Kati Hanhineva
kati.hanhineva@utu.fi +358 29 450 4044 +358 50 472 1814 ORCID identifier: https://orcid.org/0000-0001-6834-7375 |
phytochemicals, food chemistry, food development, fermentation, metabolomics, microbiota, nutrition
I am professor in food development with special focus on Nordic
foods and health effects at the University of Turku, Department of
Biochemistry, Food Chemistry and Food Development unit since beginning of 2020.
Part of my research group is situated at the School of Public Health and Clinical
Nutrition at the University of Eastern Finland. Since fall 2019 I am also affiliated
as visiting scientist (Marie Curie MoRE2020 Fellow) at the Division of Food and
Nutrition Science, Department of Biology and Biological Engineering at the Chalmers
University of Technology, Gothenburg, Sweden. I have the docentship in nutrition
and food metabolomics at the Faculty of Health Sciences, University of Eastern
Finland.
I completed PhD in biotechnology at the University of Kuopio 2008.
During years 2008-2014 I conducted post-doctoral research at the Department of
Public Health and Clinical Nutrition, at the University of Eastern Finland with
several research visits to the Weizmann Institute of Science in Israel. Since
2014 I have been the principal investigator in food and nutritional
metabolomics research group and led and participated in several national and
EU-funded research projects including Academy Researcher fellowship 2014-2019.
My main research focus is within the biochemistry of foods,
especially phytochemical compounds and the effect of food processing such as
fermentation on their composition. Likewise, molecular level understanding of
the role of nutrition in maintaining good health, and food-microbiota
interaction are within the core of my research. The key analytical technology
at the different stages of research is the mass-spectrometry based metabolic
profiling that I have developed and utilized for various food and nutrition
related applications, in particular within projects related to the beneficial
health effect of whole grain rich diets.
- Heart specific PGC-1α deletion identifies metabolome of cardiac restricted metabolic heart failure (2019) Kärkkäinen O, Tuomainen T, Mutikainen M, Lehtonen M, Ruas JL, Hanhineva K, Tavi P
(A1 Refereed original research article in a scientific journal) - Joint Analysis of Metabolite Markers of Fish Intake and Persistent Organic Pollutants in Relation to Type 2 Diabetes Risk in Swedish Adults (2019)
- Journal of Nutrition
(A1 Refereed original research article in a scientific journal) - Liver DNA methylation of FADS2 associates with FADS2 genotype (2019)
- Clinical Epigenetics
(A1 Refereed original research article in a scientific journal) - Mastication-induced release of compounds from rye and wheat breads to saliva (2019)
- Food Chemistry
(A1 Refereed original research article in a scientific journal) - Metabolic Profiling of High Egg Consumption and the Associated Lower Risk of Type 2 Diabetes in Middle-Aged Finnish Men (2019)
- Molecular Nutrition and Food Research
(A1 Refereed original research article in a scientific journal) - Metabolic signature of extracellular vesicles depends on the cell culture conditions (2019)
- Journal of Extracellular Vesicles
(A1 Refereed original research article in a scientific journal) - Nutrimetabolomics: An Integrative Action for Metabolomic Analyses in Human Nutritional Studies (2019)
- Molecular Nutrition and Food Research
(A2 Refereed review article in a scientific journal ) - Quantitative assessment of betainized compounds and associations with dietary and metabolic biomarkers in the randomized study of the healthy Nordic diet (SYSDIET). (2019)
- American Journal of Clinical Nutrition
(A1 Refereed original research article in a scientific journal) - Random forest-based imputation outperforms other methods for imputing LC-MS metabolomics data: a comparative study (2019)
- BMC Bioinformatics
(A1 Refereed original research article in a scientific journal) - Total liver phosphatidylcholine content associates with non-alcoholic steatohepatitis and glycine N-methyltransferase expression (2019)
- Liver International
(A1 Refereed original research article in a scientific journal) - Alcohol and substance use are associated with altered metabolome in the first trimester serum samples of pregnant mothers (2018)
- European Journal of Obstetrics and Gynecology and Reproductive Biology
(A1 Refereed original research article in a scientific journal) - A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants (2018)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals (2018)
- Nutrition and Diabetes
(A1 Refereed original research article in a scientific journal) - Diets rich in whole grains increase betainized compounds associated with glucose metabolism (2018)
- American Journal of Clinical Nutrition
(A1 Refereed original research article in a scientific journal) - Fearful dogs have increased plasma glutamine and γ-glutamyl glutamine (2018)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - High-Fat Diet, Betaine, and Polydextrose Induce Changes in Adipose Tissue Inflammation and Metabolism in C57BL/6J Mice (2018)
- Molecular Nutrition and Food Research
(A1 Refereed original research article in a scientific journal) - HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage (2018)
- Brain, Behavior, and Immunity
(A1 Refereed original research article in a scientific journal) - Interlaboratory Coverage Test on Plant Food Bioactive Compounds and their Metabolites by Mass Spectrometry-Based Untargeted Metabolomics (2018)
- Metabolites
(A1 Refereed original research article in a scientific journal) - Metabolic profiling of sourdough fermented wheat and rye bread (2018)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - Novel Biomarker Candidates for Febrile Neutropenia in Hematological Patients Using Nontargeted Metabolomics (2018)
- Disease Markers
(A1 Refereed original research article in a scientific journal)