A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Gut metabolome meets microbiome: A methodological perspective to understand the relationship between host and microbe
Tekijät: Santosh Lamichhane, Partho Sen, Alex M.Dickens, Matej Orešič, Hanne Christine Bertram
Kustantaja: Elsevier
Julkaisuvuosi: 2018
Journal: Methods
Tietokannassa oleva lehden nimi: Methods
Vuosikerta: 149
Aloitussivu: 3
Lopetussivu: 12
Sivujen määrä: 10
ISSN: 1046-2023
eISSN: 1095-9130
DOI: https://doi.org/10.1016/j.ymeth.2018.04.029
It is well established that gut microbes and their metabolic products
regulate host metabolism. The interactions between the host and its gut
microbiota are highly dynamic and complex. In this review we present and
discuss the metabolomic strategies to study the gut microbial
ecosystem. We highlight the metabolic profiling approaches to study
faecal samples aimed at deciphering the metabolic product derived from
gut microbiota. We also discuss how metabolomics data can be integrated
with metagenomics data derived from gut microbiota and how such
approaches may lead to better understanding of the microbial functions.
Finally, the emerging approaches of genome-scale metabolic modelling to
study microbial co-metabolism and host–microbe interactions are
highlighted.