Gautier Follain
 

Turku Collegium for Science, Medicine and Technology (TCSMT)

gautier.follain@utu.fi




ORCID identifier: https://orcid.org/0000-0003-0495-9529

Areas of expertise
Cell Biology, Cancer biology, Biophysics.


Biography

I did a PhD in life science in the lab. of Dr. Jacky Goetz (Strasbourg). I studied the role of blood flow forces on arrest, adhesion and extravasation of circulating breast/mammary cells, using multiple imaging modalities, mostly applied to microfluidics and zebrafish embryos. I described endothelial remodeling around arrested tumor cells as an extravasation mechanism of cancer cells (Follain et al. Dev cell 2018). Our works demonstrated that not only size exclusion but also shear forces are biophysic parameters driving the metastatic spreading (Follain et al. NRC 2020).
I moved to Turku in 2020 as a shared postdoc between the Cell Adhesion and Cancer lab of Prof. J. Ivaska and the lab of Dr. G. Jacquemet focusing on cellular protrusion and Cell Migration. I used similar models to study the metastatic cascade of Pancreatic Ductal AdenoCarcinoma.



Research

Main focus : Studying the metastatic spreading of Pancreatic Ductal AdenoCarcinoma.



Publications
  
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  • Cell viscosity influences haematogenous dissemination and metastatic extravasation of tumour cells  (2026)  
    • Nature Materials
     Gensbittel, Valentin; Yesilata, Zeynep; Bochler, Louis; Follain, Gautier; Nemoz-Billet, Laurie; Lefebvre, Olivier; Uhlmann, Klemens; Larnicol, Annabel; Ammirati, Giulia E. M.; Harlepp, Sébastien; Goswami, Ruchi; Girardo, Salvatore; Paulen, Laetitia; Hyenne, Vincent; Mittelheisser, Vincent; Stemmelen, Tristan; Molitor, Anne; Carapito, Raphael; Belthier, Guillaume; Pannequin, Julie; Kräter, Martin; Müller, Daniel J.; Balzani, Daniel; Guck, Jochen; Osmani, Naël; Goetz, Jacky G.
    (    A1 Refereed original research article in a scientific journal)


  • Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers  (2026)  
    • EMBO Journal
     Follain, Gautier; Ghimire, Sujan; Pylvänäinen, Joanna W; Vaitkevičiūtė, Monika; Hidalgo-Cenalmor, Iván; Wurzinger, Diana; Guzmán, Camilo; Conway, James R W; Dibus, Michal; Härkönen, Jouni; Oikari, Sanna; Rilla, Kirsi; Salmi, Marko; Ivaska, Johanna; Jacquemet, Guillaume
    (    A1 Refereed original research article in a scientific journal)


  • Restoring the tumour mechanophenotype of vocal fold cancer reverts its malignant properties  (2026)  
    • Nature Materials
     Kaivola, Jasmin; Punovuori, Karolina; Chastney, Megan R.; Abdo, Hind; Follain, Gautier; Mathieu, Mathilde; Joshi, Omkar; Miroshnikova, Yekaterina A.; Krautgasser, Fabian; Di Franco, Jasmin; Conway, James R. W.; Held, Sofia; Bertillot, Fabien; Hagström, Jaana; Mäkitie, Antti; Irjala, Heikki; Ventelä, Sami; Hamidi, Hellyeh; Scita, Giorgio; Cerbino, Roberto; Wickström, Sara A.; Ivaska, Johanna
    (    A1 Refereed original research article in a scientific journal)


  • Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells  (2025)  
    • Nature Cell BiologyNature Methods
     Conway, James R. W.; Joshi, Omkar; Kaivola, Jasmin; Follain, Gautier; Gounis, Michalis; Kühl, David; Ivaska, Johanna
    (    A1 Refereed original research article in a scientific journal)


  • Efficiently accelerated bioimage analysis with NanoPyx, a Liquid Engine-powered Python framework  (2025)  
       Saraiva, Bruno M.; Cunha, Inês; Brito, António D.; Follain, Gautier; Portela, Raquel; Haase, Robert; Pereira, Pedro M.; Jacquemet, Guillaume; Henriques, Ricardo
      (      A1 Refereed original research article in a scientific journal)


    • Time, the final frontier  (2025)  
      • Molecular Oncology
       Follain, Gautier; Dibus, Michal; Joshi, Omkar; Jacquemet, Guillaume
      (      A2 Refereed review article in a scientific journal )


    • Multiparameter imaging reveals clinically relevant cancer cell-stroma interaction dynamics in head and neck cancer  (2024)  
      • CellJournal of Cell Biology
       Punovuori, Karolina; Bertillot, Fabien; Miroshnikova, Yekaterina A.; Binner, Mirjam I.; Myllymäki, Satu-Marja; Follain, Gautier; Kruse, Kai; Routila, Johannes; Huusko, Teemu; Pellinen, Teijo; Hagström, Jaana; Kedei, Noemi; Ventelä, Sami; Mäkitie, Antti; Ivaska, Johanna; Wickström, Sara A.
      (      A1 Refereed original research article in a scientific journal)


    • Platelets favor the outgrowth of established metastasesDefined extracellular matrix compositions support stiffness-insensitive cell spreading and adhesion signaling2024
      • Nature CommunicationsProceedings of the National Academy of Sciences of the United States of America
       Garcia-Leon, Maria J.; Liboni, Cristina; Mittelheisser, Vincent; Bochler, Louis; Follain, Gautier; Mouriaux, Clarisse; Busnelli, Ignacio; Larnicol, Annabel; Colin, Florent; Peralta, Marina; Osmani, Naël; Gensbittel, Valentin; Bourdon, Catherine; Samaniego, Rafael; Pichot, Angélique; Paul, Nicodème; Molitor, Anne; Carapito, Raphaël; Jandrot-Perrus, Martine; Lefebvre, Olivier; Mangin, Pierre H.; Goetz, Jacky G.
      (      A1 Refereed original research article in a scientific journal)


    • TLNRD1 is a CCM complex component and regulates endothelial barrier integrity  (2024)  
         Ball, Neil J.; Ghimire, Sujan; Follain, Gautier; Pajari, Ada O.; Wurzinger, Diana; Vaitkevičiūtė, Monika; Cowell, Alana R.; Berki, Bence; Ivaska, Johanna; Paatero, Ilkka; Goult, Benjamin T.; Jacquemet, Guillaume
        (        A1 Refereed original research article in a scientific journal)


      •   (2023)  
           Conway James R.W., Isomursu Aleksi, Follain Gautier, Härmä Ville, Jou-Ollé Eva, Pasquier Nicolas, Välimäki Eetu P.O., Rantala Juha K., Ivaska Johanna
          (          A1 Refereed original research article in a scientific journal)



        Last updated on 23/08/2025 02:18:20 AM