Hidehiro Iida
PhD in Physics from Univ of Tsukuba, PhD in Medical science from Tohoku Univ
Turku PET Center hidehiro.iida@utu.fi ORCID identifier: https://orcid.org/0000-0002-7914-3068 |
Instrumentation and modeling in PET, SPECT and medical imaging
Dr.
Hidehiro Iida has received PhD in Physics (Experimental Nuclear Physics) by the nuclear reaction mechanism in 1984, in which 2nd Born approximation formulation was verified based on hyper-polarized proton accelerated beams introducing (p,t) reactions. He has also contributed to develop a unique position-sensitive detector. He then joined a team at Research Institute for Brain and Blood Vessels, Akita, Japan, to develop a clinical PET scanner for quantitative assessment of cerebral and cardiovascular blood flow and metabolism. He lead an activity to develop three kinds of PET scanners which are for clinical use, including the Dual PET tomograph which scans both brain and heart simultaneously. He has also contributed to develop novel methodologies to quantitate regional myocardial perfusion, oxydative metabolism, which have been considered the gold standard in assesing in clinical populations. He then moved to National Cerebral and Cardiovascular Center - Research Institute, as a Director of Department of Investigated Radiology, in 1999. He and his colleagues developed a novel animal disease models of stroke, and cardiovascular diseases, together with the non-invasive methodologies to investigate their pathophysiology in PET, SPECT and MRI. He also contributed to make software and radio-labeled ligan producing devives to be approved as medical devices. They have been utilized in >400 clinical hospitals. He has an appointment to Turku PET Centre, and University of Turku in January, 2018, and continues to develop/improve the clinical methodology for assessing biological/physiological functional parametric images in vivo.
Dr.
Hidehiro Iida’s primary interest is the non-invasive imaging of
bio-physiological functions and molecular processes using PET, SPECT and MRI modalities.
He has been working on instrumentation and kinetic modeling-based
methodologies. and contributed to develop several methods to quantitatively
assess tissue perfusion, oxidative metabolism and other functions, in brain,
heart and other organs. Some of those techniques have been utilized in a number
of clinical researches as a gold standard, and also in clinical practice in
patients with cerebral and cardiovascular diseases.
Interest areas in teaching are as follows:
1. PET, SPECT and MR instrumentation
2. Mathematical modeling of biological processes to interprete the sequential PET, SPECT and MR images as an application of the inverse problem
3. To learn pathophysiology from PET, SPECT and MR images.
- Advances in multimodal neuroimaging: Hybrid MR-PET and MR-PET-EEG at 3 T and 9.4 T (2013)
- Journal of Magnetic Resonance
(A1 Refereed original research article in a scientific journal) - Imaging of the appearance time of cerebral blood using [O-15]H2O PET for the computation of correct CBF (2013)
- EJNMMI Research
(A1 Refereed original research article in a scientific journal) - Implantation study of small-caliber "biotube" vascular grafts in a rat model (2013)
- Journal of Artificial Organs
(A1 Refereed original research article in a scientific journal) - Rapid quantitative CBF and CMRO2 measurements from a single PET scan with sequential administration of dual O-15-labeled tracers (2013)
- Journal of Cerebral Blood Flow and Metabolism
(A1 Refereed original research article in a scientific journal) - The Leptomeningeal Ivy Sign on Fluid-Attenuated Inversion Recovery Images in Moyamoya Disease: Positron Emission Tomography Study (2013)
- Cerebrovascular Diseases
(A1 Refereed original research article in a scientific journal) - Three-dimensional brain phantom containing bone and grey matter structures with a realistic head contour (2013)
- Annals of Nuclear Medicine
(A1 Refereed original research article in a scientific journal) - Verification of a semi-automated MRI-guided technique for non-invasive determination of the arterial input function in O-15-labeled gaseous PET (2013)
- Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
(A1 Refereed original research article in a scientific journal) - Breath-hold CT attenuation correction for quantitative cardiac SPECT (2012)
- EJNMMI Research
(A1 Refereed original research article in a scientific journal) - Cerebral blood flow and metabolism of hyperperfusion after cerebral revascularization in patients with moyamoya disease (2012)
- Journal of Cerebral Blood Flow and Metabolism
(A1 Refereed original research article in a scientific journal) - Determination of two-photon-excitation cross section for molecular isotope separation (2012)
- Journal of Molecular Spectroscopy
(A1 Refereed original research article in a scientific journal)



