Lea Mikkola
PhD
Single-cell Immunogenomics lea.mikkola@utu.fi Työhuone: 5024 ORCID-tunniste: https://orcid.org/0000-0002-5315-7410 |
Genomiikka, kvantitatiivinen genetiikka
InFLAMES Research Flagship and Research Council of Finland.
I'm a Postdoctoral Researcher in the Single-cell Immunogenomics Research Group, Turku Bioscience, University of Turku, Finland (https://bioscience.fi/research/single-cell-genomics-immunology/profile/).
I'm the Principal Investigator of the project "Complex Molecular Etiology and Cellular Landscape of Hip Osteoarthritis (OASEQ)" (https://clinicaltrials.gov/ct2/show/NCT05278520).
My fields of expertise are computational genomics, quantitative genetics, and single-cell and spatial transcriptomics. I do research both in bioinformatics and wet lab.
I have been awarded a Postdoctoral Fellowship of the InFLAMES Research Flagship Center, University of Turku and Åbo Akademi in 2021, and a 3-year Postdoctoral Research Fellowship of Research Council of Finland (formerly Academy of Finland) in 2022.
In my primary ongoing research project I explore the molecular etiology and cellular landscape of hip joint osteoarthritis (OA), especially focusing on the role of immune responses in OA.
In my other main project I have applied single-cell and spatial omics approaches to elucidate the role of immune responses in the development of atherosclerosis, aiming to identify novel targets for therapeutic interventions (manuscript, see https://www.biorxiv.org/content/10.1101/2025.09.02.673686v1.full).
I'm collaborating in multiple other projects as a senior computational geneticist; designing, running and/or supervising the data analyses. These projects have been focusing on e.g. breast cancer, systemic lupus erythematosus, and stress/anxiety.
My main interests in teaching are bioinformatics and experimental design.
Teaching at the University of Turku:
-BIOL3050, "Bioinformatics for Biologists", first half of every spring semester since 2021.
-FYGE5430, "Next Generation Sequencing (NGS) and its Applications", second half of spring semester 2023.
Teaching at the University of Helsinki:
-Clinical Genetics (2020)
-Introduction to Research in Veterinary Medicine (2014, 2015, 2019, 2021, 2022, 2023)
-Comparative Anatomy and Physiology (2014, 2015)
International teaching experience:
-Experimental design for high-throughput technologies, Karolinska Institutet (2022, 2023).
-Bioinformatics Analysis and Visualisation of Medical Genomics Data, University of Tokyo and Karolinska Institutet, Tokyo, Japan, March 2023 and March 2025; RIKEN Research Institute and Karolinska Institutet in Yokohama Japan October 2023, and in Stockholm Sweden in September 2024.
I have completed 10 ECTS of Medical pedagogy studies at the University of Turku in 2024.
- COMPARISON OF TWO HIGH-RESOLUTION SPATIAL TRANSCRIPTOMICS TECHNOLOGIES TO STUDY SYNOVIAL IMMUNE INFILTRATION IN OSTEOARTHRITIS AND RHEUMATOID ARTHRITIS (2025)
- Osteoarthritis and Cartilage
(Abstrakti) - Identifying immune mediators of osteoarthritis pain (2025) Metso, Sara; Lönnberg, Tapio; Mikkola, Lea
(Konferenssiposteri) - Integrin β1 activity controls colony morphology during human pluripotent stem cell state transitions (2025)
- Stem Cell Reports
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - MicroRNA gene dynamics in immune cell subpopulations during aging and atherosclerosis disease development at single-cell resolution (2025)
- Genome Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Autismipiirteiden piilottamisen ei tule olla interventioiden tavoitteena (2024)
- Lääkärilehti
(D1 Artikkeli ammattilehdessä) - Dynamics of T cell and B cell receptor repertoires in response to obesity in a murine model of
atherosclerosis (2024)- European Journal of Immunology
(Abstrakti) - Eettiset haasteet autismin genomisessa tutkimuksessa (2024)
- Autismi
(E1 Yleistajuinen artikkeli lehdessä) - High-fidelity spatial transcriptomics reveals the distribution, interactions and relations of several inflammatory cell types in murine atherosclerotic plaques (2024)
- Atherosclerosis
(Abstrakti) - Obesity-induced changes in perivascular adipose tissue fibroblasts in a mouse model of atherosclerosis (2024)
- European Journal of Immunology
(Abstrakti) - Disease-associated cell states in atherosclerosis defined by spatial transcriptomics (2023)
- Atherosclerosis
(Abstrakti) - Ethical challenges in autism genomics: Recommendations for researchers (2023)
- European Journal of Medical Genetics
(A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä) - My postdoctoral research visit – super happy I did it! (2023)
- InFLAMES Flagship Blog
(E1 Yleistajuinen blogikirjoitus ) - An across-breed validation study of 46 genetic markers in canine hip dysplasia (2021)
- BMC Genomics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Genetic dissection of canine hip dysplasia phenotypes and osteoarthritis reveals three novel loci (2019)
- BMC Genomics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Novel protective and risk loci in hip dysplasia in German Shepherds (2019)
- PLoS Genetics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Genetic parameters for carcass weight, conformation and fat in five beef cattle breeds (2015)
- Animal
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )