Partho Sen
Machine Learning, Biomarker Discovery, R (Programming Language), Python (Programming Language), MATLAB, Snakemake, High Performance Computing (HPC), Computational Biology, Bioinformatics, Mathematical Modeling,
Statistical Modeling, Statistical Data Analysis, Metabolomics, Single Cell Sequencing, Functional Genomics, Transcriptomics, Metagenomics, NGS, Proteomics, Human Genetics.
I've a 13-year background in computational biology and bioinformatics. My professional / research journey has been marked to unravel the intricacies of molecular signatures and processes in humans and microbes.
Currently specializing in precision and systems medicine, my focus centers on multiple myeloma and other cancer types. By utilization of multiomics (genomics, transcriptomics, proteomics and metabolomics) and clinical datasets, I tend to delineate cellular signatures and pathways associated with cancer, contributing to the biomarker discovery, and thereby attributing towards the cancer treatment.
My prior research has delved into diverse health conditions, including Diabetes (Type 1 & 2), Non-Alcoholic Fatty Liver Disease (NAFLD), Obesity, and Cardiovascular disease (Atherosclerosis). The overarching objective of my work is to identify molecular markers that serve as key insights into disease mechanisms and underlying pathways. Thereby, aim to formulate innovative drugs, inhibitors, and therapeutic strategies.
In addition to my proficiency in mathematical, statistical modeling and data science, I am an accomplished computer programmer; well-versed in machine learning. My passion lies in harnessing large datasets to design tools and methods that address contemporary challenges in healthcare, as well as cell and tissue biology.
I am confident that with my expertise, we can achieve significant breakthroughs in understanding and treating diseases that have hitherto posed significant challenges.
- Early-life exposure to perfluorinated alkyl substances modulates lipid metabolism in progression to celiac diseaseHerring and chicken/pork meals lead to differences in plasma levels of TCA intermediates and arginine metabolites in overweight and obese men and women (2020)
- Environmental ResearchMolecular Nutrition and Food Research
- Metabolic alterations in immune cells associate with progression to type 1 diabetes (2020)
- Diabetologia
- Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes (2020)
- Environment International
- Metabolic Modeling of Human Gut Microbiota on a Genome Scale: An Overview (2019)
- Metabolites
- Metabolic profiling and compound-class identification reveal alterations in serum triglyceride levels in mice immunized with human vaccine adjuvant AlumQuantifying Diet-Induced Metabolic Changes of the Human Gut Microbiome (2019) Sakda Khoomrung, Intawat Nookaew, Partho Sen, Thorunn A Olafsdottir, Josefine Persson, Thomas Moritz, Peter Andersen, Ali M Harandi, Jens Nielsen
- Persistent Alterations in Plasma Lipid Profiles Before Introduction of Gluten in the Diet Associated With Progression to Celiac Disease (2019)
- Clinical and Translational Gastroenterology
- The Role of Omic Technologies in the Study of the Human Gut MicrobiomeKinetic modelling of phospholipid synthesis in Plasmodium knowlesi unravels crucial steps and relative importance of multiple pathways (2019) Reference Module in Food Science Partho Sen, Santosh Lamichhane, Alex M Dickens, Matej Orešič
- An Overview of Metabolomics Data Analysis: Current Tools and Future Perspectives (2018) Comprehensive Analytical Chemistry Lamichhane S., Sen P., Dickens A., Hyötyläinen T., Orešič M.
- Gut metabolome meets microbiome: A methodological perspective to understand the relationship between host and microbe (2018)
- Methods
- Perspectives on systems modeling of human peripheral blood mononuclear cells (2018)
- Frontiers in Molecular Biosciences
- Evaluation and assessment of read-mapping by multiple next-generation sequencing aligners based on genome-wide characteristics (2017)
- Genomics
- 2017
- Selection of complementary foods based on optimal nutritional values (2017)
- Scientific Reports
- Comparative Systems Analyses Reveal Molecular Signatures of Clinically tested Vaccine Adjuvants (2016) Olafsdottir TA, Lindqvist M, Nookaew I, Andersen P, Maertzdorf J, Persson J, Christensen D, Zhang Y, Anderson J, Khoomrung S, Sen P, Agger EM, Coler R, Carter D, Meinke A, Kaufmann SH, Rappuoli R, Harandi AM, Reed SG
- Mathematical Modeling and Omic Data Integration to Understand Dynamic Adaptation of Apicomplexan Parasites and Identify Pharmaceutical Targets (2016) Comprehensive Analysis of Parasite Biology: From Metabolism to Drug Discovery: From Metabolism to Drug Discovery Partho Sen, Henri J. Vial, Ovidiu Radulescu
- (2015)
- Cell Metabolism
- (2013)
- BMC Systems Biology