Kirsi Gröndahl-Yli-Hannuksela
kagron@utu.fi +358 29 450 4548 +358 50 347 3441 Kiinamyllynkatu 10 Turku ORCID identifier: https://orcid.org/0000-0003-1479-8925(external) |
bacteriology; medical bacteriology; beta haemolytic streptococci; clinical studies; epidemiological studies
2020 Adjunct professor in bacteriology (Uni. Turku), 2016 PhD in Paediatrics, Faculty of Medicine (Uni.Turku), 2007 MSc in biochemistry (Uni. Turku).
The main focus of my research is on beta haemolytic streptococci. Group A streptococci is one of the most common human pathogens. The disease spectrume is wide from mild tonsillitis to severe life-threathning conditions such as bacteremia. In addition to infections, Group A streptococci may colonize throat or skin asymtomatically. Carriage is significant factor for the spread of the bacteria.
Childbed fever of puerperal sepsis is a rare but severe disease condition that may develop after delivery. Group A streptococci is one of the common causatives of puerperal sepsis. The source of bacteria usually remains unknown.
Group B streptococci is another common human pathogen. It is transmitted from mother to newborn baby during the delivery. Bacteria may cause severe infection in the newbor as well as for the mother. In several countries, including Finland, Group B streptococci is screened from pregant women and treated before the delivery.
Academy of Finland has funded our research project on streptococci, pregancy and delivery. We have an ongoing clincal study in which we investigate the prevalence of asymptomatic carriage of beta haemolytic streptococci in pregnanct women and their partners. We investigate the identified streptococcal bacteria with several molecular techniques (such as whole genome sequencing, antimicrobial susceptility). In addition, we investigate the outcome of the pregnancy and delivery in relation to asymptomatic carriage of these bacteria.
Other research topics (in collab. with prof Jaana Vuopio) are epidemiology of group A streptococcal diseases (tonsillitis) and MRSA.
- Increasing trend of antimicrobial resistance among methicillin-resistant Staphylococcus aureus strains in Southwest Finland, 2007–2016: An analysis of shifting strain dynamics and emerging risk factors (2025)
- Journal of Global Antimicrobial Resistance
(A1 Refereed original research article in a scientific journal) - Low expression of the CCL5 gene and low serum concentrations of CCL5 in severe invasive group a streptococcal disease (2025)
- Infection
(A1 Refereed original research article in a scientific journal) - Single-cell transcriptome analysis of the early immune response in the lymph nodes of Borrelia burgdorferi-infected mice (2024)
- Microbes and Infection
(A1 Refereed original research article in a scientific journal) - Epidemiology and emm types among group A streptococcal pharyngitis in Finland: a prospective laboratory-based study (2023)
- European Journal of Clinical Microbiology and Infectious Diseases
(A1 Refereed original research article in a scientific journal) - Presence of Streptococcus pyogenes in the throat in invasive Group A Streptococcal disease: a prospective two-year study in two health districts, Finland (2023)
- Infectious Diseases
(A1 Refereed original research article in a scientific journal) - Detection of group A streptococcus in children with confirmed viral pharyngitis and antiviral host response (2022)
- European Journal of Pediatrics
(A1 Refereed original research article in a scientific journal) - Low rate of asymptomatic carriage and salivary immunoglobulin A response to Group A Streptococci in the healthy adult population in Finland (2022)
- Medical Microbiology and Immunology
(A1 Refereed original research article in a scientific journal) - Whole genome sequencing reveals new links between spa t172/CC59 methicillin-resistant Staphylococcus aureus cases in low-endemicity region of Southwest Finland, 2007‒2016 (2022)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - Genetic evolution of invasive emm28 Streptococcus pyogenes strains and significant association with puerperal infections in young women in Finland (2021)
- Clinical Microbiology and Infection
(A1 Refereed original research article in a scientific journal) - Changing epidemiology of methicillin-resistant Staphylococcus aureus in a low endemicity area- new challenges for MRSA control (2020)
- European Journal of Clinical Microbiology and Infectious Diseases
(A1 Refereed original research article in a scientific journal) - Group A streptococcal bacteremias in Southwest Finland 2007–2018: epidemiology and role of infectious diseases consultation in antibiotic treatment selection (2020)
- European Journal of Clinical Microbiology and Infectious Diseases
(A1 Refereed original research article in a scientific journal) - Performance of the Check-Direct ESBL Screen for BD MAXTM for detection of asymptomatic faecal carriage of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae (2020)
- Journal of Global Antimicrobial Resistance
(A1 Refereed original research article in a scientific journal) - Prevalence of pneumococcal nasopharyngeal colonization and serotypes circulating in Cameroonian children after the 13-valent pneumococcal conjugate vaccine introduction (2020)
- International Journal of Infectious Diseases
(A1 Refereed original research article in a scientific journal) - Reduced In Vitro Susceptibility of Streptococcus pyogenes to β-Lactam Antibiotics Associated with Mutations in the pbp2x Gene Is Geographically Widespread (2020)
- Journal of Clinical Microbiology
(A1 Refereed original research article in a scientific journal) - Antibiotic resistance of Escherichia coli from outpatient urinary tract infection in women in six European countries including Russia (2019)
- Journal of Global Antimicrobial Resistance
(A1 Refereed original research article in a scientific journal) - Integrated analysis of population genomics, transcriptomics and virulence provides novel insights into Streptococcus pyogenes pathogenesis (2019)
- Nature Genetics
(A1 Refereed original research article in a scientific journal) - Changing molecular epidemiology of methicillin-resistant Staphylococcus aureus in Southwest Finland, 2007 - 2016 (2018) Jenna Junnila, Tiina Hirvioja, Kaisu Rantakokko-Jalava, Kari Auranen, Esa Rintala, Laura Lindholm, Jaakko Silvola, Harri Marttila, Anu Harttio-Nohteri, Kirsi Gröndahl-Yli-Hannuksela, Jaana Vuopio
(Other publication) - ESBL:ää tuottavien suolistobakteerien oireeton kantajuus Etelä-Suomessa (2018)
- Lääkärilehti
(A1 Refereed original research article in a scientific journal) - Large variation in ESBL-producing Escherichia coli carriers in six European countries including Russia (2018)
- European Journal of Clinical Microbiology and Infectious Diseases
(A1 Refereed original research article in a scientific journal) - Performance of the Check-Direct ESBL Screen for BD MAX for detection of asymptomatic fecal carriage of ESBL producing E. coli and K. pneumonia (2018) Gröndahl-Yli-Hannuksela K, Lönnqvist E, Marttila H, Rintala E, Rantakokko-Jalava K, Vuopio J
(Other publication)