Jaakko Knuutila

- Doctoral Researcher,
- Clinical Lecturer
- Doctoral Candidate
Dermatology and Venereology (Department of Clinical Medicine)

jsknuu@utu.fi

Publications

C5aR1 Promotes Invasion, Metastasis, and Poor Prognosis in Cutaneous Squamous Cell Carcinoma (2025)
- American Journal of Pathology
Heiskanen, Lauri; Nissinen, Liisa; Siljamäki, Elina; Knuutila, Jaakko S.; Pellinen, Teijo; Kallajoki, Markku; Heino, Jyrki; Riihilä, Pilvi; Kähäri, Veli-Matti
(A1 Refereed original research article in a scientific journal)
Expression of C1q by Macrophages and Fibroblasts in Tumor Microenvironment Is Associated with Progression and Metastasis of Cutaneous Squamous Cell Carcinoma (2025)
- Journal of Investigative Dermatology
Viiklepp, Kristina; Knuutila, Jaakko S.; Nissinen, Liisa; Siljamäki, Elina; Rappu, Pekka; Suwal, Ujjwal; Pellinen, Teijo; Kallajoki, Markku; Meri, Seppo; Heino, Jyrki; Kähäri, Veli-Matti; Riihilä, Pilvi
(A1 Refereed original research article in a scientific journal)
Cancer-associated fibroblast activation predicts progression, metastasis, and prognosis of cutaneous squamous cell carcinoma (2024)
- International Journal of Cancer
Knuutila Jaakko S., Riihilä Pilvi, Nissinen Liisa, Heiskanen Lauri, Kallionpää Roosa E., Pellinen Teijo, Kähäri Veli-Matti

(A1 Refereed original research article in a scientific journal)
Clinical Risk Factors for Cutaneous Squamous Cell Carcinoma in Patients with Actinic Keratosis or Cutaneous Squamous Cell Carcinoma in Situ: A Retrospective Double-cohort Study (2024)
- Acta Dermato-Venereologica
Knuutila, Jaakko S.; Kaijala, Olli; Lehto, Salla; Vahlberg, Tero; Nissinen, Liisa; Kähäri, Veli-Matti; Riihilä, Pilvi
(A1 Refereed original research article in a scientific journal)
Ikääntyvän ihon muutosten ehkäisy ja hoito (2024)
- Duodecim
Riihilä, Pilvi; Knuutila, Jaakko; Kähäri, Veli-Matti
(A2 Refereed review article in a scientific journal )
Long noncoding RNA plasmacytoma variant translocation 1 is overexpressed in cutaneous squamous cell carcinoma and exon 2 is critical for its oncogenicity (2023)
- British Journal of Dermatology
Li Chen, Sun Chengxi, Mahapatra Kunal Das, Riihilä Pilvi, Knuutila Jaakko, Nissinen Liisa, Lapins Jan, Kähäri Veli-Matti, Homey Bernhard, Sonkoly Enikö, Pivarcsi Andor
(A1 Refereed original research article in a scientific journal)
Complement Factor D Is a Novel Biomarker and Putative Therapeutic Target in Cutaneous Squamous Cell Carcinoma (2022)
- Cancers
Nezhad Pegah Rahmati, Riihilä Pilvi, Knuutila Jaakko S., Viiklepp Kristiina, Peltonen Sirkku, Kallajoki Markku, Meri Seppo, Nissinen Liisa, Kähäri Veli-Matti
(A1 Refereed original research article in a scientific journal)
Identification of metastatic primary cutaneous squamous cell carcinoma utilizing artificial intelligence analysis of whole slide images (2022)
- Scientific Reports
Knuutila Jaakko S, Riihilä Pilvi, Karlsson Antti, Tukiainen Mikko, Talve Lauri, Nissinen Liisa, Kähäri Veli-Matti
(A1 Refereed original research article in a scientific journal)
Retrospective, Registry-based, Cohort Investigation of Clinical Outcomes in Patients with Cutaneous Squamous Cell Carcinoma and Basal Cell Carcinoma in Finland (2022)
- Acta Dermato-Venereologica
Tuominen Samuli, Ukkola-Vuoti Liisa, Riihilä Pilvi, Knuutila Jaakko S, Kähäri Veli-Matti, Lassenius Mariann, Ranki Tuuli, Pousar Katariina, Vassilev Lotta, Vuoti Sauli, Mattila Kalle
(A1 Refereed original research article in a scientific journal)
Risk factors and biomarkers for metastatic cutaneous squamous cell carcinoma (2022) Knuutila Jaakko

(G5 Article dissertation )
Super Enhancer-Regulated LINC00094 (SERLOC) Upregulates the Expression of MMP-1 and MMP-13 and Promotes Invasion of Cutaneous Squamous Cell Carcinoma (2022)
- Cancers
Piipponen Minna, Riihilä Pilvi, Knuutila Jaakko S, Kallajoki Markku, Kähäri Veli-Matti, Nissinen Liisa
(A1 Refereed original research article in a scientific journal)
Aikuisten yleisimmät ei-melanosyyttiperäiset ihokasvaimet (2021)
- Duodecim
Riihilä Pilvi, Knuutila Jaakko, Kähäri Veli-Matti
(A2 Refereed review article in a scientific journal )
Risk Factors and Prognosis for Metastatic Cutaneous Squamous Cell Carcinoma: A Cohort Study (2020)
- Acta Dermato-Venereologica
Jaakko Knuutila, Pilvi Riihilä, Samu Kurki, Liisa Nissinen, Veli-Matti Kähäri
(A1 Refereed original research article in a scientific journal)
Complement System in Cutaneous Squamous Cell Carcinoma (2019)
- International Journal of Molecular Sciences
Pilvi Riihilä, Liisa Nissinen, Jaakko Knuutila, Pegah Rahmati Nezhad, Kristina Viiklepp, Veli-Matti Kähäri
(A2 Refereed review article in a scientific journal )