Michael Courtney

- Senior Research Fellow,
Turku Bioscience Centre (Independent units)

miccou@utu.fi

+358 29 450 3739

+358 50 464 9827

Tykistökatu 6

Turku

ORCID identifier: https://orcid.org/0000-0001-8693-3933

Areas of expertise

protein interactions; cell signalling; cell imaging; optical assays; single-cell methods; optogenetics; protein engineering; neuroscience; reporter design; AAV; assay development; drug discovery; compound screening; high-throughput methods; high-content analysis; lab automation

Publications

2 of 3

Calpains Are Downstream Effectors of bax-Dependent Excitotoxic Apoptosis (2012)
- Journal of Neuroscience
D'Orsi B, Bonner H, Tuffy LP, Dussmann H, Woods I, Courtney MJ, Ward MW, Prehn JHM
(A1 Refereed original research article in a scientific journal)
c-Jun N-Terminal Kinase Phosphorylation of MARCKSL1 Determines Actin Stability and Migration in Neurons and in Cancer Cells (2012)
- Molecular and Cellular Biology
Bjorkblom B, Padzik A, Mohammad H, Westerlund N, Komulainen E, Hollos P, Parviainen L, Papageorgiou AC, Iljin K, Kallioniemi O, Kallajoki M, Courtney MJ, Magard M, James P, Coffey ET
(A1 Refereed original research article in a scientific journal)
Hippocampal long-term depression is enhanced, depotentiation is inhibited and long-term potentiation is unaffected by the application of a selective c-Jun N-terminal kinase inhibitor to freely behaving rats (2011)
- European Journal of Neuroscience
Yang HH, Courtney MJ, Martinsson P, Manahan-Vaughan D
(A1 Refereed original research article in a scientific journal)
Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and neuronal migration rate (2011)
- Nature Neuroscience
Westerlund N, Zdrojewska J, Padzik A, Komulainen E, Björkblom B, Rannikko E, Tararuk T, Garcia-Frigola C, Sandholm J, Nguyen L, Kallunki T, Courtney MJ, Coffey ET
(A1 Refereed original research article in a scientific journal)
Concurrent protective and destructive signaling of JNK2 in neuroblastoma cells (2009)
- Cellular Signalling
Waetzig V, Wacker U, Haeusgen W, Bjorkblom B, Courtney MJ, Coffey ET, Herdegen T
(A1 Refereed original research article in a scientific journal)
All JNKs can kill, but nuclear localization is critical for neuronal death (2008)
- Journal of Biological Chemistry
Bjorkblom B, Vainio JC, Hongisto V, Herdegen T, Courtney MJ, Coffey ET
(A1 Refereed original research article in a scientific journal)
Real time analysis of tumor necrosis factor-related apoptosis-inducing ligand/cycloheximide-induced caspase activities during apoptosis initiation (2008)
- Journal of Biological Chemistry
Hellwig CT, Kohler BF, Lehtivarjo AK, Dussmann H, Courtney MJ, Prehn JHM, Rehm M
(A1 Refereed original research article in a scientific journal)
Superior cervical ganglion-10 protein as a molecular effector of c-Jun N-terminal kinase 1: implications for the therapeutic targeting of Jun N-terminal kinase in nerve regeneration (2008)
- Expert Opinion on Therapeutic Targets
Westerlund N, Zdrojewska J, Courtney MJ, Coffey ET
(A1 Refereed original research article in a scientific journal)
The Wnt pool of glycogen synthase kinase 3 beta is critical for trophic-deprivation-induced neuronal death (2008)
- Molecular and Cellular Biology
Hongisto V, Vainio JC, Thompson R, Courtney MJ, Coffey ET
(A1 Refereed original research article in a scientific journal)
Rho mediates calcium-dependent activation of p38 alpha and subsequent excitotoxic cell death (2007)
- Nature Neuroscience
Semenova MM, Maki-Hokkonen AMJ, Cao J, Komarovski V, Forsberg KM, Koistinaho M, Coffey ET, Courtney MJ
(A1 Refereed original research article in a scientific journal)
JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length (2006)
- Journal of Cell Biology
Tararuk T, Ostman N, Li WR, Bjorkblom B, Padzik A, Zdrojewska J, Hongisto V, Herdegen T, Konopka W, Courtney MJ, Coffey ET
(A1 Refereed original research article in a scientific journal)
JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length (vol 173, pg 265, 2006) (2006)
- Journal of Cell Biology
Tararuk T, Ostman N, Li WR, Bjorkblom B, Padzik A, Zdrojewska J, Hongisto V, Herdegen T, Konopka W, Courtney MJ, Coffey ET
(A1 Refereed original research article in a scientific journal)
Constitutively active cytoplasmic c-Jun N-terminal kinase 1 is a dominant regulator of dendritic architecture: Role of microtubule-associated protein 2 as an effector (2005)
- Journal of Neuroscience
Bjorkblom B, Ostman N, Hongisto V, Komarovski V, Filen JJ, Nyman TA, Kallunki T, Courtney MJ, Coffey ET
(A1 Refereed original research article in a scientific journal)
The PSD95-nNOS interface: a target for inhibition of excitotoxic p38 stress-activated protein kinase activation and cell death (2005)
- Journal of Cell Biology
Cao J, Viholainen JI, Dart C, Warwick HK, Leyland ML, Courtney MJ
(A1 Refereed original research article in a scientific journal)
Ca2+-dependent potentiation of muscarinic receptor-mediated Ca2+ elevation (2004)
- Cell Calcium
Akerman KEO, Shariatmadari R, Krjukova J, Larsson KP, Courtney MJ, Kukkonen JP
(A1 Refereed original research article in a scientific journal)
Distinct requirements for p38 alpha and c-jun N-terminal kinase stress-activated protein kinases in different forms of apoptotic neuronal death (2004)
- Journal of Biological Chemistry
Cao J, Semenova MM, Solovyan VT, Han JH, Coffey ET, Courtney MJ
(A1 Refereed original research article in a scientific journal)
Heat stress downregulates FLIP and sensitizes cells to Fas receptor-mediated apoptosis (2003)
- Cell Death and Differentiation
Tran SEF, Meinander A, Holmstrom TH, Rivero-Muller A, Heiskanen KM, Linnau EK, Courtney MJ, Mosser DD, Sistonen L, Eriksson JE
(A1 Refereed original research article in a scientific journal)
Lithium blocks the c-Jun stress response and protects neurons via its action on glycogen synthase kinase 3 (2003)
- Molecular and Cellular Biology
Hongisto V, Smeds N, Brecht S, Herdegen T, Courtney MJ, Coffey ET
(A1 Refereed original research article in a scientific journal)
c-Jun N-terminal protein kinase (JNK) 2/3 is specifically activated by stress, mediating c-Jun activation, in the presence of constitutive JNK1 activity in cerebellar neurons (2002)
- Journal of Neuroscience
Coffey ET, Smiciene G, Hongisto V, Cao J, Brecht S, Herdegen T, Courtney MJ
(A1 Refereed original research article in a scientific journal)
The role of topoisomerase II in the excision of DNA loop domains during apoptosis (2002)
- Journal of Biological Chemistry
Solovyan VT, Bezvenyuk ZA, Salminen A, Austin CA, Courtney MJ
(A1 Refereed original research article in a scientific journal)