Hannu Aro
Professor
hannu.aro@utu.fi +358 40 353 7644 Hämeentie 11 Turku |
Orthopaedic Surgery; Hip replacement; Osteoporosis; Radiostereometric analysis of joint implant healing; PET imaging of infections
I am an academic Orthopaedic Surgeon with the clinical license both in Finland and in USA. I have a strong basic science background on the biomechanics and molecular biology of bone healing as well as on biomaterial incorporation with bone. I have supervised 15 PhD theses on these subjects and I have more than 170 original publications. During the past 15 years in collaboration with leading international companies and Finnish start-up companies, I have focused on the randomized phase I-IV clinical trials on fracture patients and hip replacement patients, applying advanced imaging technology (RSA, radiostereometric analysis). In everyday clinical practice, I am nowadays focused on bone tumor surgery and hip/knee replacements. Among University duties, I am in charge of the resident program in orthopaedic surgery and traumatology.
Currently, my main clinical research interest is in osteoporosis and prevention of periprosthetic fractures in postmenopausal women and in replacement of human allogeneic bone grafts by bioresorbable synthetic substitutes. In addition, we have had an interest in the development of PET/CT imaging technology for detection of indolent periprosthetic infections.
Orthopaedic Surgery and Traumatology; Resident Education
- Comparison of the osteogenic capacity of minipig and human bone marrow-derived mesenchymal stem cells (2012)
- Journal of Orthopaedic Research
- Low BMD affects initial stability and delays stem osseointegration in cementless total hip arthroplasty in women: a 2-year RSA study of 39 patients (2012)
- Acta Orthopaedica
- MicroRNAs miR-96, miR-124, and miR-199a regulate gene expression in human bone marrow-derived mesenchymal stem cells. (2012)
- Journal of Cellular Biochemistry
- Osteoclasts derived from patients with neurofibromatosis 1 (NF1) display insensitivity to bisphosphonates in vitro (2012)
- BONE
- Polysaccharide-coated thermosets for orthopedic applications: from material characterization to in vivo tests (2012)
- Biomacromolecules
- Radiostereometric analysis in measurements of migration and inducible micromotion in intra-articular distal radius fractures treated with a volar plate (2012)
- Journal of Orthopaedic Trauma
- Transient 100 nM dexamethasone treatment reduces inter- and intraindividual variations in osteoblastic differentiation of bone marrow-derived human mesenchymal stem cells (2012)
- Tissue Engineering Part C Methods
- Instrumented Spondylodesis in Degenerative Spondylolisthesis With Bioactive Glass and Autologous Bone A Prospective 11-year Follow-up (2011)
- Journal of Spinal Disorders and Techniques
- INTERACTION BETWEEN MARROW-DERIVED HUMAN MESENCHYMAL STEM CELLS AND PERIPHERAL BLOOD MONONUCLEAR CELLS IN ENDOTHELIAL CELL DIFFERENTIATION (2011)
- Scandinavian Journal of Surgery
- In vivo and in vitro study of a polylactide-fiber-reinforced β-tricalcium phosphate composite cage in an ovine anterior cervical intercorporal fusion model (2011)
- International Journal of Biomaterials
- Micro-RNAs regulate the differentiation of human bone marrow-derived MSCs (2011)
- BONE
- PET imaging of blood flow and glucose metabolism in localized musculoskeletal tumors of the extremities (2011)
- Nuclear Medicine and Biology
- A 6-months, randomised, placebo-controlled evaluation of efficacy and tolerability of 7-day buprenorphine transdermal patch in osteoarthritis patients naïve to potent-opioids (2010)
- Scandinavian Journal of Pain
- Bioceramic inlays do not improve mechanical incorporation of grit-blastedtitanium stems in the proximal sheep fumur (2010)
- Journal of Biomedical Materials Research Part A
- Circulating plastic adherent mesenchymal stem cells in aged hip fracture patients (2010)
- Journal of Orthopaedic Research
- Comparison of bioactive glasses in vitro and in vivo. Glass Technology (2010)
- European Journal of Glass Science and Technology Part a Glass Technology
- Expression of ezrin, Bcl-2, and Ki-67 in chondrosarcomas (2010)
- APMIS
- Female patients with low systemic BMD (2010)
- Acta Orthopaedica
- In vivo testing of a biodegradable woven fabric made of bioactive glass fibers and PLGA80--a pilot study in the rabbit (2010)
- Journal of Biomedical Materials Research Part B: Applied Biomaterials
- Female patients with low systemic BMD are prone to bone loss in Gruen zone 7 after cementless total hip arthroplasty A 2-year DXA follow-up of 39 patients (2009)
- Acta Orthopaedica