Hidehiro Iida
PhD in Physics from Univ of Tsukuba, PhD in Medical science from Tohoku Univ
Turku PET Center hidehiro.iida@utu.fi ORCID identifier: https://orcid.org/0000-0002-7914-3068 |
Instrumentation and modeling in PET, SPECT and medical imaging
Dr.
Hidehiro Iida has received PhD in Physics (Experimental Nuclear Physics) by the nuclear reaction mechanism in 1984, in which 2nd Born approximation formulation was verified based on hyper-polarized proton accelerated beams introducing (p,t) reactions. He has also contributed to develop a unique position-sensitive detector. He then joined a team at Research Institute for Brain and Blood Vessels, Akita, Japan, to develop a clinical PET scanner for quantitative assessment of cerebral and cardiovascular blood flow and metabolism. He lead an activity to develop three kinds of PET scanners which are for clinical use, including the Dual PET tomograph which scans both brain and heart simultaneously. He has also contributed to develop novel methodologies to quantitate regional myocardial perfusion, oxydative metabolism, which have been considered the gold standard in assesing in clinical populations. He then moved to National Cerebral and Cardiovascular Center - Research Institute, as a Director of Department of Investigated Radiology, in 1999. He and his colleagues developed a novel animal disease models of stroke, and cardiovascular diseases, together with the non-invasive methodologies to investigate their pathophysiology in PET, SPECT and MRI. He also contributed to make software and radio-labeled ligan producing devives to be approved as medical devices. They have been utilized in >400 clinical hospitals. He has an appointment to Turku PET Centre, and University of Turku in January, 2018, and continues to develop/improve the clinical methodology for assessing biological/physiological functional parametric images in vivo.
Dr.
Hidehiro Iida’s primary interest is the non-invasive imaging of
bio-physiological functions and molecular processes using PET, SPECT and MRI modalities.
He has been working on instrumentation and kinetic modeling-based
methodologies. and contributed to develop several methods to quantitatively
assess tissue perfusion, oxidative metabolism and other functions, in brain,
heart and other organs. Some of those techniques have been utilized in a number
of clinical researches as a gold standard, and also in clinical practice in
patients with cerebral and cardiovascular diseases.
Interest areas in teaching are as follows:
1. PET, SPECT and MR instrumentation
2. Mathematical modeling of biological processes to interprete the sequential PET, SPECT and MR images as an application of the inverse problem
3. To learn pathophysiology from PET, SPECT and MR images.
- Low amyloid-beta deposition correlates with high education in cognitively normal older adults: a pilot study (2015)
- International Journal of Geriatric Psychiatry
(A1 Refereed original research article in a scientific journal) - Resting-state synchrony between the retrosplenial cortex and anterior medial cortical structures relates to memory complaints in subjective cognitive impairment (2015)
- Neurobiology of Aging
(A1 Refereed original research article in a scientific journal) - Adequacy of a compartment model for CMRO2 quantitation using O-15-labeled oxygen and PET: a clearance measurement of O-15-radioactivity following intracarotid bolus injection of O-15-labeled oxyhemoglobin on Macaca fascicularis (2014)
- Journal of Cerebral Blood Flow and Metabolism
(A1 Refereed original research article in a scientific journal) - Effects of Magnetic Fields of up to 9.4 T on Resolution and Contrast of PET Images as Measured with an MR-BrainPET (2014)
- PLoS ONE
(A1 Refereed original research article in a scientific journal) - Long-Term/Bioinert Labeling of Rat Mesenchymal Stem Cells with PVA-Gd Conjugates and MRI Monitoring of the Labeled Cell Survival after Intramuscular Transplantation (2014)
- Bioconjugate Chemistry
(A1 Refereed original research article in a scientific journal) - Microstructural abnormalities in white matter and their effect on depressive symptoms after stroke (2014)
- Psychiatry Research: Neuroimaging
(A1 Refereed original research article in a scientific journal) - Microstructural abnormality in white matter, regulatory T lymphocytes, and depressive symptoms after stroke (2014)
- Psychogeriatrics
(A1 Refereed original research article in a scientific journal) - Microstructural changes of the nucleus accumbens due to increase of estradiol level during menstrual cycle contribute to recurrent manic episodes-A single case study (2014)
- Psychiatry Research: Neuroimaging
(A1 Refereed original research article in a scientific journal) - PET Quantification of Cerebral Oxygen Metabolism in Small Animals (2014)
- ScientificWorld Journal
(A1 Refereed original research article in a scientific journal) - Quantification of myocardial blood flow using Tl-201 SPECT and population-based input function (2014)
- Annals of Nuclear Medicine
(A1 Refereed original research article in a scientific journal) - Quantitative assessment of rest and acetazolamide CBF using quantitative SPECT reconstruction and sequential administration of I-123-iodoamphetamine: comparison among data acquired at three institutions (2014)
- Annals of Nuclear Medicine
(A1 Refereed original research article in a scientific journal) - Validity of using a 3-dimensional PET scanner during inhalation of O-15-labeled oxygen for quantitative assessment of regional metabolic rate of oxygen in man (2014)
- Physics in Medicine and Biology
(A1 Refereed original research article in a scientific journal) - Advances in hybrid MR-PET at 3 T and 9.4 T in humans (2013)
- Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
(A1 Refereed original research article in a scientific journal) - Advances in multimodal neuroimaging: Hybrid MR-PET and MR-PET-EEG at 3 T and 9.4 T (2013)
- Journal of Magnetic Resonance
(A1 Refereed original research article in a scientific journal) - Imaging of the appearance time of cerebral blood using [O-15]H2O PET for the computation of correct CBF (2013)
- EJNMMI Research
(A1 Refereed original research article in a scientific journal) - Implantation study of small-caliber "biotube" vascular grafts in a rat model (2013)
- Journal of Artificial Organs
(A1 Refereed original research article in a scientific journal) - Rapid quantitative CBF and CMRO2 measurements from a single PET scan with sequential administration of dual O-15-labeled tracers (2013)
- Journal of Cerebral Blood Flow and Metabolism
(A1 Refereed original research article in a scientific journal) - The Leptomeningeal Ivy Sign on Fluid-Attenuated Inversion Recovery Images in Moyamoya Disease: Positron Emission Tomography Study (2013)
- Cerebrovascular Diseases
(A1 Refereed original research article in a scientific journal) - Three-dimensional brain phantom containing bone and grey matter structures with a realistic head contour (2013)
- Annals of Nuclear Medicine
(A1 Refereed original research article in a scientific journal) - Verification of a semi-automated MRI-guided technique for non-invasive determination of the arterial input function in O-15-labeled gaseous PET (2013)
- Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
(A1 Refereed original research article in a scientific journal)