Heli Harvala
MD, PhD, EUPHEM Alumni, FRCPath
Virology; Clinical Virology; Public Health Virology; Transfusion Virology
Heli Harvala was appointed as a Professor of Virology at the Institute of Biomedicine, University of Turku, Finland in September, 2024.
She graduated in Medicine, obtained a MSc in Organic Chemistry and a PhD in Virology at the University of Turku, Finland, in 2003. Subsequently she completed her Medical Virology training in Edinburgh and became a Fellow of the Royal College of Pathologists in 2015. During that time, she joined the European Public Health Microbiology fellowship programme at the Public Health Agency of Sweden for two years before returning back to the UK. Over the last ten years, she has combined her work as a Consultant Medical Virologist with clinical, transfusion and public health related virology research.
She is a co-founder of the European Non-Polio Enterovirus Network (ENPEN) which evaluates the importance of enterovirus infections and monitors for their emergence together with collaborators from over 30 European countries. During COVID-19 pandemic, she was involved with setting up SARS-CoV-2 testing of convalescent plasma donors in England, and the related international REMAP-CAP trial. She also has wide interests in molecular epidemiology and next generation sequencing, and is involved with investigations into how next generation sequencing could be used to enhance the effectiveness of microbiological donation screening.
She leads the Blood Safety research team within the NIHR funded Blood and Transplant Research Unit at the University of Oxford. This research focuses on transfusion transmitted viral infections aiming to improve our understanding of current risks and preparedness for emerging pathogens. She also recently led the work in identifying occult hepatitis B infections as a blood transfusion risk in England and has done pioneering work to investigate pre-exposure prophylaxis use among syphilis infected blood donors. While these activieis continue, she is currently establishing her research group at the University of Turku.
Prof Harvala is widely published in the field of medical, transfusion and public health virology (over 130 peer reviewed publications, h-index 48). She is an executive committee member of European Society for Clinical Virology and the programme committee member for the European Society for Clinical Microbiology and infectious Diseases. She was recently appointed to the WHO European Region Commission for the Certification of Poliomyelitis Eradication, and previously chaired the WHO R&D Blueprint group on Picornaviruses, the Microbiology Specialist Interest Group for the British Blood Transfusion Society, the Panel of Senior Virology Examiners for the RCPath and the Standing Advisory Committee for Transfusion Transmitted Infections.
She is currently involved in the undergraduate teaching of medical and biomedical students, being responsible for the virology part of that. She has previously been involved in the Undergraduate teaching at the University College of London, University of Edinburgh, the University of Oulu and at the University of Turku. She is also actively engaging with Postgraduate teaching by supervising both PhD and MSc students, and has undertaken PhD Supervisors training at the University of Oxford. Furthermore, she has extensive experience in Clinical Virology specialty training; she has been trained educational supervisor in Clinical Virology since 2016 and trained Royal College of Pathologist Examiner in Clinical Virology since 2017.
Her interest includes developing training further and as an example, she developed a new three-day module in Phylogenetics and Bioinformatics for European Centre for Disease Control (ECDC) Stockholm with the microbiological cases studies in 2016. Subsequently, she led the developing and delivering this for the ECDC summer schools in Stockholm, 2016 and 2017, and for the ECDC EPIET/EUPHEM fellows in Berlin, 2017 and 2018.
- The importance of enterovirus surveillance in a post-polio world (2022)
- Lancet Infectious Diseases
Fischer TK, Simmonds P, Harvala H
- Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials (2021) Axfors C, Janiaud P, Schmitt AM, Van't Hooft J, Smith ER, Haber NA, Abayomi A, Abduljalil M, Abdulrahman A, Acosta-Ampudia Y, Aguilar-Guisado M, Al-Beidh F, Alejandria MM, Alfonso RN, Ali M, AlQahtani M, AlZamrooni A, Anaya JM, Ang MAC, Aomar IF, Argumanis LE, Averyanov A, Baklaushev VP, Balionis O, Benfield T, Berry S, Birocco N, Bonifacio LB, Bowen AC, Bown A, Cabello-Gutierrez C, Camacho B, Camacho-Ortiz A, Campbell-Lee S, Cao DH, Cardesa A, Carnate JM, Castillo GJJ, Cavallo R, Chowdhury FR, Chowdhury FUH, Ciccone G, Cingolani A, Climacosa FMM, Compernolle V, Cortez CFN, Costa Neto A, D'Antico S, Daly J, Danielle F, Davis JS, De Rosa FG, Denholm JT, Denkinger CM, Desmecht D, Díaz-Coronado JC, Díaz Ponce-Medrano JA, Donneau AF, Dumagay TE, Dunachie S, Dungog CC, Erinoso O, Escasa IMS, Estcourt LJ, Evans A, Evasan ALM, Fareli CJ, Fernandez-Sanchez V, Galassi C, Gallo JE, Garcia PJ, Garcia PL, Garcia JA, Garigliany M, Garza-Gonzalez E, Gauiran DTV, Gaviria García PA, Giron-Gonzalez JA, Gómez-Almaguer D, Gordon AC, Gothot A, Grass Guaqueta JS, Green C, Grimaldi D, Hammond NE, Harvala H, Heralde FM, Herrick J, Higgins AM, Hills TE, Hines J, Holm K, Hoque A, Hoste E, Ignacio JM, Ivanov AV, Janssen M, Jennings JH, Jha V, King RAN, Kjeldsen-Kragh J, Klenerman P, Kotecha A, Krapp F, Labanca L, Laing E, Landin-Olsson M, Laterre PF, Lim LL, Lim J, Ljungquist O, Llaca-Díaz JM, López-Robles C, López-Cárdenas S, Lopez-Plaza I, Lucero JAC, Lundgren M, Macías J, Maganito SC, Malundo AFG, Manrique RD, Manzini PM, Marcos M, Marquez I, Martínez-Marcos FJ, Mata AM, McArthur CJ, McQuilten ZK, McVerry BJ, Menon DK, Meyfroidt G, Mirasol MAL, Misset B, Molton JS, Mondragon AV, Monsalve DM, Moradi Choghakabodi P, Morpeth SC, Mouncey PR, Moutschen M, Müller-Tidow C, Murphy E, Najdovski T, Nichol AD, Nielsen H, Novak RM, O'Sullivan MVN, Olalla J, Osibogun A, Osikomaiya B, Oyonarte S, Pardo-Oviedo JM, Patel MC, Paterson DL, Peña-Perez CA, Perez-Calatayud AA, Pérez-Alba E, Perkina A, Perry N, Pouladzadeh M, Poyato I, Price DJ, Quero AKH, Rahman MM, Rahman MS, Ramesh M, Ramírez-Santana C, Rasmussen M, Rees MA, Rego E, Roberts JA, Roberts DJ, Rodríguez Y, Rodríguez-Baño J, Rogers BA, Rojas M, Romero A, Rowan KM, Saccona F, Safdarian M, Santos MCM, Sasadeusz J, Scozzari G, Shankar-Hari M, Sharma G, Snelling T, Soto A, Tagayuna PY, Tang A, Tatem G, Teofili L, Tong SYC, Turgeon AF, Veloso JD, Venkatesh B, Ventura-Enriquez Y, Webb SA, Wiese L, Wikén C, Wood EM, Yusubalieva GM, Zacharowski K, Zarychanski R, Khanna N, Moher D, Goodman SN, Ioannidis JPA, Hemkens LG
- Comparability of six different immunoassays measuring SARS-CoV-2 antibodies with neutralizing antibody levels in convalescent plasma: From utility to prediction (2021) Lamikanra A, Nguyen D, Simmonds P, Williams S, Bentley EM, Rowe C, Otter AD, Brooks T, Gilmour K, Mai A, Dadhra J, Csatari M, Ziyenge S, Oliveira M, Ploeg R, Tsang P, Zambon M, Gopal R, Xiao JH, Townsend A, Roberts D, Harvala H
- Comparison of SARS-CoV-2 neutralizing antibody testing of convalescent plasma donations in the Netherlands and England: A pilot study (2021) Harvala H, Gopal R, Patel M, Zambon M, Roberts D, Lamikanra A, Ploeg R, Hoogerwerf M, Zaaijer H, Hogema B, Reusken C, van der Schoot E, Reimerink J
- Convalescent plasma therapy for the treatment of patients with COVID-19: Assessment of methods available for antibody detection and their correlation with neutralising antibody levels (2021) Harvala H, Robb ML, Watkins N, Ijaz S, Dicks S, Patel M, Supasa P, Wanwisa D, Liu C, Mongkolsapaya J, Bown A, Bailey D, Vipond R, Grayson N, Temperton N, Gupta S, Ploeg RJ, Bolton J, Fyfe A, Gopal R, Simmonds P, Screaton G, Thompson C, Brooks T, Zambon M, Miflin G, Roberts DJ
- Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial (2021)
- JAMA: Journal of the American Medical Association
Writing Committee for the REMAP-CAP Investigators, Estcourt LJ, Turgeon AF, McQuilten ZK, McVerry BJ, Al-Beidh F, Annane D, Arabi YM, Arnold DM, Beane A, Bégin P, van Bentum-Puijk W, Berry LR, Bhimani Z, Birchall JE, Bonten MJM, Bradbury CA, Brunkhorst FM, Buxton M, Callum JL, Chassé M, Cheng AC, Cove ME, Daly J, Derde L, Detry MA, De Jong M, Evans A, Fergusson DA, Fish M, Fitzgerald M, Foley C, Goossens H, Gordon AC, Gosbell IB, Green C, Haniffa R, Harvala H, Higgins AM, Hills TE, Hoad VC, Horvat C, Huang DT, Hudson CL, Ichihara N, Laing E, Lamikanra AA, Lamontagne F, Lawler PR, Linstrum K, Litton E, Lorenzi E, MacLennan S, Marshall J, McAuley DF, McDyer JF, McGlothlin A, McGuinness S, Miflin G, Montgomery S, Mouncey PR, Murthy S, Nichol A, Parke R, Parker JC, Priddee N, Purcell DFJ, Reyes LF, Richardson P, Robitaille N, Rowan KM, Rynne J, Saito H, Santos M, Saunders CT, Serpa Neto A, Seymour CW, Silversides JA, Tinmouth AA, Triulzi DJ, Turner AM, van de Veerdonk F, Walsh TS, Wood EM, Berry S, Lewis RJ, Menon DK, McArthur C, Zarychanski R, Angus DC, Webb SA, Roberts DJ, Shankar-Hari M
- European Non-Polio Enterovirus Network: Introduction of Hospital-Based Surveillance Network to Understand the True Disease Burden of Non-Polio Enterovirus and Parechovirus Infections in Europe (2021) Harvala H, Benschop KSM, Berginc N, Midgley S, Wolthers K, Simmonds P, Feeney S, Bailly JL, Mirand A, Fischer TK, On Behalf Of The Enpen Hospital-Based Surveillance Network
- Evaluation of SARS-CoV-2 antibody titers and potency for convalescent plasma donation: a brief commentary (2021) Wouters E, Steenhuis M, Schrezenmeier H, Tiberghien P, Harvala H, Feys HB, van der Schoot E
- Hepatitis B infections among blood donors in England between 2009 and 2018: Is an occult hepatitis B infection a risk for blood safety? (2021) Harvala H, Reynolds C, Gibney Z, Derrick J, Ijaz S, Davison KL, Brailsford S
- Mapping of serological testing and SARS-CoV-2 seroprevalence studies performed in 20 European countries, March-June 2020. (2021) Bubba L, Simmonds P, Fischer TK, Harvala H
- Molecular epidemiology and evolutionary trajectory of emerging echovirus 30, Europe (2021)
- Emerging Infectious Diseases
Benschop Kimberley S.M., Broberg Eeva, Hodcroft Emma, Schmitz Dennis, Albert Jan, Baicus Anda, Bailly Jean,Luc, Baldvinsdottir Gudrun, Berginc Natasa, Blomqvist Soile, Böttcher Sindy, Brytting Mia, Bujaki Erika, Cabrerizo Maria, Celma Cristina, Cinek Ondrej, Claas Eric C.J., Cremer Jeroen, Dean Jonathan, Dembinski Jennifer, Demchyshyna Iryna, Diedrich Sabine, Dudman Susanne, Dunning Jake, Dyrdak Robert, Emmanouil Mary, Farkas Agnes, De Gascun Cillian, Fournier Guillme, Georgieva Irina, Gonzalez Sanz Ruben, van Hooydonk Elving Jolanda, Jääskeläinen Anne, Jancskaite Ruta, Keeren Kathrin, Fischer Thea, Krokstad Sidsel, Nikolaeva-Glomb Lubomira, Novakova Ludmila, Midgley Sofie, Mirand Drey, Molenkamp Richard, Morley Ursula, Mossong Joël, Muralyte Svajune, Murk Jean,Luc, Nguyen Trung, Nordbø Svein, Österback Riikka, Pas Suzan, Pellegrinelli Lra, Pogka Vassiliki, Prochazka Birgit, Rainetova Petra, Van Ranst Marc, Roorda Lieuwe, Schuffenecker Isabelle, Schuurman Rob, Stoyanova Asya, Templeton Kate, Verweij Jaco, Voulgari,Kokota Androniki, Vuorinen Tytti, Wollants Elke, Wolthers Katja, Zakikhany Katherina, Neher Richard, Harvala Heli, Simmonds Peter
- Recommendations for the introduction of metagenomic high-throughput sequencing in clinical virology, part I: Wet lab procedure (2021)
- Journal of Clinical Virology
López-Labrador F. Xavier, Brown Julianne R., Fischer Nicole, Harvala Heli, Van Boheemen Sander, Cinek Ondrej, Sayiner Arzu, Madsen Tina Vasehus, Auvinen Eeva, Kufner Verena, Huber Michael, Rodriguez Christophe, Jonges Marcel, Hönemann Mario, Susi Petri, Sousa Hugo, Klapper Paul E., Pérez-Cataluňa Alba, Hernandez Marta, Molenkamp Richard, van der Hoek Lia, Schuurman Rob, Couto Natacha, Leuzinger Karoline, Simmonds Peter, Beer Martin, Höper Dirk, Kamminga Sergio, Feltkamp Mariet C.W., Rodríguez-Díaz Jesús, Keyaerts Els, Nielsen Xiaohui Chen, Puchhammer-Stöckl Elisabeth, Kroes Aloys C.M., Buesa Javier, Breuer Judy, Claas Eric C.J., de Vries Jutte J.C.; on behalf of the ESCV Network on Next-Generation Sequencing
- Re-emergence of enterovirus D68 in Europe after easing the COVID-19 lockdown, September 2021 (2021) Benschop Kimberley SM, Albert Jan, Anton Andres, Andrés Cristina, Aranzamendi Maitane, Armannsdóttir Brynja, Bailly Jean-Luc, Baldanti Fausto, Baldvinsdóttir Guðrún Erna , Beard Stuart, Berginc Natasa, Böttcher Sindy, Blomqvist Soile, Bubba Laura, Calvo Cristina, Cabrerizo Maria, Cavallero Annalisa, Celma Cristina, Ceriotti Ferruccio, Costa Inês, Cottrell Simon, del Cuerpo Margarita, Dean Jonathan, Dembinski Jennifer L, Diedrich Sabine, Diez-Domingo Javier, Dorenberg DagnyHaug, Duizer Erwin, Dyrdak Robert, Fanti Diana, Farkas Agnes, Feeney Susan, Flipse Jacky, De Gascun Cillian, Galli Cristina, Georgieva Irina, Gifford Laura, Guiomar Raquel, Hönemann Mario, Ikonen Niina, Jeannoël Marion, Josset Laurence, Keeren Kathrin, López-Labrador F Xavier, Maier Melanie, McKenna James, Meijer Adam, Mengual-Chuliá Beatriz, Midgley Sofie E, Mirand Audrey, Montes Milagrosa, Moore Catherine, Morley Ursula, Murk Jean-Luc, Nikolaeva-Glomb Lubomira, Numanovic Sanela, Oggioni Massimo, Palminha Paula, Pariani Elena, Pellegrinelli Laura, Piralla Antonio, Pietsch Corinna, Piñeiro Luis, Rabella Núria, Rainetova Petra, Renteria Sara Colonia Uceda, Romero María P, Reynders Marijke, Roorda Lieuwe, Savolainen-Kopra Carita, Schuffenecker Isabelle, Soynova Aysa, Caroline MA Swanink, Ursic Tina, Verweij Jaco J, Vila Jorgina, Vuorinen Tytti, Simmonds Peter, Fischer Thea K, Harvala Heli
- SARS-CoV-2 neutralising antibody testing in Europe: towards harmonisation of neutralising antibody titres for better use of convalescent plasma and comparability of trial data (2021) Nguyen D, Simmonds P, Steenhuis M, Wouters E, Desmecht D, Garigliany M, Romano M, Barbezange C, Maes P, Van Holm B, Mendoza J, Oyonarte S, Fomsgaard A, Lassaunière R, Zusinaite E, Resman Rus K, Avšič-Županc T, Reimerink JH, Brouwer F, Hoogerwerf M, Reusken CB, Grodeland G, Le Cam S, Gallian P, Amroun A, Brisbarre N, Martinaud C, Leparc Goffart I, Schrezenmeier H, Feys HB, van der Schoot CE, Harvala H
- Seroprevalence and Virologic Surveillance of Enterovirus 71 and Coxsackievirus A6, United Kingdom, 2006-2017. (2021)
- Emerging Infectious Diseases
Kamau E, Nguyen D, Celma C, Blomqvist S, Horby P, Simmonds P, Harvala H
- Understanding the outcomes of COVID-19 - does the current model of an acute respiratory infection really fit? (2021)
- Journal of General Virology
Simmonds P, Williams S, Harvala H
- Virological Characterization of Critically Ill Patients With COVID-19 in the United Kingdom: Interactions of Viral Load, Antibody Status, and B1.1.7 Infection (2021)
- Journal of Infectious Diseases
Ratcliff J, Nguyen D, Fish M, Rynne J, Jennings A, Williams S, Al-Beidh F, Bonsall D, Evans A, Golubchik T, Gordon AC, Lamikanra A, Tsang P, Ciccone NA, Leuscher U, Slack W, Laing E, Mouncey PR, Ziyenge S, Oliveira M, Ploeg R, Rowan KM, Shankar-Hari M, Roberts DJ, Menon DK, Estcourt L, Simmonds P, Harvala H, REMAP-CAP Immunoglobulin Domain UK Investigators
- A European multicentre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts (2020)
- Journal of Medical Virology
Hayes A, Nguyen D, Andersson M, Anton A, Bailly JL, Beard S, Benschop KSM, Berginc N, Blomqvist S, Cunningham E, Davis D, Dembinski JL, Diedrich S, Dudman SG, Dyrdak R, Eltringham GJA, Gonzales-Goggia S, Gunson R, Howson-Wells HC, Jaaskelainen AJ, Lopez-Labrador FX, Maier M, Majumdar M, Midgley S, Mirand A, Morley U, Nordbo SA, Oikarinen S, Osman H, Papa A, Pellegrinelli L, Piralla A, Rabella N, Richter J, Smith M, Strand AS, Templeton K, Vipond B, Vuorinen T, Williams C, Wollants E, Zakikhany K, Fischer TK, Harvala H, Simmonds P
- Circulation of non-polio enteroviruses in 24 EU and EEA countries between 2015 and 2017: a retrospective surveillance study (2020)
- Lancet Infectious Diseases
Bubba L, Broberg EK, Jasir A, Simmonds P, Harvala H, Enterovirus study collaborators
- Convalescent plasma for COVID-19: male gender, older age and hospitalisation associated with high neutralising antibody levels, England, 22 April to 12 May 2020. (2020) Mehew J, Johnson R, Roberts D, Harvala H