Partho Sen
 

    • dosentti
    biokemia (bioteknologian laitos)

Systems Medicine

partho.sen@utu.fi




ORCID-tunnistehttps://orcid.org/0000-0003-0475-2763

ResearchGate

My personal website

Google Scholar profile


Asiantuntijuusalueet
Machine Learning, Biomarker Discovery, R (Programming Language), Python (Programming Language), MATLAB, Snakemake, High Performance Computing (HPC), Computational Biology, Bioinformatics, Mathematical Modeling,
Statistical Modeling, Statistical Data Analysis, Metabolomics, Single Cell Sequencing, Functional Genomics, Transcriptomics, Metagenomics, NGS, Proteomics, Human Genetics.


Biografia

I've a 13-year background in computational biology and bioinformatics. My professional / research journey has been marked to unravel the intricacies of molecular signatures and processes in humans and microbes.

Currently specializing in precision and systems medicine, my focus centers on multiple myeloma and other cancer types. By utilization of multiomics (genomics, transcriptomics, proteomics and metabolomics) and clinical datasets, I tend to delineate cellular signatures and pathways associated with cancer, contributing to the biomarker discovery, and thereby attributing towards the cancer treatment.

My prior research has delved into diverse health conditions, including Diabetes (Type 1 & 2), Non-Alcoholic Fatty Liver Disease (NAFLD), Obesity, and Cardiovascular disease (Atherosclerosis). The overarching objective of my work is to identify molecular markers that serve as key insights into disease mechanisms and underlying pathways. Thereby, aim to formulate innovative drugs, inhibitors, and therapeutic strategies.

In addition to my proficiency in mathematical, statistical modeling and data science, I am an accomplished computer programmer; well-versed in machine learning. My passion lies in harnessing large datasets to design tools and methods that address contemporary challenges in healthcare, as well as cell and tissue biology.

I am confident that with my expertise, we can achieve significant breakthroughs in understanding and treating diseases that have hitherto posed significant challenges.



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  • Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease  (2022)  
    • Journal of Hepatology
     Sen Partho, Qadri Sami, Luukkonen Panu K, Ragnarsdottir Oddny, McGlincheyAidan , Jäntti Sirkku, Juuti Anne, Arola Johanna, Schlezinger Jennifer J, Webster Thomas F, Orešič Matej, Yki-Järvinen Hannele, Hyötyläinen Tuulia
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance  (2022)  
    • JHEP Reports
     Katherine Johnson, Peter J Leary, Olivier Govaere, Matthew J Barter, Sarah H Charlton, Simon J Cockell, Dina Tiniakos, Michalina Zatorska, Pierre Bedossa, M Julia Brosnan, Jeremy F Cobbold, Mattias Ekstedt, Guruprasad P Aithal, Karine Clément, Jörn M Schattenberg, Jerome Boursier, Vlad Ratziu, Elisabetta Bugianesi, Quentin M Anstee, Ann K Daly, on behalf of the
    LITMUS Consortium Investigators,

    James Clark, Heather J Cordell, Rebecca Darlay, Christopher P Day, Tim Hardy, Yang-Lin Liu, Fiona Oakley, Jeremy Palmer, Rachel Queen, Kristy Wonders, Patrick M Bossuyt, Adriaan G Holleboom, Hadi Zafarmand, Yasaman Vali, Jenny Lee, Karine Clement, Raluca Pais, Detlef Schuppan, Michael Allison, Sergio Rodriguez Cuenca, Vanessa Pellegrinelli, Michele Vacca, Antonio Vidal-Puig, Tuulia Hyötyläinen, Aidan McGlinchey, Matej Orešič, Partho Sen, Jose Mato, Óscar Millet, Jean-Francois Dufour, Stephen Harrison, Stefan Neubauer, Michael Pavlides, Ferenc Mozes, Salma Akhtar, Rajarshi Banerjee, Matt Kelly, Elizabeth Shumbayawonda, Andrea Dennis, Charlotte Erpicum, Manuel Romero-Gomez, Rocío Gallego-Durán, Isabel Fernández, Morten Karsdal, Diana Leeming, Mette Juul Fisker, Elisabeth Erhardtsen, Daniel Rasmussen, Per Qvist, Antonia Sinisi, Estelle Sandt, Maria Manuela Tonini, Maurizio Parola, Chiara Rosso, Fabio Marra, Amalia Gastaldelli, Sven Francque, Stergios Kechagias, Hannele Yki-Järvinen, Kimmo Porthan, Saskia van Mil, George Papatheodoridis, Helena Cortez-Pinto, Luca Valenti, Salvatore Petta, Luca Miele, Andreas Geier, Christian Trautwein, Paul Hockings, Phil Newsome, David Wenn, Cecília Maria Pereira Rodrigues, Rémy Hanf, Pierre Chaumat, Christian Rosenquist, Aldo Trylesinski, Pablo Ortiz, Kevin Duffin, Carla Yunis, Melissa Miller, Theresa Tuthill, Judith Ertle, Ramy Younes, Leigh Alexander, Rachel Ostroff, Mette Skalshøi Kjær, Lars Friis Mikkelsen, Clifford Brass, Lori Jennings, Maria-Magdalena Balp, Miljen Martic, Guido Hanauer, Sudha Shankar, Richard Torstenson, Céline Fournier, Richard Ehman, Michael Kalutkiewicz, Kay Pepin, Joel Myers, Diane Shevell, Gideon Ho, Henrik Landgren, Rob Myers, Lynda Doward, Diane Whalley, James Twiss

    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Metabolomic and proteomic profiling in bipolar disorder patients revealed potential molecular signatures related to hemostasis  (2022)  
    • Metabolomics
     Caracho Ribeiro Henrique, Sen Partho, Dickens Alex, Santa Cruz Elisa Castañeda, Orešič Matej, Sussulini Alessandra
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Quantitative modelling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease  (2022)  
    • iScience
     Sen Partho, Govaere Olivier, Sinioja Tim, McGlinchey Aidan, Geng Dawei, Ratziu Vlad, Bugianesi Elisabetta, Schattenberg Jörn M, Vidal-Puig Antonio, Allison Michael, Cockell Simon, Daly Ann K, Hyötyläinen Tuulia, Anstee Quentin M, Orešič Matej
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • 1‐deoxyceramides – key players in lipotoxicity and progression to type 2 diabetes?  (2021)  
    • Acta Physiologica
     Sen Partho, Hyötyläinen Tuulia, Orešič Matej
    (
    B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä )


  • Association Between Circulating Lipids and Future Weight Gain in Individuals With an At-Risk Mental State and in First-Episode Psychosis  (2021)  
    • Schizophrenia Bulletin
     Lamichhane Santosh, Dickens Alex M, Sen Partho, Laurikainen Heikki, Borgan Faith, Suvisaari Jaana, Hyötyläinen Tuulia, Howes Oliver, Hietala Jarmo, Orešič Matej
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species  (2021)  
    • Scientific Reports
     Petersen Anders Ø, Julienne Hanna, Hyötyläinen Tuulia, Sen Partho, Fan Yong, Krogh Pedersen Helle, Jäntti Sirkku, Hansen Tue H., Nielsen Trine, Jørgensen Torben, Hansen Torben, Myers Pernille Neve, Nielsen H. Bjørn, Ehrlich S. Dusko, Orešič Matej, Pedersen Oluf
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Deep learning meets metabolomics: a methodological perspective  (2021)  
    • Briefings in Bioinformatics
     Partho Sen, Santosh Lamichhane, Vivek B Mathema, Aidan McGlinchey, Alex M Dickens, Sakda Khoomrung, Matej Orešič
    (
    A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä)


  • Dysregulated lipid metabolism precedes onset of psychosis  (2021)  
    • Biological Psychiatry
     Alex M Dickens, Partho Sen, Matthew J Kempton, Neus Barrantes-Vidal, Conrad Iyegbe, Merete Nordentoft, Thomas Pollak, Anita Riecher-Rössler, Stephan Ruhrmann, Gabriele Sachs, Rodrigo Bressan, Marie-Odile Krebs, G Paul Amminger, Lieuwe de Haan, Mark van der Gaag, Lucia Valmaggia, Tuulia Hyötyläinen, Matej Orešič, Philip McGuire
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Linking Gut Microbiome and Lipid Metabolism: Moving beyond Associations  (2021)  
    • Metabolites
     Lamichhane Santosh, Sen Partho, Amaral Alves Marina, Ribeiro Henrique C, Raunioniemi Peppi, Hyötyläinen Tuulia, Orešič Matej
    (
    A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä)



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