Michael Courtney
miccou@utu.fi +358 29 450 3739 +358 50 464 9827 Tykistökatu 6 Turku ORCID identifier: https://orcid.org/0000-0001-8693-3933 |
Areas of expertise
protein interactions; cell signalling; cell imaging; optical assays; single-cell methods; optogenetics; protein engineering; neuroscience; reporter design; AAV; assay development; drug discovery; compound screening; high-throughput methods; high-content analysis; lab automation
protein interactions; cell signalling; cell imaging; optical assays; single-cell methods; optogenetics; protein engineering; neuroscience; reporter design; AAV; assay development; drug discovery; compound screening; high-throughput methods; high-content analysis; lab automation
Publications 
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- Atomistic simulations reveal impacts of missense mutations on the structure and function of SynGAP1 (2024)
- Briefings in Bioinformatics
(A1 Refereed original research article in a scientific journal) - Synaptic proteome perturbations after maternal immune activation : Identification of embryonic and adult hippocampal changes (2024)
- Brain, Behavior, and Immunity
(A1 Refereed original research article in a scientific journal) - Disrupting the nNOS/NOS1AP interaction in the medial prefrontal cortex impairs social recognition and spatial working memory in mice (2023)
- European Neuropsychopharmacology
(A1 Refereed original research article in a scientific journal) - Hippocampal overexpression of NOS1AP promotes endophenotypes related to mental disorders (2021)
- EBioMedicine
(A1 Refereed original research article in a scientific journal) - Resonance energy transfer sensitises and monitors in situ switching of LOV2-based optogenetic actuators (2020)
- Nature Communications
(A1 Refereed original research article in a scientific journal) - RET-enhanced measurement of relaxation time constants of LOV2-based optogenetic actuators (Method article) (2020)
- Protocol exchange
(Other publication) - Establishing an effective dose for chronic intracerebroventricular administration of clozapine in mice (2019)
- Acta Neuropsychiatrica
(A1 Refereed original research article in a scientific journal) - Disruption of nNOS–NOS1AP protein–protein interactions suppresses neuropathic pain in mice (2018)
- PAIN
(A1 Refereed original research article in a scientific journal) - Spatial quantification of the synaptic activity phenotype across large populations of neurons with Markov random fields (2018)
- Bioinformatics
(A1 Refereed original research article in a scientific journal) - ZLc002, a putative small molecule inhibitor of nNOS interaction with NOS1AP, suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability (2018)
- Molecular Pain
(A1 Refereed original research article in a scientific journal) - A simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs (2017)
- Nature Communications
(A1 Refereed original research article in a scientific journal) - Cysteine 893 is a target of regulatory thiol modifications of GluA1 AMPA receptors (2017)
- PLoS ONE
(A1 Refereed original research article in a scientific journal) - Efficient Binding of the NOS1AP C-Terminus to the nNOS PDZ Pocket Requires the Concerted Action of the PDZ Ligand Motif, the Internal ExF Site and Structural Integrity of an Independent Element (2017)
- Frontiers in Molecular Neuroscience
(A1 Refereed original research article in a scientific journal) - ARHGAP12 Functions as a Developmental Brake on Excitatory Synapse Function (2016)
- Cell Reports
(A1 Refereed original research article in a scientific journal) - Inhibition of Excessive Oxidative Protein Folding Is Protective in MPP+ Toxicity-Induced Parkinson's Disease Models (2016)
- Antioxidants and Redox Signaling
(A1 Refereed original research article in a scientific journal) - Redox-Activated Signal Transduction Pathways Mediating Cellular Functions in Inflammation, Differentiation, Degeneration, Transformation, and Death (2016)
- Oxidative Medicine and Cellular Longevity
(B1 Non-refereed article in a scientific journal) - Unexpected Heterodivalent Recruitment of NOS1AP to nNOS Reveals Multiple Sites for Pharmacological Intervention in Neuronal Disease Models (2015)
- Journal of Neuroscience
(A1 Refereed original research article in a scientific journal) - Mechanisms of NOS1AP action on NMDA receptor-nNOS signaling (2014)
- Frontiers in Cellular Neuroscience
(A1 Refereed original research article in a scientific journal) - Miswiring the brain: Delta(9)-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway (2014)
- EMBO Journal
(A1 Refereed original research article in a scientific journal) - The nNOS-p38MAPK Pathway Is Mediated by NOS1AP during Neuronal Death (2013)
- Journal of Neuroscience
(A1 Refereed original research article in a scientific journal)
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