I have doctoral training in Immunology and Microbiology, with emphasis on cancer immunology and drug development. I have post-doctoral training in clinical pathology, with a substantial background in biomarker discovery for cancer prognostication and rational development of new immunotherapies. 

In Europe, the highest incidence rates of melanoma occur in Nordic countries and Switzerland, where the inhabitants are predominantly light-skinned. In Finland, melanoma is the 5th most prevalent form of cancer with 1.669 new cases per year (Globocan 2018, WHO).

Immunotherapies that target immune checkpoint regulatory (ICR) molecules, such as the cytotoxic T lymphocyte antigen 4 (CTLA-4) and the programmed cell death 1 (PD-1), also called immune checkpoint blockers (ICB) have become standard treatments for metastatic melanoma and other cancer types, achieving impressive clinical improvements.

However, only a subset of cancer patients shows clinical benefits with these treatments. In metastatic melanoma, 20% of patients with distant metastasis achieve 5-year survival following immunotherapies using ICB, and the vast majority are refractory or will relapse the initial treatments by developing resistance mechanisms.

Therefore, understanding the fundamental mechanisms that underlie ICB resistance in metastatic melanoma, and developing strategies that mitigate these mechanisms are critical steps to unleash the full power of ICBs. 

By applying state-of-the-art technologies, including Mass Cytometry and Digital Spatial Profiling (NanoString), we are uncovering novel pathways associated with ICB resistance, mostly involved in the mechanisms of T lymphocyte suppression, which will provide new directions towards combinatory therapies for metastatic cutaneous and uveal melanoma. 

These strategies are based on the combination of new drugs developed in my group, the Melanoma Immune Oncology Research Group (MIORG), or the validation of already approved molecules in clinical trials for the management of other diseases. These treatments are selected as potential candidates to modulate or reverse the immune profile of metastatic melanoma associated with innate and acquired resistance to immunotherapies. 

My research is aligned with sustainable development by engaging a participatory society for citizens. We are committed to promoting equal opportunities to enable all people to have access to the most recent updates related to the field of metastatic melanoma prognostication and therapy in Finland and worldwide.

ACTIVITY IN PLANNING AND DEVELOPING TEACHING

2010 – 2018       Teaching at the Department of Microbiology, Immunology and Parasitology (DMIP) from the Federal University of São Paulo. Courses in Tumor immunology.

2010 – 2018       Teaching at the Experimental Oncology Unit, DMIP and Ibirapuera University. Courses in Tumor Immunology and Cancer Pharmacology

2015 – 2016       Teaching at the Sao Paulo Research and Education Institute. Courses: Basic Immunology, Microbiology, Cell Biology, Virology and Epidemiology.

2018 – 2019       Teaching at the North West Cancer Research Center and Institute of Translational Medicine, from the University of Liverpool. Seminars in tumor immunology, immune profiling and molecular pathology.

2020 – Present       Teaching at the Faculty of Medicine, University of Turku, Finland. Courses in Molecular Medicine.

2020 – Present       Teaching at the University of Turku, Finland. Courses in Molecular Medicine. Courses in Basic and Advanced Immunology.