Karolina Losenkova Mingeaud

MediCity (Faculty of Medicine)

karolina.losenkova@utu.fi

+358 29 450 4377

+358 50 514 2809

Tykistökatu 6

Turku

Publications

Adenosine metabolism in cancer: unveiling new therapeutic opportunities (2025) Losenkova Mingeaud, Karolina
(G5 Article dissertation )
CD73 controls ocular adenosine levels and protects retina from light-induced phototoxicity (2022)
- Cellular and Molecular Life Sciences
Losenkova Karolina, Takeda Akira, Ragauskas Symantas, Cerrada-Gimenez Marc, Vähätupa Maria, Kaja Simon, Paul Marius L., Schmies Constanze C., Rolshoven Georg, Müller Christa E., Sandholm Jouko, Jalkanen Sirpa, Kalesnykas Giedrius, Yegutkin Gennady G.
(A1 Refereed original research article in a scientific journal)
Structure-Activity Relationship of 3-Methylcytidine-5 '-alpha,beta-methylenediphosphates as CD73 Inhibitors (2022)
- Journal of Medicinal Chemistry
Scortichini Mirko, Idris Riham Mohammed, Moschutz Susanne, Keim Antje, Salmaso Veronica, Dobelmann Clemens, Oliva Paola, Losenkova Karolina, Irjala Heikki, Vaittinen Samuli, Sandholm Jouko, Yegutkin Gennady G, Sträter Norbert, Junker Anna, Müller Christa E, Jacobson Kenneth A
(A1 Refereed original research article in a scientific journal)
Structure activity relationship of 3-methylcytidine-5'-α,β-methylenediphosphates as CD73 inhibitors (2022)
- FASEB Journal
EB 2022 Jacobson Kenneth A., Scortichini Mirko, Idris Riham M., Moschütz Suzanne, Keim Antje, Salmaso Veronica A., Dobelmann Clemens, Oliva Paola A., Losenkova Karolina, Irjala Heikki, Vaittinen Samuli, Sandholm Jouko, Yegutkin Gennady G., Sträter Norbert, Junker Anna, Müller Christa E.
(Other publication)
Compartmentalization of adenosine metabolism in cancer cells and its modulation during acute hypoxia (2020)
- Journal of Cell Science
Losenkova K, Zuccarini M, Karikoski M, Laurila J, Boison D, Jalkanen S, Yegutkin GG
(A1 Refereed original research article in a scientific journal)
First person - Karolina Losenkova (2020)
- Journal of Cell Science
Losenkova Karolina
(Other publication)
Fluorescent Probes for Ecto-5 '-nucleotidase (CD73) (2020)
- ACS Medicinal Chemistry Letters
Schmies CC, Rolshoven G, Idris RM, Losenkova K, Renn C, Schakel L, Al-Hroub H, Wang YL, Garofano F, Schmidt-Wolf IGH, Zimmermann H, Yegutkin GG, Muller CE
(A1 Refereed original research article in a scientific journal)
Fully human anti-CD39 antibody potently inhibits ATPase activity in cancer cells via uncompetitive allosteric mechanism (2020)
- mAbs
Spatola BN, Lerner AG, Wong C, dela Cruz T, Welch M, Fung WC, Kovalenko M, Losenkova K, Yegutkin GG, Beers C, Corbin J, Soros VB
(A1 Refereed original research article in a scientific journal)
Histochemical approach for simultaneous detection of ectonucleotidase and alkaline phosphatase activities in tissues (2020) Purinergic Signaling Karolina Losenkova, Marius Paul, Heikki Irjala, Sirpa Jalkanen, Gennady G. Yegutkin
(A3 Refereed book chapter or chapter in a compilation book)
Use of Thrombodynamics for revealing the participation of platelet, erythrocyte, endothelial, and monocyte microparticles in coagulation activation and propagation (2020)
- PLoS ONE
E. N. Lipets, O. A. Antonova, O. N. Shustova, K. V. Losenkova, A. V. Mazurov, F. I. Ataullakhanov
(A1 Refereed original research article in a scientific journal)
Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage (2019)
- Journal of Molecular Medicine
Julian Zeiner, Sirpa Loukovaara, Karolina Losenkova, Mariachiare Zuccarini, Ani M. Korhonen, Kaisa Lehti, Anu Kauppinen, Kai Kaarniranta, Christa E. Muller, Sirpa Jalkanen, Gennady G. Yegutkin
(A1 Refereed original research article in a scientific journal)
Structure-Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5 '-Nucleotidase (CD73) Inhibitors (2019)
- Journal of Medicinal Chemistry
Junker A., Renn C., Dobelmann C., Namasivayam V., Jain S., Losenkova K., Irjala H., Duca S., Balasubramanian R., Chakraborty S., Börgel F., Zimmermann H., Yegutkin G.G., Müller C.E., Jacobson K.A.
(A1 Refereed original research article in a scientific journal)
Targeting CD39 with a first-in-class inhibitory antibody prevents ATP processing and increases T-cell activation (2019)
- Cancer Research
Lerner AG, Kovalenko M, Welch M, Dela Cruz T, Jones J, Wong C, Spatola B, Eberhardt M, Wong A, Fung W, Lagpacan L, Losenkova K, Yegutkin G, Soros V, Corbin J, Beers C, Moesta AK, Moesta AK
(Other publication)
Endothelial cells cope with hypoxia-induced depletion of ATP via activation of cellular purine turnover and phosphotransfer networks (2018)
- BBA - Molecular Basis of Disease
Karolina Losenkova, Mariachiara Zuccarini, Mikko Helenius, Guillaume Jacquemet, Evgenia Gerasimovskaya, Camilla Tallgren, Sirpa Jalkanen, Gennady G. Yegutkin
(A1 Refereed original research article in a scientific journal)
Regulation of intratumoral purine homeostasis and signaling via concerted action of alkaline phosphatases, CD39 and CD73 (2018)
- Purinergic Signalling
Losenkova K, Zeiner J, Kukkonen-Macchi A, Algars A, Sundstrom J, Jalkanen S, Yegutkin GG
(Other publication)