Ulla Pentikäinen
FT, Dos
ulla.pentikainen@utu.fi +358 50 501 2574 Tykistökatu 6 Turku : 5090 |
Structural biology; X-ray crystallography; SAXS; protein-NMR; theoretical biophysics
I am structural biologists having a wide expertise in chemistry, biochemistry, protein chemistry, structural biology, and theoretical biophysics. I have gained this expertise by working in different research projects and groups both in Finland (University of Turku, University of Kuopio, University of Jyväskylä) and abroad (University of Bristol, UK, University of Illinois, USA). What I do not know yet, I can learn. I am interested in to understand how human diseases are developed at molecular level, what goes wrong at atomic, molecular, and protein level so that we got sick. This kind of research will help to develop new therapeutics towards different diseases, such various cancer types.
Why diseases are developed? What goes wrong at molecular level in our body so that we get sick? The aim of my group is to learn to understand the molecular and structural level the underlying mechanisms behind different human diseases. Currently, we are focused on 1) mitral valve disease caused by the mutations in a cytoskeletal protein Filamin, and 2) cancer types developed due to the inhibition of protein phosphates 2A by different proteins. In addition, we are interested in how mechanical forces are mediated and propagated in cells, crucial for tissue development and having important implications for various diseases such valvular diseases, osteoporosis, and cancer.
In our research, we employ various structural biology methods, such as X-ray crystallography, protein NMR-spectroscopy, SAXS, as well as different theoretical biophysical simulations including MD and SMD simulations.
- Wide teaching experience on biochemistry and chemistry
- Responsible teacher in various lecture- and laboratory courses both in Turku and Jyväskylä universities
- Responsible on study- and degree modules
- Teacher's pedagogic qualification
- University teacher's pedagogic qualification
- SHANK3 depletion leads to ERK signalling overdose and cell death in KRAS-mutant cancers (2024)
- Nature Communications
- Interaction mechanism of endogenous PP2A inhibitor protein ENSA with PP2A (2022)
- FEBS Journal
- The Interaction Mechanism of Intrinsically Disordered PP2A Inhibitor Proteins ARPP-16 and ARPP-19 With PP2A (2021)
- Frontiers in Molecular Biosciences
- 1H, 13C and 15N NMR chemical shift assignments of cAMP-regulated phosphoprotein-19 and -16 (ARPP-19 and ARPP-16) (2020)
- Biomolecular NMR Assignments
- Critical Structural Defects Explain Filamin A Mutations Causing Mitral Valve Dysplasia (2019)
- Biophysical Journal
- Non-syndromic Mitral Valve Dysplasia Mutation Changes the Force Resilience and Interaction of Human Filamin A. (2019)
- Structure
- Structural and Functional Insights Into Lysostaphin-Substrate Interaction (2018)
- Frontiers in Molecular Biosciences
- Skeletal Dysplasia Mutations Effect on Human Filamins' Structure and Mechanosensing (2017) Seppala J, Bernardi RC, Haataja TJK, Hellman M, Pentikainen OT, Schulten K, Permi P, Ylanne J, Pentikainen U
- Flexible Structure of Peptide-Bound Filamin A Mechanosensor Domain Pair 20-21 (2015) Seppala J, Tossavainen H, Rodic N, Permi P, Pentikainen U, Ylanne J
- A Novel Structural Unit in the N-terminal Region of Filamins (2014)
- Journal of Biological Chemistry
- Molecular mechanism of T-cell protein tyrosine phosphatase (TCPTP) activation by mitoxantrone (2013)
- BBA - Biochimica et Biophysica Acta
- Filamin's Force Sensing Mechanism Revealed by Optical Tweezers (2012)
- Biophysical Journal
- The C-terminal rod 2 fragment of filamin A forms a compact structure that can be extended (2012) Ruskamo S, Gilbert R, Hofmann G, Jiang PJ, Campbell ID, Ylanne J, Pentikainen U
- Assembly of a Filamin Four-domain Fragment and the Influence of Splicing Variant-1 on the Structure (2011)
- Journal of Biological Chemistry
- Novel Hydrazine Molecules as Tools To Understand the Flexibility of Vascular Adhesion Protein-1 Ligand-Binding Site: Toward More Selective Inhibitors (2011)
- Journal of Medicinal Chemistry
- Synthesis, in Vitro Activity, and Three-Dimensional Quantitative Structure-Activity Relationship of Novel Hydrazine Inhibitors of Human Vascular Adhesion Protein-1 (2010)
- Journal of Medicinal Chemistry
- Lennard-Jones Parameters for B3LYP/CHARMM27 QM/MM Modeling of Nucleic Acid Bases (2009)
- Journal of Chemical Theory and Computation
- The Regulation Mechanism for the Auto-Inhibition of Binding of Human Filamin A to Integrin (2009)
- Journal of Molecular Biology
- Cooperative symmetric to asymmetric conformational transition of the apo-form of scavenger decapping enzyme revealed by simulations (2008)
- Proteins
- Comment on "Molecular dynamics DFT : B3LYP study of guanosinetriphosphate conversion into guanosinemonophosphate upon Mg2+ chelation of alpha and beta phosphate oxygens of the triphosphate tail'' by Alexander A. Tulub, Phys. Chem. Chem. Phys., 2006, 8, 2187 (2006)
- Physical Chemistry Chemical Physics