Heli Tirkkonen - UTU Research Portal

Heli Tirkkonen

- Doctoral Researcher,
Department of Life Technologies (Faculty of Technology)
- Doctoral Researcher,
Biochemistry (Department of Life Technologies)

heli.m.tirkkonen@utu.fi

ORCID identifier: https://orcid.org/0000-0002-9913-226X

Areas of expertise

streptomyces; natural products chemistry; microbial interactions

Research

I study microbial interactions between Streptomyces and other microbes. Streptomyces utilize enzymes and natural products in their warfare against other microbes. By studying these interactions, we can uncover new antimicrobial compounds.

Publications

Metabolic engineering of doxorubicin biosynthesis through P450-redox partner optimization and structural analysis of DoxA (2026)
- Nature Communications
Koroleva, Arina; Artukka, Erika; Yamada, Keith; Newmister, Sean A.; Harte, Ralph J.; Boesger, Hannah; Londen, Mikael; Sanders, Jacob N.; Tirkkonen, Heli; Kannisto, Matti; Kuin, Rosan C. M.; Hulst, Mandy; Wang, Rongbin; Leskinen, Ester; Barillec, Morgane; Niemi, Jarmo; van Wezel, Gilles P.; Neefjes, Jacques; Nybo, S. Eric; Houk, Kendall N.; Sherman, David H.; Kim, Robbert Q.; Metsä-Ketelä, Mikko
(A1 Refereed original research article in a scientific journal)
Engineering BioBricks for Deoxysugar Biosynthesis and Generation of New Tetracenomycins (2023)
- ACS Omega
Tirkkonen Heli, Brown Katelyn V, Niemczura Magdalena, Faudemer Zélie, Brown Cortney, Ponomareva Larissa V , Helmy Yorsta A, Thorson Jon S, Nybo S Eric, Metsä-Ketelä Mikko, Shaaban Khaled A
(A1 Refereed original research article in a scientific journal)
Evolution-inspired engineering of anthracycline methyltransferases (2023)
- PNAS nexus
Dinis Pedro, Tirkkonen Heli, Nji Wandi Benjamin N, Siitonen Vilja, Niemi Jarmo, Grocholski Thadée, Metsä-Ketelä Mikko
(A1 Refereed original research article in a scientific journal)
Evolutionary Trajectories for the Functional Diversification of Anthracycline Methyltransferases (2019)
- ACS Chemical Biology
Grocholski T., Yamada K., Sinkkonen J., Tirkkonen H., Niemi J., Metsä-Ketelä M.
(A1 Refereed original research article in a scientific journal)