Jenna Rannikko - UTU Research Portal

Jenna Rannikko

- Doctoral Researcher,
Institute of Biomedicine (Faculty of Medicine)
- Doctoral Researcher,
MediCity (Faculty of Medicine)

jenna.h.rannikko@utu.fi

Publications

Clever-1 inhibition in human cancer: consequences and control of bexmarilimab-induced macrophage activation (2026) Rannikko, Jenna
(G5 Article dissertation )
CLEVER-1 targeting antibody, bexmarilimab, supports HLA-DR expression and alters ex vivo responsiveness to azacitidine and venetoclax in myeloid malignancies (2025)
- Scientific Reports
Aakko, Sofia; Ylitalo, Arno; Kuusanmäki, Heikki; Rannikko, Jenna H.; Björkman, Mari; Mandelin, Jami; Heckman, Caroline A.; Kontro, Mika; Hollmén, Maija
(A1 Refereed original research article in a scientific journal)
Macrophage sensitivity to bexmarilimab-induced reprogramming is shaped by the tumor microenvironment (2025)
- Journal for Immunotherapy of Cancer
Rannikko, Jenna H.; Turpin, Rita; Boström, Pia; Virtakoivu, Reetta; Harth, Chantal; Takeda, Akira; Tamminen, Anselm; Koskivuo, Ilkka; Hollmén, Maija
(A1 Refereed original research article in a scientific journal)
Patient-derived tumor explant models of tumor immune microenvironment reveal distinct and reproducible immunotherapy responses (2025)
- OncoImmunology
Mutka, Minna; Kovanen, Panu E.; Niinikoski, Laura; Meretoja, Tuomo; Mattson, Johanna; Järvinen, Petrus; Lahdensuo, Kanerva; Järvinen, Riikka; Tornberg, Sara; Mirtti, Tuomas; Boström, Pia; Koskivuo, Ilkka; Thotakura, Anil; Pouwels, Jeroen; Hollmen, Maija; Mustjoki, Satu; Klefstroem, Juha
(A1 Refereed original research article in a scientific journal)
Secreted Clever-1 modulates T cell responses and impacts cancer immunotherapy efficacy (2025)
- Theranostics
Prince, Stuart; Viitala, Miro; Sjoroos, Riikka; Bendes, Abris a.; Rannikko, Jenna H.; Patten, Daniel A.; di Benedetto, Ilaria; Turpin, Rita; Ylitalo, Arno; Tyni, Laura; Figueiredo, Carlos R.; Bostrom, Pia; Koskivuo, Ilkka; Salminen, Tiina A.; Shetty, Shishir; Hollmen, Maija
(A1 Refereed original research article in a scientific journal)
Bexmarilimab Activates Human Tumor-Associated Macrophages to Support Adaptive Immune Responses in Interferon-Poor Immune Microenvironments (2024)
- Cancer Immunology Research
Rannikko, Jenna H.; Bono, Petri; Hynninen, Johanna; Hollmén, Maija
(A1 Refereed original research article in a scientific journal)
Clinical landscape of macrophage-reprogramming cancer immunotherapies (2024)
- British Journal of Cancer
Rannikko, Jenna H.; Hollmén, Maija

(A2 Refereed review article in a scientific journal )
Respiratory complex I regulates dendritic cell maturation in explant model of human tumor immune microenvironment (2024)
- Journal for Immunotherapy of Cancer
Turpin, Rita; Liu, Ruixian; Munne, Pauliina M.; Peura, Aino; Rannikko, Jenna H.; Philips, Gino; Boeckx, Bram; Salmelin, Natasha; Hurskainen, Elina; Suleymanova, Ilida; Aung, July; Vuorinen, Elisa M.; Lehtinen, Laura; Mutka, Minna; Kovanen, Panu E.; Niinikoski, Laura; Meretoja, Tuomo J.; Mattson, Johanna; Mustjoki, Satu; Saavalainen, Päivi; Goga, Andrei; Lambrechts, Diether; Pouwels, Jeroen; Hollmén, Maija; Klefström, Juha
(A1 Refereed original research article in a scientific journal)
Bexmarilimab-induced macrophage activation leads to treatment benefit in solid tumors : The phase I/II first-in-human MATINS trial (2023)
- Cell Reports Medicine
Rannikko Jenna H., Verlingue Loic, de Miguel Maria, Pasanen Annika, Robbrecht Debbie, Skytta Tanja, Iivanainen Sanna, Shetty Shishir, Ma Yuk Ting, Graham Donna M., Arora Sukeshi Patel, Jaakkola Panu, Yap Christina, Xiang Yujuan, Mandelin Jami, Karvonen Matti K., Jalkanen Juho, Karaman Sinem, Koivunen Jussi P., Minchom Anna, Hollmén Maija, Bono Petri
(A1 Refereed original research article in a scientific journal)
The effect of acute exercise on circulating immune cells in newly diagnosed breast cancer patients (2023)
- Scientific Reports
Koivula Tiia, Lempiäinen Salla, Rinne Petteri, Rannikko Jenna H., Hollmén Maija, Sundberg Carl Johan, Rundqvist Helene, Minn Heikki, Heinonen Ilkka
(A1 Refereed original research article in a scientific journal)
A distinct M2 macrophage infiltrate and transcriptomic profile decisively influence adipocyte differentiation in lipedema (2022)
- Frontiers in immunology
Wolf Stefan, Rannikko Jenna H., Virtakoivu Reetta, Cinelli Paolo, Felmerer Gunther, Burger Anna, Giovanoli Pietro, Detmar Michael, Lindenblatt Nicole, Hollmén Maija, Gousopoulos Epameinondas
(A1 Refereed original research article in a scientific journal)
Nonclinical Characterization of Bexmarilimab, a Clever-1-Targeting Antibody for Supporting Immune Defense Against Cancers (2022)
- Molecular Cancer Therapeutics
Hollmén Maija, Maksimow Mikael, Rannikko Jenna H, Karvonen Matti K, Vainio Marita, Jalkanen Sirpa, Jalkanen Markku, Mandelin Jami
(A1 Refereed original research article in a scientific journal)
Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors: Results from a Phase I/II Clinical Trial (2021)
- Clinical Cancer Research
Virtakoivu Reetta, Rannikko Jenna H, Viitala Miro, Vaura Felix, Takeda Akira, Lönnberg Tapio, Koivunen Jussi, Jaakkola Panu, Pasanen Annika, Shetty Shishir, de Jonge Maja JA, Robbrecht Debbie, Ma Yuk Ting, Skyttä Tanja, Minchom Anna, Jalkanen Sirpa, Karvonen Matti K, Mandelin Jami, Bono Petri, Hollmén Maija
(A1 Refereed original research article in a scientific journal)