Johanna Schleutker
PhD, Professor of Medical Genetics
Areas of expertise
Cancer genetics; hereditary cancer; genomics; human genetics
Biography
Johanna Schleutker got her PhD in 1995 in University of Turku, Faculty of Medicine.The topic of her doctoral thesis was "Linkage disequilibrium is Salla disease; positioning of the sialic acid transport defect". She then moved to University of Tampere, and did her post doc in 1996-1998 in the Cancer Genetics research group of Professor Olli Kallioniemi. Her career continued in the US where she spent the years of 1999-2000 working as a research associate at the National Human Genome Research Institute, National Institutes of Health, Bethesda, MD. During the NIH years, she studied genetics of familial prostate cancer in the group of Dr. Jeffrey M.Trent. After her return to Finland, Schleutker started her own research group in 2001 at the Insitute of Medical Technology, University of Tampere, and has ever since focused her studies on genetics and genetic susceptibility of prostate and breast cancer. Schleutker got a professorship in University of Tampere in 2008. In 2011 she started as a professor of medical genetics in University of Turku.
Research
The Schleutker group "Genetic Predisposition to Cancer" is studying both breast and prostate cancer genetics, the main emphasis being on prostate cancer. Of all cancers, prostate cancer (PrCa) has been reported as one of the most heritable diseases: genetic factors have been estimated to account for 57% of the risk. The goal is to identify and characterize predisposing genes and variants, especially those affecting aggressive outcome, including treatment responses to therapies. Further, the aim is to develop tools for prognostic purposes, i.e. prognostic biomarkers. The group has identified many significant genomic risk regions, candidate genes and variants, which have been then further profiled and characterized by functional studies. The group has produced (by 2021) 12 PhD degrees and published over 190 original, peer-reviewed articles in international journals.
Teaching
Genetics, cancer genetics, hereditary cancer, genomics, molecular biology.
Publications
- Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells (2020) Erik L. Bao, Satish K. Nandakumar, Xiaotian Liao, Alexander G. Bick, Juha Karjalainen, Marcin Tabaka, Olga I. Gan, Aki S. Havulinna, Tuomo T. J. Kiiskinen, Caleb A. Lareau, Aitzkoa L. de Lapuente Portilla, Bo Li, Connor Emdin, Veryan Codd, Christopher P. Nelson, Christopher J. Walker, Claire Churchhouse, Albert de la Chapelle, Daryl E. Klein, Björn Nilsson, Peter W. F. Wilson, Kelly Cho, Saiju Pyarajan, J. Michael Gaziano, Nilesh J. Samani, Aviv Regev, Aarno Palotie, Benjamin M. Neale, John E. Dick, Pradeep Natarajan, Christopher J. O’Donnell, Mark J. Daly, Michael Milyavsky, Sekar Kathiresan, Vijay G. Sankaran; FinnGen; 23andMe Research Team
(A1 Refereed original research article in a scientific journal)
- Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers (2020) Mars Nina, Koskela Jukka T., Ripatti Pietari, Kiiskinen Tuomo T. J., Havulinna Aki S., Lindbohm Joni V., Ahola-Olli Ari, Kurki Mitja, Karjalainen Juha, Palta Priit, Neale Benjamin M., Daly Mark, Salomaa Veikko, Palotie Aarno, Widén Elisabeth, Ripatti Samuli; FinnGen
(A1 Refereed original research article in a scientific journal)
- Polygenic Hyperlipidemias and Coronary Artery Disease Risk (2020)
- Circulation: Genomic and Precision Medicine
Ripatti P, Ramo JT, Mars NJ, Fu Y, Lin JK, Soderlund S, Benner C, Surakka I, Kiiskinen T, Havulinna AS, Palta P, Freimer NB, Widen E, Salomaa V, Tukiainen T, Pirinen M, Palotie A, Taskinen MR, Ripatti S; and on behalf of FinnGen
(A1 Refereed original research article in a scientific journal)
- Prostate cancer risk prediction using a polygenic risk score (2020) Csilla Sipeky, Kirsi M. Talala, Teuvo L. J. Tammela, Kimmo Taari, Anssi Auvinen & Johanna Schleutker
(A1 Refereed original research article in a scientific journal)
- Rare protein-altering variants in ANGPTL7 lower intraocular pressure and protect against glaucoma (2020) Tanigawa Yosuke, Wainberg Michael, Karjalainen Juha, Kiiskinen Tuomo, Venkataraman Guhan, Lemmelä Susanna, Turunen Joni A, Graham Robert R, Havulinna Aki S, Perola Markus, Palotie Aarno, Daly Mark J, Rivas Manuel A; FinnGen
(A1 Refereed original research article in a scientific journal)
- ShAn: An easy-to-use tool for interactive and integrated variant annotation (2020) Rathinakannan VS, Schukov HP, Heron S, Schleutker J, Sipeky C
(A1 Refereed original research article in a scientific journal)
- The CHEK2 Variant C.349A>G Is Associated with Prostate Cancer Risk and Carriers Share a Common Ancestor (2020) Brandao A, Paulo P, Maia S, Pinheiro M, Peixoto A, Cardoso M, Silva MP, Santos C, Eeles RA, Kote-Jarai Z, Muir K, Schleutker J, Wang Y, Pashayan N, Batra J, Gronberg H, Neal DE, Nordestgaard BG, Tangen CM, Southey MC, Wolk A, Albanes D, Haiman CA, Travis RC, Stanford JL, Mucci LA, West CML, Nielsen SF, Kibel AS, Cussenot O, Berndt SI, Koutros S, Sorensen KD, Cybulski C, Grindedal EM, Park JY, Ingles SA, Maier C, Hamilton RJ, Rosenstein BS, Vega A, Kogevinas M, Wiklund F, Penney KL, Brenner H, John EM, Kaneva R, Logothetis CJ, Neuhausen SL, De Ruyck K, Razack A, Newcomb LF, Lessel D, Usmani N, Claessens F, Gago-Dominguez M, Townsend PA, Roobol MJ, Teixeira MR; Profile Study Steering Comm; PRACTICAL Consortium
(A1 Refereed original research article in a scientific journal)
- The effect of sample size on polygenic hazard models for prostate cancer (2020)
- European Journal of Human Genetics
Karunamuni RA, Huynh-Le MP, Fan CC, Eeles RA, Easton DF, Kote-Jarai Z, Al Olama AA, Garcia SB, Muir K, Gronberg H, Wiklund F, Aly M, Schleutker J, Sipeky C, Tammela TLJ, Nordestgaard BG, Key TJ, Travis RC, Neal DE, Donovan JL, Hamdy FC, Pharoah P, Pashayan N, Khaw KT, Thibodeau SN, McDonnell SK, Schaid DJ, Maier C, Vogel W, Luedeke M, Herkommer K, Kibel AS, Cybulski C, Wokolorczyk D, Kluzniak W, Cannon-Albright L, Brenner H, Ben Schottker, Holleczek B, Park JY, Sellers TA, Lin HY, Slavov C, Kaneva R, Mitev V, Batra J, Clements JA, Spurdle A, Teixeira MR, Paulo P, Maia S, Pandha H, Michael A, Mills IG, Andreassen OA, Dale AM, Seibert TM, Seibert TM; & The PRACTICAL Consortium
(A1 Refereed original research article in a scientific journal)
- The interactome of the prostate-specific protein Anoctamin 7 (2020) Elina Kaikkonen, Aliisa Takala, Juha-Pekka Pursiheimo, Gudrun Wahlström, Johanna Schleutker
(A1 Refereed original research article in a scientific journal)
- The role of polygenic risk and susceptibility genes in breast cancer over the course of life (2020) Mars N, Widen E, Kerminen S, Meretoja T, Pirinen M, Parolo PD, Palta P; FinnGen, Havulinna A, Palotie A, Kaprio J, Joensuu H, Daly M, Ripatti S
(A1 Refereed original research article in a scientific journal)
- Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan (2020) Sakaue S, Kanai M, Karjalainen J, Akiyama M, Kurki M, Matoba N, Takahashi A, Hirata M, Kubo M, Matsuda K, Murakami Y, Daly MJ, Kamatani Y, Okada Y
(A1 Refereed original research article in a scientific journal)
- Whole-exome sequencing of Finnish patients with vascular cognitive impairment (2020)
- European Journal of Human Genetics
Saana Mönkäre, Liina Kuuluvainen, Celia Kun-Rodrigues, Susana Carmona, Johanna Schleutker, Jose Bras, Minna Pöyhönen, Rita Guerreiro, Liisa Myllykangas
(A1 Refereed original research article in a scientific journal)
- ANO7 rs77559646 Is Associated With First-line Docetaxel Treatment Response in Metastatic Castration-resistant Prostate Cancer (2019) Kaikkonen E, Ettala O, Nikulainen I, Taimen P, Lehtinen I, Bostrom PJ, Kellokumpu-Lehtinen PL, Schleutker J
(A1 Refereed original research article in a scientific journal)
- Association analyses identify 31 new risk loci for colorectal cancer susceptibility (2019) Law PJ, Timofeeva M, Fernandez-Rozadilla C, Timofeeva A, Broderick P, Studd J, Fernandez-Tajes J, Farrington S, Svinti V, Palles C, Orlando G, Sud A, Holroyd A, Penegar S, Theodoratou E, Vaughan-Shaw P, Campbell H, Zgaga L, Hayward C, Campbell A, Harris S, Deary IJ, Starr O, Gatcombe L, Pinna M, Briggs S, Martin L, Jaeger E, Sharma-Oates A, East J, Leedham S, Arnold R, Johnstone E, Wang H, Kerr D, Kerr R, Maughan T, Kaplan R, Al-Tassan N, Palin K, Hanninen UA, Cajuso T, Tanskanen T, Kondelin J, Kaasinen E, Sarin AP, Eriksson JG, Rissanen H, Knekt P, Pukkala E, Jousilahti P, Salomaa V, Ripatti S, Palotie A, Renkonen-Sinisalo L, Lepisto A, Bohm J, Mecklin JP, Buchanan DD, Win AK, Hopper J, Jenkins ME, Lindor NM, Newcomb PA, Gallinger S, Duggan D, Casey G, Hoffmann P, Nothen MM, Jockel KH, Easton DF, Pharoah PDP, Peto J, Canzian F, Swerdlow A, Eeles RA, Kote-Jarai Z, Muir K, Pashayan N, Harkin A, Allan K, McQueen J, Paul J, Iveson T, Saunders M, Butterbach K, Chang-Claude J, Hoffmeister M, Brenner H, Kirac I, Matosevic P, Hofer P, Brezina S, Gsur A, Cheadle JP, Aaltonen LA, Tomlinson I, Houlston RS, Dunlop MG, Henderson BE, Haiman CA, Schumacher FR, Al Olama AA, Benlloch S, Berndt SI, Conti DV, Wiklund F, Chanock S, Gapstur S, Stevens VL, Tangen CM, Batra J, Clements J, Gronberg H, Schleutker J, Albanes D, Wolk A, West C, Mucci L, Cancel-Tassin G, Koutros S, Sorensen KD, Grindeda EM, Neal DE, Hamdy FC, Donovan JL, Travis RC, Hamilton RJ, Ingles SA, Rosenstein BS, Lu YJ, Giles GG, Kibel AS, Vega A, Kogevinas M, Penney KL, Park JY, Stanford JL, Cybulski C, Nordestgaard BG, Maier C, Kim J, John EM, Teixeira MR, Neuhausen SL, De Ruyck K, Razack A, Newcomb LF, Gamulin M, Kaneva R, Usmani N, Claessens F, Townsend PA, Gago-Dominguez M, Roobol MJ, Menegaux F, Khaw KT, Cannon-Albright L, Pandha H, Thibodeau SN
(A1 Refereed original research article in a scientific journal)
- Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study (2019)
- Cancer Epidemiology, Biomarkers and Prevention
Charleen D. Adams, Rebecca Richmond, Diana L. Santos Ferreira, Wes Spiller, Vanessa Tan, Jie Zheng, Peter Würtz, Jenny Donovan, Freddie Hamdy, David Neal, J. Athene Lane, George Davey Smith, Caroline Relton, Rosalind A. Eeles, Christopher A. Haiman, ZSofia Kote-Jarai, Fredrick R. Schumacher, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Sonja I. Berndt, David V. Conti, Fredrik Wiklund, Stephen J. Chanock, Susan Gapstur, Victoria L. Stevens, Catherine M. Tangen, Jyotsna Batra, Judith A. Clements, Henrik Gronberg, Nora Pashayan, Johanna Schleutker, Demetrius Albanes, Alicja Wolk, Catharine M.L. West, Lorelei A. Mucci, Géraldine Cancel-Tassin, Stella Koutros, Karina Dalsgaard Sorensen, Lovise Maehle, Ruth C. Travis, Robert J. Hamilton, Sue Ann Ingles, Barry S. Rosenstein, Yong-Jie Lu, Graham G. Giles, Adam S. Kibel, Ana Vega, Manolis Kogevinas, Kathryn L. Penney, Jong Y. Park, Janet L. Stanford, Cezary Cybulski, Børge G. Nordestgaard, Hermann Brenner, Christiane Maier, Jeri Kim, Esther M. John, Manuel R. Teixeira, Susan L. Neuhausen, Kim De Ruyck, Azad Razack, Lisa F. Newcomb, Davor Lessel, Radka P. Kaneva, Nawaid Usmani, Frank Claessens, Paul A. Townsend, Manuela Gago Dominguez, Monique J. Roobol, Florence Menegaux, Kay-Tee Khaw, Lisa A. Cannon-Albright, Hardev Pandha, Stephen N. Thibodeau; on behalf of the PRACTICAL consortium, Richard M. Martin
(A1 Refereed original research article in a scientific journal)
- Genetic architecture of human plasma lipidome and its link to cardiovascular disease (2019) Tabassum R, Ramo JT, Ripatti P, Koskela JT, Kurki M, Karjalainen J, Palta P, Hassan S, Nunez-Fontarnau J, Kiiskinen TTJ, Soderlund S, Matikainen N, Gerl MJ, Surma MA, Klose C, Stitziel NO, Laivuori H, Havulinna AS, Service SK, Salomaa V, Pirinen M, Jauhiainen M, Daly MJ, Freimer NB, Palotie A, Taskinen MR, Simons K, Ripatti S, Jalanko A, Kaprio J, Donner K, Kaunisto M, Mars N, Dada A, Shcherban A, Ganna A, Lehisto A, Kilpelainen E, Brein G, Awaisa G, Harju J, Parr K, Parolo PD, Kajanne R, Lemmela S, Sipila TP, Sipila T, Lyhs U, Llorens V, Niiranen T, Kristiansson K, Mannikko L, Jimenez MG, Perola M, Wong R, Kilpi T, Hiekkalinna T, Jarvensivu E, Kaiharju E, Mattsson H, Laukkanen M, Laiho P, Lahteenmaki S, Sistonen T, Soini S, Ziemann A, Lehtonen A, Lertratanakul A, Georgantas B, Riley-Gillis B, Quarless D, Rahimov F, Heap G, Jacob H, Waring J, Davis JW, Smaoui N, Popovic R, Esmaeeli S, Waring J, Matakidou A, Challis B, Close D, Petrovski S, Karlsson A, Schleutker J, Pulkki K, Virolainen P, Kallio L, Mannermaa A, Heikkinen S, Kosma VM, Chen CY, Runz H, Liu J, Bronson P, John S, Landenpera S, Eaton S, Zhou W, Hendolin M, Tuovila O, Pakkanen R, Maranville J, Usiskin K, Hochfeld M, Plenge R, Yang R, Biswas S, Greenberg S, Laakkonen E, Kononen J, Paloneva J, Kujala U, Kuopio T, Laukkanen J, Kangasniemi E, Savinainen K, Laaksonen R, Arvas M, Ritari J, Partanen J, Hyvarinen K, Wahlfors T, Peterson A, Oh D, Chang D, Teng E, Strauss E, Kerchner G, Chen H, Chen H, Schutzman J, Michon J, Hunkapiller J, McCarthy M, Bowers N, Lu T, Bhangale T, Pulford D, Waterworth D, Kulkarni D, Xu FL, Betts J, Gordillo JE, Hoffman J, Auro K, McCarthy L, Ghosh S, Ehm M, Pitkanen K, Makela T, Loukola A, Joensuu H, Sinisalo J, Eklund K, Aaltonen L, Farkkila M, Carpen O, Kauppi P, Tienari P, Ollila T, Tuomi T, Meretoja T, Pitkaranta A, Turunen J, Hannula-Jouppi K, Pikkarainen S, Seitsonen S, Koskinen M, Palomaki A, Rinne J, Metsarinne K, Elenius K, Pirila L, Koulu L, Voutilainen M, Juonala M, Peltonen S, Aaltonen V, Loboda A, Podgornaia A, Chhibber A, Chu A, Fox C, Diogo D, Holzinger E, Eicher J, Gormley P, Mehta V, Wang XL, Kettunen J, Pylkas K, Kalaoja M, Karjalainen M, Hinttala R, Kaarteenaho R, Vainio S, Mantere T, Remes A, Huhtakangas J, Junttila J, Tasanen K, Huilaja L, Luodonpaa M, Hautala N, Karihtala P, Kauppila S, Harju T, Blomster T, Soininen H, Harvima I, Pihlajamaki J, Kaarniranta K, Pelkonen M, Laakso M, Hiltunen M, Kiviniemi M, Kaipiainen-Seppanen O, Auvinen P, Kalviainen R, Julkunen V, Malarstig A, Hedman A, Marshal C, Whelan C, Lehtonen H, Parkkinen J, Linden K, Kalpala K, Miller M, Bing N, McDonough S, Chen X, Hu XL, Wu Y, Auranen A, Jussila A, Uusitalo-Jarvinen H, Kankaanranta H, Uusitalo H, Peltola J, Kahonen M, Isomaki P, Laitinen T, Salmi T, Muslin A, Wang C, Chatelain C, Xu E, Auge F, Call K, Klinger K, Crohns M, Gossel M, Palin K, Rivas M, Siirtola H, Tabuenca JG
(A1 Refereed original research article in a scientific journal)
- Identification of Novel Susceptibility Loci and Genes for Prostate Cancer Risk: A Transcriptome-Wide Association Study in over 140,000 European Descendants (2019) Lang Wu, Jifeng Wang, Qiuyin Cai, Taylor B. Cavazos, Nima C. Emami, Jirong Long, Xiao-Ou Shu, Yingchang Lu, Xingyi Guo, Joshua A. Bauer, Bogdan Pasaniuc, Kathryn L. Penney, Matthew L. Freedman; and the PRACTICAL, CRUK; BPC3; CAPS; PEGASUS Consortia; Zsofia Kote-Jarai, John S. Witte, Christopher A. Haiman, Rosalind A. Eeles, Wei Zheng
(A1 Refereed original research article in a scientific journal)
- Keskustelu on tärkeää tiedon määrän kasvaessa (2019) Kankuri-Tammilehto Minna, Vihinen Pia, Schleutker Johanna
(D1 Article in a professional journal)
- Oligogenic basis of sporadic ALS The example of SOD1 p.Ala90Val mutation (2019) Liina Kuuluvainen, Karri Kaivola, Saana Mönkäre, Hannu Laaksovirta, Manu Jokela, Bjarne Udd, Miko Valori, Petra Pasanen, Anders Paetau, Bryan J. Traynor, David J. Stone, Johanna Schleutker, Minna Pöyhönen, Pentti J. Tienari, Liisa Myllykangas
(A1 Refereed original research article in a scientific journal)
- Recurrent moderate-risk mutations in Finnish breast and ovarian cancer patients (2019)
- International Journal of Cancer
Anna Nurmi, Taru A. Muranen, Liisa M. Pelttari, Johanna I. Kiiski, Tuomas Heikkinen, Sini Lehto, Anne Kallioniemi, Johanna Schleutker, Ralf Bützow, Carl Blomqvist, Kristiina Aittomäki, Heli Nevanlinna
(A1 Refereed original research article in a scientific journal)
