PhD Heli Jokela - UTU Research Portal

Heli Jokela
PhD

- Senior Researcher,
Turku Bioscience Centre (Independent units)

Turku Bioscience

heli.jokela@utu.fi

Tykistökatu 6 B

Turku

: +358414626607

: https://orcid.org/https://orcid.org/0000-0003-1839-7870

Rantakari Group

@JokelaHeli

Immunology; Metabolism; Physiology; Endocrinology; Reproduction

Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance (2025)
- Cell Reports
Lehtonen, Henna; Jokela, Heli; Hofmann, Julian; Tola, Lauriina; Mehmood, Arfa; Ginhoux, Florent; Becher, Burkhard; Greter, Melanie; Yegutkin, Gennady G.; Salmi, Marko; Gerke, Heidi; Rantakari, Pia
Single-Cell Proteomics Reveals the Defined Heterogeneity of Resident Macrophages in White Adipose Tissue (2021)
- Frontiers in Immunology
Félix Inês, Jokela Heli, Karhula Joona, Kotaja Noora, Savontaus Eriika, Salmi Marko, Rantakari Pia
Fetal-derived macrophages persist and sequentially maturate in ovaries after birth in mice (2020)
- European Journal of Immunology
Heli Jokela, Emmi Lokka, Miikka Kiviranta, Sofia Tyystjärvi, Heidi Gerke, Kati Elima, Marko Salmi, Pia Rantakari
Hydroxysteroid (17β) dehydrogenase 1 expressed by Sertoli cells contributes to steroid synthesis and is required for male fertility (2018)
- FASEB Journal
Janne Hakkarainen, Fu-Ping Zhang, Heli Jokela, Artur Mayerhofer, Rüdiger Behr, Sheyla Cisneros-Montalvo, Mirja Nurmio, Jorma Toppari, Claes Ohlsson, Noora Kotaja, Petra Sipilä, and Matti Poutanen
Deleting the mouse Hsd17b1 gene results in a hypomorphic Naglu allele and a phenotype mimicking a lysosomal storage disease (2017)
- Scientific Reports
Jokela H, Hakkarainen J, Kätkänaho L, Pakarinen P, Ruohonen ST, Tena-Sempere M, Zhang FP, Poutanen M
Outcome of Hsd17b1 gene deletion in ovarian and adipose tissue function : alterations resulting from both HSD17B1 enzyme inhibition and the off-target effect on the Naglu gene (2017) Jokela Heli
Hydroxysteroid (17b)-dehydrogenase 1–deficient female mice present with normal puberty onset but are severely subfertile due to a defect in luteinization and progesterone production (2015)
- FASEB Journal
Janne Hakkarainen, Heli Jokela, Pirjo Pakarinen, Hanna Heikela, Laura Kätkänaho, Liesbeth Vandenput, Claes Ohlsson, Fu-Ping Zhang, and Matti Poutanen
The diversity of sex steroid action: novel functions of hydroxysteroid (17 beta) dehydrogenases as revealed by genetically modified mouse models (2012)
- Journal of Endocrinology
Saloniemi T, Jokela H, Strauss L, Pakarinen P, Poutanen M
Hydroxysteroid (17 beta) Dehydrogenase 7 Activity Is Essential for Fetal de Novo Cholesterol Synthesis and for Neuroectodermal Survival and Cardiovascular Differentiation in Early Mouse Embryos (2010)
- Endocrinology
Jokela H, Rantakari P, Lamminen T, Strauss L, Ola R, Mutka AL, Gylling H, Miettinen T, Pakarinen P, Sainio K, Poutanen M
Inactivation of Palb2 gene leads to mesoderm differentiation defect and early embryonic lethality in mice (2010)
- Human Molecular Genetics
Rantakari P, Nikkilä J, Jokela H, Ola R, Pylkäs K, Lagerbohm H, Sainio K, Poutanen M, Winqvist R
Novel hydroxysteroid (17 β) dehydrogenase 1 inhibitors reverse estrogen-induced endometrial hyperplasia in transgenic mice (2010)
- American Journal of Pathology
Saloniemi T, Järvensivu P, Koskimies P, Jokela H, Lamminen T, Ghaem-Maghami S, Dina R, Damdimopoulou P, Mäkelä S, Perheentupa A, Kujari H, Brosens J, Poutanen M