Kirsi Gröndahl-Yli-Hannuksela
kagron@utu.fi +358 29 450 4548 +358 50 347 3441 Kiinamyllynkatu 10 Turku ORCID identifier: https://orcid.org/0000-0003-1479-8925(external) |
bacteriology; medical bacteriology; beta haemolytic streptococci; clinical studies; epidemiological studies
2020 Adjunct professor in bacteriology (Uni. Turku), 2016 PhD in Paediatrics, Faculty of Medicine (Uni.Turku), 2007 MSc in biochemistry (Uni. Turku).
The main focus of my research is on beta haemolytic streptococci. Group A streptococci is one of the most common human pathogens. The disease spectrume is wide from mild tonsillitis to severe life-threathning conditions such as bacteremia. In addition to infections, Group A streptococci may colonize throat or skin asymtomatically. Carriage is significant factor for the spread of the bacteria.
Childbed fever of puerperal sepsis is a rare but severe disease condition that may develop after delivery. Group A streptococci is one of the common causatives of puerperal sepsis. The source of bacteria usually remains unknown.
Group B streptococci is another common human pathogen. It is transmitted from mother to newborn baby during the delivery. Bacteria may cause severe infection in the newbor as well as for the mother. In several countries, including Finland, Group B streptococci is screened from pregant women and treated before the delivery.
Academy of Finland has funded our research project on streptococci, pregancy and delivery. We have an ongoing clincal study in which we investigate the prevalence of asymptomatic carriage of beta haemolytic streptococci in pregnanct women and their partners. We investigate the identified streptococcal bacteria with several molecular techniques (such as whole genome sequencing, antimicrobial susceptility). In addition, we investigate the outcome of the pregnancy and delivery in relation to asymptomatic carriage of these bacteria.
Other research topics (in collab. with prof Jaana Vuopio) are epidemiology of group A streptococcal diseases (tonsillitis) and MRSA.
- The first human report of mobile colistin resistance gene, mcr-1, in Finland (2018)
- APMIS
(A1 Refereed original research article in a scientific journal) - Mannose-binding lectin gene polymorphism in relation to periodontal infection (2017)
- Journal of Periodontal Research
(A1 Refereed original research article in a scientific journal) - Rapid detection of functional gene polymorphisms of TLRs and IL-17 using high resolution melting analysis (2017)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - Pertussis specific cell-mediated immune responses ten years after acellular pertussis booster vaccination in young adults (2016)
- Vaccine
(A1 Refereed original research article in a scientific journal) - Polymorphism of IL-10 gene promoter region: association with T cell proliferative responses after acellular pertussis vaccination in adults (2016)
- Immunogenetics
(A1 Refereed original research article in a scientific journal) - Analysis of Bordetella pertussis clinical isolates circulating in European countries during the period 1998-2012 (2015)
- European Journal of Clinical Microbiology and Infectious Diseases
(A1 Refereed original research article in a scientific journal) - IL-10 Gene Polymorphisms Are Associated with Post-Bronchiolitis Lung Function Abnormalities at Six Years of Age (2015)
- PLoS ONE
(A1 Refereed original research article in a scientific journal) - Interleukin-10 gene promoter region polymorphisms are not associated with BCG osteitis in vaccinated infants (2015)
- International Journal of Tuberculosis and Lung Disease
(A1 Refereed original research article in a scientific journal) - Lyme borreliosis and deficient mannose-binding lectin pathway of complement (2015)
- Journal of Immunology
(A1 Refereed original research article in a scientific journal) - Pertussis: infection, vaccination and gene polymorphisms (2015) Gröndahl-Yli-Hannuksela Kirsi
(G5 Article dissertation ) - Seroprevalence studies of pertussis: what we learned in different immunized populations. (2015)
- Pathogens and Disease
(A2 Refereed review article in a scientific journal ) - Targeted activation of silent natural product biosynthesis pathways by reporter-guided mutant selection (2015)
- Metabolic Engineering
(A1 Refereed original research article in a scientific journal) - Whole-genome sequencing reveals the effect of vaccination on the evolution of Bordetella pertussis (2015)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - Lack of Association between Mannose Binding Lectin and Antibody Responses after Acellular Pertussis Vaccinations (2014)
- PLoS ONE
(A1 Refereed original research article in a scientific journal) - Increased risk of pertussis in adult patients with mannose-binding lectin deficiency (2013)
- APMIS
(A1 Refereed original research article in a scientific journal) - Variant MBL2 genotypes producing low mannose-binding lectin may increase risk of Bacillus Calmette-Guerin osteitis in vaccinated newborns (2013)
- Acta Paediatrica
(A1 Refereed original research article in a scientific journal) - Differences in avidity of IgG antibodies to pertussis toxin after acellular pertussis booster vaccination and natural infection (2012)
- Vaccine
(A1 Refereed original research article in a scientific journal) - Gene polymorphism in toll-like receptor 4: Effect on antibody production and persistence after acellular pertussis vaccination during adolescence (2012)
- Journal of Infectious Diseases
(A1 Refereed original research article in a scientific journal) - Mannose-Binding Lectin Gene Polymorphisms in Infants with Bronchiolitis and Post-Bronchiolitis Wheezing (2012)
- Allergology International
(A1 Refereed original research article in a scientific journal) - Differences in the genomic content of Bordetella pertussis isolates before and after introduction of pertussis vaccines in four European countries (2011)
- Infection, Genetics and Evolution
(A1 Refereed original research article in a scientific journal)