Hidehiro Iida
PhD in Physics from Univ of Tsukuba, PhD in Medical science from Tohoku Univ
Turku PET Center hidehiro.iida@utu.fi ORCID-tunniste: https://orcid.org/0000-0002-7914-3068 |
Instrumentation and modeling in PET, SPECT and medical imaging
Dr.
Hidehiro Iida has received PhD in Physics (Experimental Nuclear Physics) by the nuclear reaction mechanism in 1984, in which 2nd Born approximation formulation was verified based on hyper-polarized proton accelerated beams introducing (p,t) reactions. He has also contributed to develop a unique position-sensitive detector. He then joined a team at Research Institute for Brain and Blood Vessels, Akita, Japan, to develop a clinical PET scanner for quantitative assessment of cerebral and cardiovascular blood flow and metabolism. He lead an activity to develop three kinds of PET scanners which are for clinical use, including the Dual PET tomograph which scans both brain and heart simultaneously. He has also contributed to develop novel methodologies to quantitate regional myocardial perfusion, oxydative metabolism, which have been considered the gold standard in assesing in clinical populations. He then moved to National Cerebral and Cardiovascular Center - Research Institute, as a Director of Department of Investigated Radiology, in 1999. He and his colleagues developed a novel animal disease models of stroke, and cardiovascular diseases, together with the non-invasive methodologies to investigate their pathophysiology in PET, SPECT and MRI. He also contributed to make software and radio-labeled ligan producing devives to be approved as medical devices. They have been utilized in >400 clinical hospitals. He has an appointment to Turku PET Centre, and University of Turku in January, 2018, and continues to develop/improve the clinical methodology for assessing biological/physiological functional parametric images in vivo.
Dr.
Hidehiro Iida’s primary interest is the non-invasive imaging of
bio-physiological functions and molecular processes using PET, SPECT and MRI modalities.
He has been working on instrumentation and kinetic modeling-based
methodologies. and contributed to develop several methods to quantitatively
assess tissue perfusion, oxidative metabolism and other functions, in brain,
heart and other organs. Some of those techniques have been utilized in a number
of clinical researches as a gold standard, and also in clinical practice in
patients with cerebral and cardiovascular diseases.
Interest areas in teaching are as follows:
1. PET, SPECT and MR instrumentation
2. Mathematical modeling of biological processes to interprete the sequential PET, SPECT and MR images as an application of the inverse problem
3. To learn pathophysiology from PET, SPECT and MR images.
- Evaluation of a commercial PET tomograph-based system for the quantitative assessment of rCBF, rOEF and rCMRO(2) by using sequential administration of O-15-labeled compounds (2002)
- Annals of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Impact of attenuation and scatter correction in SPECT for quantification of cerebral blood flow using Tc-99m-ethyl cysteinate dimer (2002)
- IEEE Transactions on Nuclear Science
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Regional changes in human cerebral blood flow during dipyridamole stress: Neural activation in the thalamus and prefrontal cortex (2002)
- NeuroImage
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Arterial fraction of cerebral blood volume in humans measured by positron emission tomography (2001)
- Annals of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Clinical advantages of interictal SPECT coregistered to magnetic resonance imaging in patients with epilepsy (2001)
- Clinical Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Comparison of myocardial blood flow during dobutamine-atropine infusion with that after dipyridamole administration in normal men (2001)
- Journal of the American College of Cardiology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Development of a phoswich detector for a continuous blood-sampling system (2001)
- IEEE Transactions on Nuclear Science
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Reduced myocardial flow reserve relates to increased carotid intima-media thickness in healthy young men (2001)
- Atherosclerosis
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Regional myocardial metabolic rate of oxygen measured by O-2-15 inhalation and positron emission tomography in patients with cardiomyopathy (2001)
- Clinical Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - SPECT collimator dependency of scatter and validation of transmission-dependent scatter compensation methodologies (2001)
- IEEE Transactions on Nuclear Science
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Use of [C-11]acetate and [O-15]O-2 PET for the assessment of myocardial oxygen utilization in patients with chronic myocardial infarction (2001)
- European Journal of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Histochemical correlates of O-15-water-perfusable tissue fraction in experimental canine studies of old myocardial infarction (2000)
- Journal of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Myocardial efficiency during levosimendan infusion in congestive heart failure (2000)
- Clinical Pharmacology and Therapeutics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Noise reduction in PET attenuation correction using non-linear Gaussian filters (2000)
- IEEE Transactions on Nuclear Science
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Quantitation of regional cerebral blood flow corrected for partial volume effect using O-15 water and PET: II. Normal values and gray matter blood flow response to visual activation (2000)
- Journal of Cerebral Blood Flow and Metabolism
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Quantitation of regional cerebral blood flow corrected for partial volume effect using O-15 water and PET: I. Theory, error analysis, and stereologic comparison (2000)
- Journal of Cerebral Blood Flow and Metabolism
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Quantitative assessment of regional myocardial blood flow using oxygen-15-labelled water and positron emission tomography: a multicentre evaluation in Japan (2000)
- European Journal of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Regional differences in cerebral vascular response to P(a)co(2) changes in humans measured by positron emission tomography (2000)
- Journal of Cerebral Blood Flow and Metabolism
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Regional myocardial oxygen consumption estimated by carbon-11 acetate and positron emission tomography before and after repetitive ischemia (2000)
- Journal of Nuclear Cardiology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Coronary flow reserve in young men with familial combined hyperlipidemia (1999)
- Circulation
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )