Anna Aakula - UTU Research Portal

Anna Aakula

Turku Bioscience Centre (Independent units)

anna.aakula@bioscience.fi

+358 29 450 3788

+358 50 571 3729

PP2A methylesterase PME-1 suppresses anoikis and is associated with therapy relapse of PTEN-deficient prostate cancers (2023)
- Molecular Oncology
Aakula Anna, Isomursu Aleksi, Rupp Christian, Erickson Andrew, Gupta Nikhil, Kauko Otto, Shah Pragya, Padzik Artur, Pokharel Yuba Raj, Kaur Amanpreet, Li Song-Ping, Trotman Lloyd, Taimen Pekka, Rannikko Antti, Lammerding Jan, Paatero Ilkka, Mirtti Tuomas, Ivaska Johanna, Westermarck Jukka
RAS and PP2A activities converge on epigenetic gene regulation (2023)
- Life Science Alliance
Aakula Anna, Sharma Mukund, Tabaro Francesco, Nätkin Reetta, Kamila Jesse, Honkanen Henrik, Schapira Matthieu, Arrowsmith Cheryl, Nykter Matti, Westermarck Jukka
Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A (2023)
- Nature Communications
Pavic Karolina, Gupta Nikhil, Omella Judit Domènech, Derua Rita, Aakula Anna, Huhtaniemi Riikka, Määttä Juha A, Höfflin Nico, Okkeri Juha, Wang Zhizhi, Kauko Otto, Varjus Roosa, Honkanen Henrik, Abankwa Daniel, Köhn Maja, Hytönen Vesa P, Xu Wenqing, Nilsson Jakob, Page Rebecca, Janssens Veerle, Leitner Alexander, Westermarck Jukka
Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1 (2020)
- Journal of Biological Chemistry
Kauko O, Imanishi SY, Kulesskiy E, Yetukuri L, Laajala TD, Sharma M, Pavic K, Aakula A, Rupp C, Jumppanen M, Haapaniemi P, Ruan L, Yadav B, Suni V, Varila T, Reimand J, Corthals GL, Aittokallio T, Wennerberg K, Westermarck J
Combined inhibition of tumor suppressors PTEN and PP2A drives anoikis resistance and is associated with therapy relapse in prostate cancer (2019)
- Cancer Research
Rupp C, Isomursu A, Aakula A, Erickson A, Li SP, Kaur A, Shah P, Pokharel YR, Trottman L, Lammerding J, Rannikko A, Taimen P, Mirtti T, Paatero I, Ivaska J, Westermarck JK
PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells (2018)
- Science Translational Medicine
Otto Kauko, Caitlin M. O’Connor, Evgeny Kulesskiy, Jaya Sangodkar, Anna Aakula, Sudeh Izadmehr, Laxman Yetukuri, Bhagwan Yadav, Artur Padzik, Teemu Daniel Laajala, Pekka Haapaniemi, Majid Momeny, Taru Varila, Michael Ohlmeyer, Tero Aittokallio, Krister Wennerberg, Goutham Narla, Jukka Westermarck
MicroRNA-135b regulates ERα, AR and HIF1AN and affects breast and prostate cancer cell growth (2015)
- Molecular Oncology
Anna Aakula, Suvi-Katri Leivonen, Petteri Hintsanen, Tero Aittokallio, Yvonne Ceder, Anne-Lise Børresen-Dale, Merja Perälä, Päivi östling, Olli Kallioniemi