Johanna Schleutker
PhD, Professor of Medical Genetics
Asiantuntijuusalueet
Cancer genetics; hereditary cancer; genomics; human genetics
Biografia
Johanna Schleutker got her PhD in 1995 in University of Turku, Faculty of Medicine.The topic of her doctoral thesis was "Linkage disequilibrium is Salla disease; positioning of the sialic acid transport defect". She then moved to University of Tampere, and did her post doc in 1996-1998 in the Cancer Genetics research group of Professor Olli Kallioniemi. Her career continued in the US where she spent the years of 1999-2000 working as a research associate at the National Human Genome Research Institute, National Institutes of Health, Bethesda, MD. During the NIH years, she studied genetics of familial prostate cancer in the group of Dr. Jeffrey M.Trent. After her return to Finland, Schleutker started her own research group in 2001 at the Insitute of Medical Technology, University of Tampere, and has ever since focused her studies on genetics and genetic susceptibility of prostate and breast cancer. Schleutker got a professorship in University of Tampere in 2008. In 2011 she started as a professor of medical genetics in University of Turku.
Tutkimus
The Schleutker group "Genetic Predisposition to Cancer" is studying both breast and prostate cancer genetics, the main emphasis being on prostate cancer. Of all cancers, prostate cancer (PrCa) has been reported as one of the most heritable diseases: genetic factors have been estimated to account for 57% of the risk. The goal is to identify and characterize predisposing genes and variants, especially those affecting aggressive outcome, including treatment responses to therapies. Further, the aim is to develop tools for prognostic purposes, i.e. prognostic biomarkers. The group has identified many significant genomic risk regions, candidate genes and variants, which have been then further profiled and characterized by functional studies. The group has produced (by 2021) 12 PhD degrees and published over 190 original, peer-reviewed articles in international journals.
Opetus
Genetics, cancer genetics, hereditary cancer, genomics, molecular biology.
Julkaisut
- Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer (2017) Hilker C., Windebank S., Meyer J., Zuber V., Mills I., Andreassen O., Witoelar A., Bettella F., Kote-Jarai Z., Easton D., Eeles R., Urbanucci A., Giles G., Muir K., Benlloch S., Al Olama A., Weischer M., Travis R., Neal D., Pharoah P., Wiklund F., Gronberg H., Haiman C., Schleutker J., Maier C., Kibel A., Cybulski C., Cannon-Albright L., Khaw K., Stanford J., Blot W., Thibodeau S., Pandha H., Teixeira M., Humphreys M., Chenevix-Trench G., Park J., Brenner H., Batra J., Kaneva R., Houlston R., Rosenberger A., Landi M., Caporaso N., Han Y., Hung R., Bickeböller H., Brennan P., Easton D., Michailidou K., Christiani D., Amos C., Wu X., Ye Y., Heinrich J., Risch A., Offit K., Dennis J., McGuffog L., Couch F., Berchuck A., Antoniou A., Bolla M., Wang Q., Tessier D., Simard J., Gonzalez-Neira A., Benitez J., Luccarini C., Dicks E., Lee A., Dunning A., Cunningham J., Nordestgaard B., Nielsen S., Bojesen S., Robidoux F., LaBoissière S., Vincent D., Bacot F.
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- Case-control analysis of truncating mutations in DNA damage response genes connects TEX15 and FANCD2 with hereditary breast cancer susceptibility (2017) Tuomo Mantere, Anna Tervasmäki, Anna Nurmi, Katrin Rapakko, Saila Kauppila, Jiangbo Tang, Johanna Schleutker, Anne Kallioniemi, Jaana M. Hartikainen, Arto Mannermaa, Pentti Nieminen, Riitta Hanhisalo, Sini Lehto, Maija Suvanto, Mervi Grip, Arja Jukkola-Vuorinen, Maria Tengström, Päivi Auvinen, Anders Kvist, Åke Borg, Carl Blomqvist, Kristiina Aittomäki, Roger A. Greenberg, Robert Winqvist, Heli Nevanlinna, Katri Pylkäs
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- Circulating vitamin D concentration and risk of seven cancers: Mendelian randomisation study (2017) Dimitrakopoulou VI, Tsilidis KK, Haycock PC, Dimou NL, Al-Dabhani K, Martin RM, Lewis SJ, Gunter MJ, Mondul A, Shui IM, Theodoratou E, Nimptsch K, Lindstrom S, Albanes D, Kuhn T, Key TJ, Travis RC, Vimaleswaran KS, Kraft P, Pierce BL, Schildkraut JM, Schildkraut JM; GECCO Consortium; PRACTICAL Consortium; GAME-ON Network
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- FANCM mutation c.5791C > T is a risk factor for triple-negative breast cancer in the Finnish population (2017)
- Breast Cancer Research and Treatment
Kiiski JI, Tervasmaki A, Pelttari LM, Khan S, Mantere T, Pylkas K, Mannermaa A, Tengstrom M, Kvist A, Borg A, Kosma VM, Kallioniemi A, Schleutker J, Butzow R, Blomqvist C, Aittomaki K, Winqvist R, Nevanlinna H
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- Geneettinen alttius syövälle (2017) Kankuri-Tammilehto Minna, Schleutker Johanna
(A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä)
- Genetic association analysis of the RTK/ERK pathway with aggressive prostate cancer highlights the potential role of CCND2 in disease progression (2017) Chen Y, Zhang Q, Wang QY, Li J, Sipeky C, Xia JH, Gao P, Hu YL, Zhang HY, Yang XB, Chen HT, Jiang YH, Yang YH, Yao ZT, Chen YC, Gao Y, Tan AH, Liao M, Schleutker J, Xu JF, Sun YH, Wei GH, Mo ZN, Mo ZN
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility (2017) Teixeira M., John E., De Ruyck K., Neuhausen S., Newcomb L., Razack A., Kaneva R., Lessel D., Park J., Penney K., Cybulski C., Stanford J., Brenner H., Nordestgaard B., Kim J., Maier C., Jöckel K., Strandmann E., Lightfoot T., Kane E., Roman E., Lake A., Montgomery D., Jarrett R., Usmani N., Claessens F., Townsend P., Dominguez M., Roobol M., Menegaux F., Hoffmann P., Nöthen M., Hemminki K., Orr N., Engert A., Swerdlow A., Houlston R., Law P., Försti A., Filho M., Holroyd A., Sud A., Thomsen H., Easton D., Cooke R., Dunning A., Pharoah P., Orlando G., Broderick P., Wright L., Lenive O., Pashayan N., Muir K., Haiman C., Henderson B., Canzian F., Peto J., Kote-Jarai Z., Eeles R., Chanock S., Stevens V., Conti D., Wiklund F., Olama A., Berndt S., Benlloch S., Schumacher F., Weinstein S., Wolk A., Schleutker J., Albanes D., Clements J., Gronberg H., Tangen C., Batra J., Travis R., Neal D., Maehle L., Sorensen K., Koutros S., Cancel-Tassin G., Mucci L., West C., Kogevinas M., Vega A., Kibel A., Giles G., Lu Y., Rosenstein B., Ingles S., Hamilton R.
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- Germline EMSY sequence alterations in hereditary breast cancer and ovarian cancer families (2017) Maatta KM, Nurminen R, Kankuri-Tammilehto M, Kallioniemi A, Laasanen SL, Schleutker J
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- gsSKAT: Rapid gene set analysis and multiple testing correction for rare-variant association studies using weighted linear kernels (2017) Larson NB, McDonnell S, Albright LC, Teerlink C, Stanford J, Ostrander EA, Isaacs WB, Xu JF, Cooney KA, Lange E, Schleutker J, Carpten JD, Powell I, Bailey-Wilson JE, Cussenot O, Cancel-Tassin G, Giles GG, MacInnis RJ, Maier C, Whittemore AS, Hsieh CL, Wiklund F, Catolona WJ, Foulkes W, Mandal D, Eeles R, Kote-Jarai Z, Ackerman MJ, Olson TM, Klein CJ, Thibodeau SN, Schaid DJ
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- Height, selected genetic markers and prostate cancer risk: Results from the PRACTICAL consortium (2017)
- British Journal of Cancer
Kedda M., Kerr K., Saunders P., Turner M., Srinivasan S., Heathcote P., Yeadon T., Omara T., Christova S., Popov E., Eckert A., Dikov T., Wood G., Collins A., Alexander K., Malone G., Lose F., Stewart-Brown S., Kote-Jarai Z., Lophatananon A., Hamdy F., Neal D., Garcia S., Olama A., Southey M., Fitzgerald L., Giles G., Donovan J., Aly M., Gronberg H., Pashayan N., Pharoah P., Arndt V., Dieffenbach A., Brenner H., Stanford J., Kaneva R., Mitev V., Batra J., Spurdle A., Park J., Lin H., Sellers T., Slavov C., Schleutker J., Nordestgaard B., Wiklund F., Travis R., Clements J., Easton D., Eeles R., Muir K., Kibel A., Blot W., Cannon-Albright L., Cybulski C., Thibodeau S., Haiman C., Walther V., Maier C., Leongamornlert D., Guy M., Wilkinson R., Sawyer E., Teixeira M., Pandha H., Govindasami K., Cook M., Dadaev T., Cox A., Livni N., Hazel S., Saunders E., Tymrakiewicz M., Morgan A., Fisher C., Hopper J., Karlsson A., Brown P., Pedersen J., Marsden G., Davis M., George A., Lane A., Zachariah B., Stegmaier C., Kolb S., Stattin P., Broms M., Johansson J., Adolfson J., Cavalli-Bjoerkman C., Kachakova D., Mitkova A., Vlahova A., Radlein S., Rincon M., Pow-Sang J., Haley J., Park H.
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
