Hidehiro Iida
PhD in Physics from Univ of Tsukuba, PhD in Medical science from Tohoku Univ
Turku PET Center hidehiro.iida@utu.fi ORCID identifier: https://orcid.org/0000-0002-7914-3068 |
Instrumentation and modeling in PET, SPECT and medical imaging
Dr.
Hidehiro Iida has received PhD in Physics (Experimental Nuclear Physics) by the nuclear reaction mechanism in 1984, in which 2nd Born approximation formulation was verified based on hyper-polarized proton accelerated beams introducing (p,t) reactions. He has also contributed to develop a unique position-sensitive detector. He then joined a team at Research Institute for Brain and Blood Vessels, Akita, Japan, to develop a clinical PET scanner for quantitative assessment of cerebral and cardiovascular blood flow and metabolism. He lead an activity to develop three kinds of PET scanners which are for clinical use, including the Dual PET tomograph which scans both brain and heart simultaneously. He has also contributed to develop novel methodologies to quantitate regional myocardial perfusion, oxydative metabolism, which have been considered the gold standard in assesing in clinical populations. He then moved to National Cerebral and Cardiovascular Center - Research Institute, as a Director of Department of Investigated Radiology, in 1999. He and his colleagues developed a novel animal disease models of stroke, and cardiovascular diseases, together with the non-invasive methodologies to investigate their pathophysiology in PET, SPECT and MRI. He also contributed to make software and radio-labeled ligan producing devives to be approved as medical devices. They have been utilized in >400 clinical hospitals. He has an appointment to Turku PET Centre, and University of Turku in January, 2018, and continues to develop/improve the clinical methodology for assessing biological/physiological functional parametric images in vivo.
Dr.
Hidehiro Iida’s primary interest is the non-invasive imaging of
bio-physiological functions and molecular processes using PET, SPECT and MRI modalities.
He has been working on instrumentation and kinetic modeling-based
methodologies. and contributed to develop several methods to quantitatively
assess tissue perfusion, oxidative metabolism and other functions, in brain,
heart and other organs. Some of those techniques have been utilized in a number
of clinical researches as a gold standard, and also in clinical practice in
patients with cerebral and cardiovascular diseases.
Interest areas in teaching are as follows:
1. PET, SPECT and MR instrumentation
2. Mathematical modeling of biological processes to interprete the sequential PET, SPECT and MR images as an application of the inverse problem
3. To learn pathophysiology from PET, SPECT and MR images.
- Influences of 3D PET scanner components on increased scatter evaluated by a Monte Carlo simulation (2017)
- Physics in Medicine and Biology
(A1 Refereed original research article in a scientific journal) - Microstructural Differences in the Corpus Callosum in Patients With Bipolar Disorder and Major Depressive Disorder (2017)
- Journal of Clinical Psychiatry
(A1 Refereed original research article in a scientific journal) - Sequential PET estimation of cerebral oxygen metabolism with spontaneous respiration of O-15-gas in mice with bilateral common carotid artery stenosis (2017)
- Journal of Cerebral Blood Flow and Metabolism
(A1 Refereed original research article in a scientific journal) - Significant correlation between openness personality in normal subjects and brain myelin mapping with T1/T2-weighted MR imaging (2017)
- Heliyon
(A1 Refereed original research article in a scientific journal) - Use of T1-weighted/T2-weighted magnetic resonance ratio to elucidate changes due to amyloid beta accumulation in cognitively normal subjects (2017) Yasuno F, Kazui H, Morita N, Kajimoto K, Ihara M, Taguchi A, Yamamoto A, Matsuoka K, Takahashi M, Nakagawara J, Iida H, Kishimoto T, Nagatsuka K
(A1 Refereed original research article in a scientific journal) - Association between chronic stress-induced structural abnormalities in Ranvier nodes and reduced oligodendrocyte activity in major depression (2016)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - A structural model of age, grey matter volumes, education, and personality traits (2016)
- Psychogeriatrics
(A1 Refereed original research article in a scientific journal) - Cerebral blood flow and metabolism associated with cerebral microbleeds in small vessel disease (2016)
- Annals of Nuclear Medicine
(A1 Refereed original research article in a scientific journal) - Development of in vivo tissue-engineered microvascular grafts with an ultra small diameter of 0.6 mm (MicroBiotubes): acute phase evaluation by optical coherence tomography and magnetic resonance angiography (2016)
- Journal of Artificial Organs
(A1 Refereed original research article in a scientific journal) - Effect of Attenuation Correction on Regional Quantification Between PET/MR and PET/CT: A Multicenter Study Using a 3-Dimensional Brain Phantom (2016)
- Journal of Nuclear Medicine
(A1 Refereed original research article in a scientific journal) - Gradual Carotid Artery Stenosis in Mice Closely Replicates Hypoperfusive Vascular Dementia in Humans (2016)
- Journal of the American Heart Association
(A1 Refereed original research article in a scientific journal) - High amyloid-beta deposition related to depressive symptoms in older individuals with normal cognition: a pilot study (2016)
- International Journal of Geriatric Psychiatry
(A1 Refereed original research article in a scientific journal) - Interhemispheric functional disconnection because of abnormal corpus callosum integrity in bipolar disorder type II (2016)
- BJPsych Open
(A1 Refereed original research article in a scientific journal) - Reduction in camera-specific variability in [I-123]FP-CIT SPECT outcome measures by image reconstruction optimized for multisite settings: impact on age-dependence of the specific binding ratio in the ENC-DAT database of healthy controls (2016)
- European Journal of Nuclear Medicine and Molecular Imaging
(A1 Refereed original research article in a scientific journal) - Substantial Reduction of Parenchymal Cerebral Blood Flow in Mice with Bilateral Common Carotid Artery Stenosis (2016)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - A Novel Mouse Model of Subcortical Infarcts with Dementia (2015)
- Journal of Neuroscience
(A1 Refereed original research article in a scientific journal) - Asymmetrical intersection between the middle cerebral artery and rhinal vein suggests asymmetrical gustatory cortex location in rodent hemispheres (2015)
- Neuroscience Letters
(A1 Refereed original research article in a scientific journal) - Combined PET/MRI: Multi-modality Multi-parametric Imaging Is Here (2015)
- Molecular Imaging and Biology
(A1 Refereed original research article in a scientific journal) - Delayed atrophy in posterior cingulate cortex and apathy after stroke (2015)
- International Journal of Geriatric Psychiatry
(A1 Refereed original research article in a scientific journal) - Intraperitoneal and intravenous deliveries are not comparable in terms of drug efficacy and cell distribution in neonatal mice with hypoxia ischemia (2015)
- Brain and Development
(A1 Refereed original research article in a scientific journal)