011)
(A1 Refereed original research article in a scientific journal) - Azole antimycotics and drug interactions in the perioperative period (2010)
(A2 Refereed review article in a scientific journal ) - Clarithromycin, a potent inhibitor of CYP3A, greatly increases exposure to oral S-ketamine (2010)
- European Journal of Pain
(A1 Refereed original research article in a scientific journal) - Effect of Telithromycin on the Pharmacokinetics and Pharmacodynamics of Oral Oxycodone (2010)
(A1 Refereed original research article in a scientific journal)



