Johanna Schleutker
PhD, Professor of Medical Genetics
Areas of expertise
Cancer genetics; hereditary cancer; genomics; human genetics
Biography
Johanna Schleutker got her PhD in 1995 in University of Turku, Faculty of Medicine.The topic of her doctoral thesis was "Linkage disequilibrium is Salla disease; positioning of the sialic acid transport defect". She then moved to University of Tampere, and did her post doc in 1996-1998 in the Cancer Genetics research group of Professor Olli Kallioniemi. Her career continued in the US where she spent the years of 1999-2000 working as a research associate at the National Human Genome Research Institute, National Institutes of Health, Bethesda, MD. During the NIH years, she studied genetics of familial prostate cancer in the group of Dr. Jeffrey M.Trent. After her return to Finland, Schleutker started her own research group in 2001 at the Insitute of Medical Technology, University of Tampere, and has ever since focused her studies on genetics and genetic susceptibility of prostate and breast cancer. Schleutker got a professorship in University of Tampere in 2008. In 2011 she started as a professor of medical genetics in University of Turku.
Research
The Schleutker group "Genetic Predisposition to Cancer" is studying both breast and prostate cancer genetics, the main emphasis being on prostate cancer. Of all cancers, prostate cancer (PrCa) has been reported as one of the most heritable diseases: genetic factors have been estimated to account for 57% of the risk. The goal is to identify and characterize predisposing genes and variants, especially those affecting aggressive outcome, including treatment responses to therapies. Further, the aim is to develop tools for prognostic purposes, i.e. prognostic biomarkers. The group has identified many significant genomic risk regions, candidate genes and variants, which have been then further profiled and characterized by functional studies. The group has produced (by 2021) 12 PhD degrees and published over 190 original, peer-reviewed articles in international journals.
Teaching
Genetics, cancer genetics, hereditary cancer, genomics, molecular biology.
Publications
- Risk Prediction of Prostate Cancer with Single Nucleotide Polymorphisms and Prostate Specific Antigen (2019) Li-Sheng Chen S., Ching-Yuan Fann J., Sipeky C., Yang T.-K., Yueh-Hsia Chiu S., Ming-Fang Yen A., Laitinen V., Tammela T.L.J., Stenman U.-H., Auvinen A., Schleutker J., Chen H.-H.
(A1 Refereed original research article in a scientific journal)
- Runs of homozygosity and testicular cancer risk (2019) C. Loveday, A. Sud K. Litchfield, M. Levy, A. Holroyd, P. Broderick, Z. Kote‐Jarai, A. M. Dunning, K. Muir, J. Peto, R. Eeles, D. F. Easton, D. Dudakia, N. Orr, N. Pashayan; UK Testicular Cancer Collaboration; The PRACTICAL Consortium; A. Reid, R. A. Huddart, R. S. Houlston, C. Turnbull
(A1 Refereed original research article in a scientific journal)
- Shared heritability and functional enrichment across six solid cancers (2019) Xia Jiang, Hilary K. Finucane, Fredrick R. Schumacher, Stephanie L. Schmit, Jonathan P. Tyrer, Younghun Han, Kyriaki Michailidou, Corina Lesseur, Karoline B. Kuchenbaecker, Joe Dennis, David V. Conti, Graham Casey, Mia M. Gaudet, Jeroen R. Huyghe, Demetrius Albanes, Melinda C. Aldrich, Angeline S. Andrew, Irene L. Andrulis, Hoda Anton-Culver, Antonis C. Antoniou, Natalia N. Antonenkova, Susanne M. Arnold, Kristan J. Aronson, Banu K. Arun, Elisa V. Bandera, Rosa B. Barkardottir, Daniel R. Barnes, Jyotsna Batra, Matthias W. Beckmann, Javier Benitez, Sara Benlloch, Andrew Berchuck, Sonja I. Berndt, Heike Bickeböller, Stephanie A. Bien, Carl Blomqvist, Stefania Boccia, Natalia V. Bogdanova, Stig E. Bojesen, Manjeet K. Bolla, Hiltrud Brauch, Hermann Brenner, James D. Brenton, Mark N. Brook, Joan Brunet, Hans Brunnström, Daniel D. Buchanan, Barbara Burwinkel, Ralf Butzow, Gabriella Cadoni, Trinidad Caldés, Maria A. Caligo, Ian Campbell, Peter T. Campbell, Géraldine Cancel-Tassin, Lisa Cannon-Albright, Daniele Campa, Neil Caporaso, André L. Carvalho, Andrew T. Chan, Jenny Chang-Claude, Stephen J. Chanock, Chu Chen, David C. Christiani, Kathleen B. M. Claes, Frank Claessens, Judith Clements, J. Margriet Collée, Marcia Cruz Correa, Fergus J. Couch, Angela Cox, Julie M. Cunningham, Cezary Cybulski, Kamila Czene, Mary B. Daly, Anna deFazio, Peter Devilee, Orland Diez, Manuela Gago-Dominguez, Jenny L. Donovan, Thilo Dörk, Eric J. Duell, Alison M. Dunning, Miriam Dwek, Diana M. Eccles, Christopher K. Edlund, Digna R Velez Edwards, Carolina Ellberg, D. Gareth Evans, Peter A. Fasching, Robert L. Ferris, Triantafillos Liloglou, Jane C. Figueiredo, Olivia Fletcher, Renée T. Fortner, Florentia Fostira, Silvia Franceschi, Eitan Friedman, Steven J. Gallinger, Patricia A. Ganz, Judy Garber, José A. García-Sáenz, Simon A. Gayther, Graham G. Giles, Andrew K. Godwin, Mark S. Goldberg, David E. Goldgar, Ellen L. Goode, Marc T. Goodman, Gary Goodman, Kjell Grankvist, Mark H. Greene, Henrik Gronberg, Jacek Gronwald, Pascal Guénel, Niclas Håkansson, Per Hall, Ute Hamann, Freddie C. Hamdy, Robert J. Hamilton, Jochen Hampe, Aage Haugen, Florian Heitz, Rolando Herrero, Peter Hillemanns, Michael Hoffmeister, Estrid Høgdall, Yun-Chul Hong, John L. Hopper, Richard Houlston, Peter J. Hulick, David J. Hunter, David G. Huntsman, Gregory Idos, Evgeny N. Imyanitov, Sue Ann Ingles, Claudine Isaacs, Anna Jakubowska, Paul James, Mark A. Jenkins, Mattias Johansson, Mikael Johansson, Esther M. John, Amit D. Joshi, Radka Kaneva, Beth Y. Karlan, Linda E. Kelemen, Tabea Kühl, Kay-Tee Khaw, Elza Khusnutdinova, Adam S. Kibel, Lambertus A. Kiemeney, Jeri Kim, Susanne K. Kjaer, Julia A. Knight, Manolis Kogevinas, Zsofia Kote-Jarai, Stella Koutros, Vessela N. Kristensen, Jolanta Kupryjanczyk, Martin Lacko, Stephan Lam, Diether Lambrechts, Maria Teresa Landi, Philip Lazarus, Nhu D. Le, Eunjung Lee, Flavio Lejbkowicz, Heinz-Josef Lenz, Goska Leslie, Davor Lessel, Jenny Lester, Douglas A. Levine, Li Li, Christopher I. Li, Annika Lindblom, Noralane M. Lindor, Geoffrey Liu, Fotios Loupakis, Jan Lubiński, Lovise Maehle, Christiane Maier, Arto Mannermaa, Loic Le Marchand, Sara Margolin, Taymaa May, Lesley McGuffog, Alfons Meindl, Pooja Middha, Austin Miller, Roger L. Milne, Robert J. MacInnis, Francesmary Modugno, Marco Montagna, Victor Moreno, Kirsten B. Moysich, Lorelei Mucci, Kenneth Muir, Anna Marie Mulligan, Katherine L. Nathanson, David E. Neal, Andrew R. Ness, Susan L. Neuhausen, Heli Nevanlinna, Polly A. Newcomb, Lisa F. Newcomb, Finn Cilius Nielsen, Liene Nikitina-Zake, Børge G. Nordestgaard, Robert L. Nussbaum, Kenneth Offit, Edith Olah, Ali Amin Al Olama, Olufunmilayo I. Olopade, Andrew F. Olshan, Håkan Olsson, Ana Osorio, Hardev Pandha, Jong Y. Park, Nora Pashayan, Michael T. Parsons, Tanja Pejovic, Kathryn L. Penney, Wilbert H M. Peters, Catherine M. Phelan, Amanda I. Phipps, Dijana Plaseska-Karanfilska, Miranda Pring, Darya Prokofyeva, Paolo Radice, Kari Stefansson, Susan J. Ramus, Leon Raskin, Gad Rennert, Hedy S. Rennert, Elizabeth J. van Rensburg, Marjorie J. Riggan, Harvey A. Risch, Angela Risch, Monique J. Roobol, Barry S. Rosenstein, Mary Anne Rossing, Kim De Ruyck, Emmanouil Saloustros, Dale P. Sandler, Elinor J. Sawyer, Matthew B. Schabath, Johanna Schleutker, Marjanka K. Schmidt, V. Wendy Setiawan, Hongbing Shen, Erin M. Siegel, Weiva Sieh, Christian F. Singer, Martha L. Slattery, Karina Dalsgaard Sorensen, Melissa C. Southey, Amanda B. Spurdle, Janet L. Stanford, Victoria L. Stevens, Sebastian Stintzing, Jennifer Stone, Karin Sundfeldt, Rebecca Sutphen, Anthony J. Swerdlow, Eloiza H. Tajara, Catherine M. Tangen, Adonina Tardon, Jack A. Taylor, M. Dawn Teare, Manuel R. Teixeira, Mary Beth Terry, Kathryn L. Terry, Stephen N. Thibodeau, Mads Thomassen, Line Bjørge, Marc Tischkowitz, Amanda E. Toland, Diana Torres, Paul A. Townsend, Ruth C. Travis, Nadine Tung, Shelley S. Tworoger, Cornelia M. Ulrich, Nawaid Usmani, Celine M. Vachon, Els Van Nieuwenhuysen, Ana Vega, Miguel Elías Aguado-Barrera, Qin Wang, Penelope M. Webb, Clarice R. Weinberg, Stephanie Weinstein, Mark C. Weissler, Jeffrey N. Weitzel, Catharine M. L. West, Emily White, Alice S. Whittemore, H-Erich Wichmann, Fredrik Wiklund, Robert Winqvist, Alicja Wolk, Penella Woll, Michael Woods, Anna H. Wu, Xifeng Wu, Drakoulis Yannoukakos, Wei Zheng, Shanbeh Zienolddiny, Argyrios Ziogas, Kristin K. Zorn, Jacqueline M. Lane, Richa Saxena, Duncan Thomas, Rayjean J. Hung, Brenda Diergaarde, James McKay, Ulrike Peters, Li Hsu, Montserrat García-Closas, Rosalind A. Eeles, Georgia Chenevix-Trench, Paul J. Brennan, Christopher A. Haiman, Jacques Simard, Douglas F. Easton, Stephen B. Gruber, Paul D. P. Pharoah, Alkes L. Price, Bogdan Pasaniuc, Christopher I. Amos, Peter Kraft, Sara Lindström
(A1 Refereed original research article in a scientific journal)
- Syövän perinnöllisyys (2019) Kankuri-Tammilehto Minna, Vihinen Pia, Schleutker Johanna
(A2 Refereed review article in a scientific journal )
- AA9int: SNP interaction pattern search using non-hierarchical additive model set (2018) Hui-Yi Lin, Po-Yu Huang, Dung-Tsa Chen, Heng-Yuan Tung, Thomas A. Sellers, Julio M. Pow-Sang, Rosalind Eeles, Doug Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham G. Giles, Fredrik Wiklund,
Henrik Gronberg, Christopher A. Haiman, Johanna Schleutker, Børge G. Nordestgaard, Ruth C. Travis, Freddie Hamdy, David E. Neal, Nora Pashayan, Kay-Tee Khaw, Janet L. Stanford,William J. Blot, Stephen N. Thibodeau, Christiane Maier, Adam S. Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Radka Kaneva, Jyotsna Batra,Manuel R. Teixeira, Hardev Pandha, Yong-Jie Lu, The PRACTICAL Consortium, Jong Y. Park
(A1 Refereed original research article in a scientific journal)
- ANO7 is associated with aggressive prostate cancer (2018)
- International Journal of Cancer
Kaikkonen E., Rantapero T., Zhang Q., Taimen P., Laitinen V., Kallajoki M., Jambulingam D., Ettala O., Knaapila J., Boström P., Wahlström G., Sipeky C., Pursiheimo J., Tammela T., Kellokumpu-Lehtinen P., Fey V., Maehle L., Wiklund F., Wei G., Schleutker J.
(A1 Refereed original research article in a scientific journal)
- Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci (2018) Schumacher FR, Al Olama AA, Berndt SI, Benlloch S, Ahmed M, Saunders EJ, Dadaev T, Leongamornlert D, Anokian E, Cieza-Borrella C, Goh C, Brook MN, Sheng X, Fachal L, Dennis J, Tyrer J, Muir K, Lophatananon A, Stevens VL, Gapstur SM, Carter BD, Tangen CM, Goodman PJ, Thompson IM, Batra J, Chambers S, Moya L, Clements J, Horvath L, Tilley W, Risbridger GP, Gronberg H, Aly M, Nordstrom T, Pharoah P, Pashayan N, Schleutker J, Tammela TLJ, Sipeky C, Auvinen A, Albanes D, Weinstein S, Wolk A, Hakansson N, West CML, Dunning AM, Burnet N, Mucci LA, Giovannucci E, Andriole GL, Cussenot O, Cancel-Tassin G, Koutros S, Freeman LEB, Sorensen KD, Orntoft TF, Borre M, Maehle L, Grindedal EM, Neal DE, Donovan JL, Hamdy FC, Martin RM, Travis RC, Key TJ, Hamilton RJ, Fleshner NE, Finelli A, Ingles SA, Stern MC, Rosenstein BS, Kerns SL, Ostrer H, Lu YJ, Zhang HW, Feng NH, Mao XY, Guo X, Wang GM, Sun Z, Giles GG, Southey MC, MacInnis RJ, FitzGerald LM, Kibel AS, Drake BF, Vega A, Gomez-Caamano A, Szulkin R, Eklund M, Kogevinas M, Llorca J, Castano-Vinyals G, Penney KL, Stampfer M, Park JY, Sellers TA, Lin HY, Stanford JL, Cybulski C, Wokolorczyk D, Lubinski J, Ostrander EA, Geybels MS, Nordestgaard BG, Nielsen SF, Weischer M, Bisbjerg R, Roder MA, Iversen P, Brenner H, Cuk K, Holleczek B, Maier C, Luedeke M, Schnoeller T, Kim J, Logothetis CJ, John EM, Teixeira MR, Paulo P, Cardoso M, Neuhausen SL, Steele L, Ding YC, De Ruyck K, De Meerleer G, Ost P, Razack A, Lim J, Teo SH, Lin DW, Newcomb LF, Lessel D, Gamulin M, Kulis T, Kaneva R, Usmani N, Singhal S, Slavov C, Mitev V, Parliament M, Claessens F, Joniau S, Van den Broeck T, Larkin S, Townsend PA, Aukim-Hastie C, Dominguez MG, Castelao JE, Martinez ME, Roobol MJ, Jenster G, van Schaik RHN, Menegaux F, Truong T, Koudou YA, Xu JF, Khaw KT, Cannon-Albright L, Pandha H, Michael A, Thibodeau SN, McDonnell SK, Schaid DJ, Lindstrom S, Turman C, Ma J, Hunter DJ, Riboli E, Siddiq A, Canzian F, Kolonel LN, Le Marchand L, Hoover RN, Machiela MJ, Cui ZX, Kraft P, Conti DV, Easton DF, Wiklund F, Chanock SJ, Henderson BE, Kote-Jarai Z, Haiman CA, Eeles RA
(A1 Refereed original research article in a scientific journal)
- Biology and Clinical Implications of the 19q13 Aggressive Prostate Cancer Susceptibility Locus (2018) Ping Gao, Ji-Han Xia, Csilla Sipeky, Xiao-Ming Dong, Qin Zhang, Yuehong Yang, Peng Zhang, Sara Pereira Cruz, Kai Zhang, Jing Zhu, Hang-Mao Lee, Sufyan Suleman, Nikolaos Giannareas, Song Liu, Teuvo L.J. Tammela, Anssi Auvinen, Xiaoyue Wang, Qilai Huang, Liguo Wang, Aki Manninen, Markku H. Vaarala, Liang Wang, Johanna Schleutker, Gong-Hong Wei; The PRACTICAL Consortium
(A1 Refereed original research article in a scientific journal)
- Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants (2018) Dadaev T, Saunders EJ, Newcombe PJ, Anokian E, Leongamornlert DA, Brook MN, Cieza-Borrella C, Mijuskovic M, Wakerell S, Al Olama AA, Schumacher FR, Berndt SI, Benlloch S, Ahmed M, Goh C, Sheng X, Zhang Z, Muir K, Govindasami K, Lophatananon A, Stevens VL, Gapstur SM, Carter BD, Tangen CM, Goodman P, Thompson IM, Batra J, Chambers S, Moya L, Clements J, Horvath L, Tilley W, Risbridger G, Gronberg H, Aly M, Nordstrom T, Pharoah P, Pashayan N, Schleutker J, Tammela TLJ, Sipeky C, Auvinen A, Albanes D, Weinstein S, Wolk A, Hakansson N, West C, Dunning AM, Burnet N, Mucci L, Giovannucci E, Andriole G, Cussenot O, Cancel-Tassin G, Koutros S, Freeman LEB, Sorensen KD, Orntoft TF, Borre M, Maehle L, Grindedal EM, Neal DE, Donovan JL, Hamdy FC, Martin RM, Travis RC, Key TJ, Hamilton RJ, Fleshner NE, Finelli A, Ingles SA, Stern MC, Rosenstein B, Kerns S, Ostrer H, Lu YJ, Zhang HW, Feng N, Mao X, Guo X, Wang GM, Sun Z, Giles GG, Southey MC, MacInnis RJ, FitzGerald LM, Kibel AS, Drake BF, Vega A, Gomez-Caamano A, Fachal L, Szulkin R, Eklund M, Kogevinas M, Llorca J, Castano-Vinyals G, Penney KL, Stampfer M, Park JY, Sellers TA, Lin HY, Stanford JL, Cybulski C, Wokolorczyk D, Lubinski J, Ostrander EA, Geybels MS, Nordestgaard BG, Nielsen SF, Weisher M, Bisbjerg R, Roder MA, Iversen P, Brenner H, Cuk K, Holleczek B, Maier C, Luedeke M, Schnoeller T, Kim J, Logothetis CJ, John EM, Teixeira MR, Paulo P, Cardoso M, Neuhausen SL, Steele L, Ding YC, De Ruyck K, De Meerleer G, Ost P, Razack A, Lim J, Teo SH, Lin DW, Newcomb LF, Lessel D, Gamulin M, Kulis T, Kaneva R, Usmani N, Slavov C, Mitev V, Parliament M, Singhal S, Claessens F, Joniau S, Van den Broeck T, Larkin S, Townsend PA, Aukim-Hastie C, Gago-Dominguez M, Castelao JE, Martinez ME, Roobol MJ, Jenster G, van Schaik RHN, Menegaux F, Truong T, Koudou YA, Xu JF, Khaw KT, Cannon-Albright L, Pandha H, Michael A, Kierzek A, Thibodeau SN, McDonnell SK, Schaid DJ, Lindstrom S, Turman C, Ma J, Hunter DJ, Riboli E, Siddiq A, Canzian F, Kolonel LN, Le Marchand L, Hoover RN, Machiela MJ, Kraft P, Freedman M, Wiklund F, Chanock S, Henderson BE, Easton DF, Haiman CA, Eeles RA, Conti DV, Kote-Jarai Z
(A1 Refereed original research article in a scientific journal)
- Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia (2018) Mucci L., West C., Koutros S., Cancel-Tassin G., Maehle L., Sorensen K., Travis R., Neal D., Batra J., Tangen C., Gronberg H., Clements J., Albanes D., Schleutker J., Wolk A., Weinstein S., Penney K., Park J., Stanford J., Cybulski C., Nordestgaard B., Brenner H., Maier C., Kim J., Hamilton R., Ingles S., Rosenstein B., Lu Y., Giles G., Kibel A., Vega A., Kogevinas M., Dominguez M., Townsend P., Claessens F., Usmani N., Menegaux F., Roobol M., De Ruyck K., Neuhausen S., Teixeira M., John E., Kaneva R., Lessel D., Newcomb L., Razack A., Vijayakrishnan J., Kumar R., Law P., Harrison C., Allan J., Broderick P., Studd J., Holroyd A., Kinnersley B., Sheridan E., Kinsey S., Irving J., Thompson P., Vora A., Moorman A., Rachakonda S., Roman E., Pharaoh P., Dunning A., Jöckel K., Easton D., Nöthen M., Heilmann-Heimbach S., Koehler R., Hoffmann P., Pashayan N., Greaves M., Kote-Jarai Z., Muir K., Swerdlow A., Eeles R., Peto J., Canzian F., Haiman C., Henderson B., Houlston R., Hemminki K., Stanulla M., Schrappe M., Bartram C., Zimmerman M., Stevens V., Chanock S., Wiklund F., Conti D., Berndt S., Olama A., Schumacher F., Benlloch S.
(A1 Refereed original research article in a scientific journal)
- Germline variants in IL4, MGMT and AKT1 are associated with prostate cancer-specific mortality: An analysis of 12,082 prostate cancer cases (2018)
- Prostate Cancer and Prostatic Diseases
L. M. FitzGerald, S. Zhao, A. Leonardson, M. S. Geybels, S. Kolb, D. W. Lin, J. L. Wright, R. Eeles, Z. Kote-Jarai, K. Govindasami, G. G. Giles, M. C. Southey, J. Schleutker, T. L. Tammela, C. Sipeky, K. L. Penney, M. J. Stampfer, H. Gronberg, F. Wiklund, P. Stattin, J. Hugosson, D. M. Karyadi, E. A. Ostrander, Z. Feng, J. L. Stanford
(A1 Refereed original research article in a scientific journal)
- Germline variation at 8q24 and prostate cancer risk in men of European ancestry (2018) Matejcic M, Saunders EJ, Dadaev T, Brook MN, Wang K, Sheng X, Al Olama AA, Schumacher FR, Ingles SA, Govindasami K, Benlloch S, Berndt SI, Albanes D, Koutros S, Muir K, Stevens VL, Gapstur SM, Tangen CM, Batra J, Clements J, Gronberg H, Pashayan N, Schleutker J, Wolk A, West C, Mucci L, Kraft P, Cancel-Tassin G, Sorensen KD, Maehle L, Grindedal EM, Strom SS, Neal DE, Hamdy FC, Donovan JL, Travis RC, Hamilton RJ, Rosenstein B, Lu YJ, Giles GG, Kibel AS, Vega A, Bensen JT, Kogevinas M, Penney KL, Park JY, Stanford JL, Cybulski C, Nordestgaard BG, Brenner H, Maier C, Kim J, Teixeira MR, Neuhausen SL, De Ruyck K, Razack A, Newcomb LF, Lessel D, Kaneva R, Usmani N, Claessens F, Townsend PA, Dominguez MG, Roobol MJ, Menegaux F, Khaw KT, Cannon-Albright LA, Pandha H, Thibodeau SN, Schaid DJ, Wiklund F, Chanock SJ, Easton DF, Eeles RA, Kote-Jarai Z, Conti DV, Haiman CA
(A1 Refereed original research article in a scientific journal)
- Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma (2018) Went M, Sud A, Forsti A, Halvarsson BM, Weinhold N, Kimber S, van Duin M, Thorleifsson G, Holroydl A, Johnson DC, Li N, Orlando G, Law PJ, Ali M, Chen BW, Mitchell JS, Gudbjartsson DF, Kuiper R, Stephens OW, Bertsch U, Broderick P, Campo C, Bandapalli OR, Einsele H, Gregory WA, Gullberg U, Hillengass J, Hoffmann P, Jackson GH, Jockel KH, Johnsson E, Kristinsson SY, Mellqvist UH, Nahi H, Easton D, Pharoah P, Dunning A, Peto J, Canzian F, Swerdlow A, Eeles RA, Kote-Jarai Z, Muir K, Pashayan N, Nickel J, Nothen MM, Rafnar T, Ross FM, Filho MID, Thomsen H, Turesson I, Vangsted A, Andersen NF, Waage A, Walker BA, Wihlborg AK, Broyl A, Davies FE, Thorsteinsdottir U, Langer C, Hansson M, Goldschmidt H, Kaiser M, Sonneveld P, Stefansson K, Morgans GJ, Hemminki K, Nilsson B, Houlston RS, Nilsson B, Houlston RS; Group Author(s): PRACTICAL Consortium
(A1 Refereed original research article in a scientific journal)
- Large-scale transcriptome-wide association study identifies new prostate cancer risk regions (2018) Mancuso N, Gayther S, Gusev A, Zheng W, Penney KL, Kote-Jarai Z, Eeles R, Freedman M, Haiman C, Pasaniuc B; The PRACTICAL consortium
(A1 Refereed original research article in a scientific journal)
- Polygenic hazard score to guide screening for aggressive - prostate cancer: development and validation in large scale - cohorts (2018) Tyler M Seibert, Chun Chieh Fan, Yunpeng Wang, Verena Zuber, Roshan Karunamuni,
J Kellogg Parsons, Rosalind A Eeles, Douglas F Easton, ZSofia Kote-Jarai, Ali Amin Al Olama,
Sara Benlloch Garcia, Kenneth Muir, Henrik Grönberg, Fredrik Wiklund, Markus Aly,
Johanna Schleutker, Csilla Sipeky, Teuvo LJ Tammela, Børge G Nordestgaard,
Sune F Nielsen, Maren Weischer, Rasmus Bisbjerg, M Andreas Røder, Peter Iversen,
Tim J Key, Ruth C Travis, David E Neal, Jenny L Donovan, Freddie C Hamdy,
Paul Pharoah, Nora Pashayan, Kay-Tee Khaw, Christiane Maier, Walther Vogel,
Manuel Luedeke, Kathleen Herkommer, Adam S Kibel, Cezary Cybulski,
Dominika Wokolorczyk, Wojciech Kluzniak, Lisa Cannon-Albright, Hermann Brenner,
Katarina Cuk, Kai-Uwe Saum, Jong Y Park, Thomas A Sellers, Chavdar Slavov,
Radka Kaneva, Vanio Mitev, Jyotsna Batra, Judith A Clements, Amanda Spurdle,
Manuel R Teixeira, Paula Paulo, Sofia Maia, Hardev Pandha, Agnieszka Michael,
Andrzej Kierzek, David S Karow, Ian G Mills, Ole A Andreassen, Anders M Dale,
The PRACTICAL Consortium
(A1 Refereed original research article in a scientific journal)
- Synergistic Interaction of HOXB13 and CIP2A Predisposes to Aggressive Prostate Cancer (2018) Csilla Sipeky, Ping Gao, Qin Zhang, Liang Wang, Otto Ettala, Kirsi M. Talala, Teuvo L.J. Tammela, Anssi Auvinen, Fredrik Wiklund, Gong-Hong Wei, Johanna Schleutker
(A1 Refereed original research article in a scientific journal)
- A genetic variant near GATA3 implicated in inherited susceptibility and etiology of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS) (2017) Na R, Helfand BT, Chen HT, Conran CA, Crawford SE, Hayward SW, Tammela TLJ, Hoffman-Bolton J, Zheng SQL, Walsh PC, Schleutker J, Platz EA, Isaacs WB, Xu JF
(A1 Refereed original research article in a scientific journal)
- Alcohol consumption and prostate cancer incidence and progression: A Mendelian randomisation study (2017)
- International Journal of Cancer
Brunner C, Davies NM, Martin RM, Eeles R, Easton D, Kote-Jarai Z, Al Olama AA, Benlloch S, Muir K, Giles G, Wiklund F, Gronberg H, Haiman CA, Schleutker J, Nordestgaard BG, Travis RC, Neal D, Donovan J, Hamdy FC, Pashayan N, Khaw KT, Stanford JL, Blot WJ, Thibodeau S, Maier C, Kibel AS, Cybulski C, Cannon-Albright L, Brenner H, Park J, Kaneva R, Batra J, Teixeira MR, Pandha H, Zuccolo L
(A1 Refereed original research article in a scientific journal)
- Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer (2017) Hilker C., Windebank S., Meyer J., Zuber V., Mills I., Andreassen O., Witoelar A., Bettella F., Kote-Jarai Z., Easton D., Eeles R., Urbanucci A., Giles G., Muir K., Benlloch S., Al Olama A., Weischer M., Travis R., Neal D., Pharoah P., Wiklund F., Gronberg H., Haiman C., Schleutker J., Maier C., Kibel A., Cybulski C., Cannon-Albright L., Khaw K., Stanford J., Blot W., Thibodeau S., Pandha H., Teixeira M., Humphreys M., Chenevix-Trench G., Park J., Brenner H., Batra J., Kaneva R., Houlston R., Rosenberger A., Landi M., Caporaso N., Han Y., Hung R., Bickeböller H., Brennan P., Easton D., Michailidou K., Christiani D., Amos C., Wu X., Ye Y., Heinrich J., Risch A., Offit K., Dennis J., McGuffog L., Couch F., Berchuck A., Antoniou A., Bolla M., Wang Q., Tessier D., Simard J., Gonzalez-Neira A., Benitez J., Luccarini C., Dicks E., Lee A., Dunning A., Cunningham J., Nordestgaard B., Nielsen S., Bojesen S., Robidoux F., LaBoissière S., Vincent D., Bacot F.
(A1 Refereed original research article in a scientific journal)
- Case-control analysis of truncating mutations in DNA damage response genes connects TEX15 and FANCD2 with hereditary breast cancer susceptibility (2017) Tuomo Mantere, Anna Tervasmäki, Anna Nurmi, Katrin Rapakko, Saila Kauppila, Jiangbo Tang, Johanna Schleutker, Anne Kallioniemi, Jaana M. Hartikainen, Arto Mannermaa, Pentti Nieminen, Riitta Hanhisalo, Sini Lehto, Maija Suvanto, Mervi Grip, Arja Jukkola-Vuorinen, Maria Tengström, Päivi Auvinen, Anders Kvist, Åke Borg, Carl Blomqvist, Kristiina Aittomäki, Roger A. Greenberg, Robert Winqvist, Heli Nevanlinna, Katri Pylkäs
(A1 Refereed original research article in a scientific journal)
