Thadee Grocholski

- Laboratory Engineer,
Analytiikkakeskus (Department of Chemistry)

thagro@utu.fi

Tykistökatu 6

Turku

Metabolic engineering of Streptomyces peucetius for biosynthesis of N,N-dimethylated anthracyclines (2024)
- Frontiers in Bioengineering and Biotechnology
Hulst Mandy B., Zhang Le, van der Heul Helga U., Du Chao, Elsayed Somayah S., Koroleva Arina, Grocholski Thadee, Wander Dennis P. A., Metsa-Ketela Mikko, Neefjes Jacques J. C., van Wezel Gilles P.
Evolution-inspired engineering of anthracycline methyltransferases (2023)
- PNAS nexus
Dinis Pedro, Tirkkonen Heli, Nji Wandi Benjamin N, Siitonen Vilja, Niemi Jarmo, Grocholski Thadée, Metsä-Ketelä Mikko
Anthracyclines: biosynthesis, engineering and clinical applications (2022)
- Natural Product Reports
Hulst Mandy B., Grocholski Thadee, Neefjes Jacques J.C., van Wezel Gilles P., Metsä-Ketelä Mikko
Chimeragenesis for Biocatalysis (2019) Advances in Enzyme Technology Pedro Dinis, Benjamin Nji Wandi, Thadée Grocholski, Mikko Metsä-Ketelä
Evolutionary Trajectories for the Functional Diversification of Anthracycline Methyltransferases (2019)
- ACS Chemical Biology
Grocholski T., Yamada K., Sinkkonen J., Tirkkonen H., Niemi J., Metsä-Ketelä M.
Monooxygenase Diversity and Oxygen Activation within Polyketide Antibiotic Biosynthesis (2016) Grocholski Thadee RP
Divergent evolution of an atypical S-adenosyl-L-methionine-dependent monooxygenase involved in anthracycline biosynthesis (2015)
- Proceedings of the National Academy of Sciences of the United States of America
Thadée Grocholski, Pedro Dinis, Laila Niiranen, Jarmo Niemi, Mikko Metsä-Ketelä
CBR antimicrobials alter coupling between the bridge helix and the β subunit in RNA polymerase (2014)
- Nature Communications
Malinen AM, Nandymazumdar M, Turtola M, Malmi H, Grocholski T, Artsimovitch I, Belogurov GA.
Characterization of the Two-Component Monooxygenase System AlnT/AlnH Reveals Early Timing of Quinone Formation in Alnumycin Biosynthesis (2012)
- Journal of Bacteriology
Grocholski T, Oja T, Humphrey L, Mäntsälä P, Niemi J, Metsä-Ketelä M
Crystal Structure of the Cofactor-Independent Monooxygenase SnoaB from Streptomyces nogalater: Implications for the Reaction Mechanism (2010)
- Biochemistry
Grocholski T, Koskiniemi H, Lindqvist Y, Mäntsälä P, Niemi J, Schneider G
Expression, purification and crystallization of the cofactor-independent monooxygenase SnoaB from the nogalamycin biosynthetic pathway (2009)
- Acta Crystallographica Section F: Structural Biology and Crystallization Communications
Koskiniemi H, Grocholski T, Schneider G, Niemi J