Mari Vähä-Mäkilä

- Research Coordinator,
Institute of Biomedicine (Faculty of Medicine)

mari.vaha-makila@utu.fi

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Serum APOC1 levels are decreased in young autoantibody positive children who rapidly progress to type 1 diabetes (2023)
- Scientific Reports
Hirvonen M Karoliina, Lietzén Niina, Moulder Robert, Bhosale Santosh D, Koskenniemi Jaakko, Vähä-Mäkilä Mari, Nurmio Mirja , Orešič Matej, Ilonen Jorma, Toppari Jorma, Veijola Riitta, Hyöty Heikki, Lähdesmäki Harri, Knip Mikael, Cheng Lu, Lahesmaa Riitta
Permutation-based significance analysis reduces the type 1 error rate in bisulfite sequencing data analysis of human umbilical cord blood samples (2022)
- Epigenetics
Laajala Essi, Halla-Aho Viivi, Grönroos Toni, Kalim Ubaid Ullah, Vähä-Mäkilä Mari, Nurmio Mirja, Kallionpää Henna, Lietzén Niina, Mykkänen Juha, Rasool Omid, Toppari Jorma, Oresic Matej, Knip Mikael, Lund Riikka, Lahesmaa Riitta, Lähdesmäki Harri
Type 1 Diabetes in Children With Genetic Risk May Be Predicted Very Early With a Blood miRNA (2022)
- Diabetes Care
Suomi Tomi, Kalim Ubaid Ullah, Rasool Omid, Laiho Asta, Kallionpää Henna, Vähä-Mäkilä Mari, Nurmio Mirja, Mykkänen Juha, Härkönen Taina, Hyöty Heikki, Ilonen Jorma, Veijola Riitta, Toppari Jorma, Knip Mikael, Elo Laura L, Lahesmaa Riitta
Umbilical cord blood DNA methylation in children who later develop type 1 diabetes (2022)
- Diabetologia
Laajala Essi, Kalim Ubaid U, Grönroos Toni, Rasool Omid, Halla-aho Viivi, Konki Mikko, Kattelus Roosa, Mykkänen Juha, Nurmio Mirja, Vähä-Mäkilä Mari, Kallionpää Henna, Lietzen Niina, Ghimire Bishwa R, Laiho Asta, Hyöty Heikki, Elo Laura L, Ilonen Jorma, Knip Mikael, Lund Riikka J, Orešič Matej, Veijola Riitta, Lähdesmäki Harri, Toppari Jorma, Lahesmaa Riitta
Distinct Growth Phases in Early Life Associated With the Risk of Type 1 Diabetes: The TEDDY Study (2020)
- Diabetes Care
Liu X, Vehik K, Huang YX, Larsson HE, Toppari J, Ziegler AG, She JX, Rewers M, Hagopian WA, Akolkar B, Krischer JP; and the TEDDY Study Group
Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study (2020)
- Diabetes
Li Q, Parikh H, Butterworth MD, Lernmark A, Hagopian W, Rewers M, She JX, Toppari J, Ziegler AG, Akolkar B, Fiehn O, Fan SL, Krischer JP; and the TEDDY Study Group
Association of gluten intake during the first 5 years of life with incidence of celiac disease autoimmunity and celiac disease among children at increased risk (2019)
- JAMA: Journal of the American Medical Association
Carin Andrén Aronsson, Hye-Seung Lee, Elin M. Hård af Segerstad, Ulla Uusitalo, Jimin Yang, Sibylle Koletzko, Edwin Liu, Kalle Kurppa, Polly J. Bingley, Jorma Toppari, Anette G. Ziegler, Jin-Xiong She, William A. Hagopian, Marian Rewers, Beena Akolkar, Jeffrey P. Krischer, Suvi M. Virtanen, Jill M. Norris, Daniel Agardh; for the TEDDY Study Group
Early probiotic supplementation and the risk of celiac disease in children at genetic risk (2019)
- Nutrients
Ulla Uusitalo , Carin Andren Aronsson , Xiang Liu, Kalle Kurppa, Jimin Yang, Edwin Liu, Jennifer Skidmore, Christiane Winkler, Marian J. Rewers, William A. Hagopian, Jin-Xiong She, Jorma Toppari, Anette-G. Ziegler, Beena Akolkar, Jill M. Norris, Suvi M. Virtanen, Jeffrey P. Krischer, Daniel Agardh; on behalf of the TEDDY Study Group
Maternal Dietary Supplement Use and Development of Islet Autoimmunity in the offspring: the TEDDY Study (2019)
- Pediatric Diabetes
Silvis K, Aronsson CA, Liu X, Uusitalo U, Yang J, Tamura R, Lernmark Å, Rewers M, Hagopian W, She JX, Simell O, Toppari J, Ziegler A, Akolkar B, Krischer J, Norris JM, Virtanen SM, Norris JM; the TEDDY Study Group
Metabolite-related dietary patterns and the development of islet autoimmunity (2019)
- Scientific Reports
Randi K. Johnson, Lauren Vanderlinden, Brian C . DeFelice, Katerina Kechris, Ulla Uusitalo, Oliver Fiehn, Marci Sontag, Tessa Crume, Andreas Beyerlein, Åke Lernmark, Jorma Toppari, Anette-G. Ziegler, Jin-Xiong She, William Hagopian, Marian Rewers, Beena Akolkar, Jeffrey Krischer, Suvi M. Virtanen, Jill M. Norris; & The TEDDY Study Group
Predicting islet cell autoimmunity and type 1 diabetes: An 8-year teddy study progress report (2019)
- Diabetes Care
Jeffrey P. Krischer, Xiang Liu, Kendra Vehik, Beena Akolkar, William A. Hagopian, Marian J. Rewers, Jin-Xiong She, Jorma Toppari, Anette-G. Ziegler, Åke Lernmark; and the TEDDY Study Group
Serum 25-Hydroxyvitamin D Concentrations at Birth in Children Screened for HLA-DQB1 Conferred Risk for Type 1 Diabetes (2019)
- Journal of Clinical Endocrinology and Metabolism
Marjaana Mäkinen, Eliisa Löyttyniemi, Maarit Koskinen, Mari Vähä-Mäkilä, Heli Siljander, Mirja Nurmio, Juha Mykkänen, Suvi M Virtanen, Olli Simell, Heikki Hyöty, Jorma Ilonen, Mikael Knip, Riitta Veijola, Jorma Toppari
The association between stressful life events and respiratory infections during the first 4 years of life: The Environmental Determinants of Diabetes in the Young study (2019)
- Stress and Health
Roth R, Lynch K, Hyöty H, Lönnrot M, Driscoll KA, Johnson SB; the TEDDY Study Group
Time-Resolved Autoantibody Profiling Facilitates Stratification of Preclinical Type 1 Diabetes in Children (2019)
- Diabetes
Endesfelder D, Castell WZ, Bonifacio E, Rewers M, Hagopian WA, She JX, Lernmark Å, Toppari J, Vehik K, Williams AJK, Yu L, Akolkar B, Krischer JP, Ziegler AG, Achenbach P, Achenbach P; for the TEDDY Study Group
Coxsackievirus B1 infections are associated with the initiation of insulin-driven autoimmunity that progresses to type 1 diabetes (2018)
- Diabetologia
Sioofy-Khojine AB, Lehtonen J, Nurminen N, Laitinen OH, Oikarinen S, Huhtala H, Pakkanen O, Ruokoranta T, Hankaniemi MM, Toppari J, Vaha-Makila M, Ilonen J, Veijola R, Knip M, Hyoty H
Early Infant Diet and Islet Autoimmunity in the TEDDY Study (2018)
- Diabetes Care
Ulla Uusitalo, Hye-Seung Lee, Carin Andrén Aronsson, Kendra Vehik, Jimin Yang, Sandra Hummel, Katherine Silvis, Åke Lernmark, Marian Rewers, William Hagopian, Jin-Xiong She, Olli Simell, Jorma Toppari, Anette-G. Ziegler, Beena Akolkar, Jeffrey Krischer, Suvi M. Virtanen, Jill M. Norris; and the TEDDY Study Group
Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity (2018)
- Diabetes
Norris JM, Lee HS, Frederiksen B, Erlund I, Uusitalo U, Yang JM, Lernmark A, Simell O, Toppari J, Rewers M, Ziegler AG, She JX, Onengut-Gumuscu S, Chen WM, Rich SS, Sundvall J, Akolkar B, Krischer J, Virtanen SM, Hagopian W; for the TEDDY Study Group
Serum 25-hydroxyvitamin D concentration at birth in children screened for HLA-DQB1 conferred genetic risk for type 1 diabetes (2018)
- Diabetologia
Mäkinen Marjaana, Löyttyniemi Eliisa, Koskinen Maarit, Vähä-Mäkilä Mari, Siljander Heli, Nurmio Mirja, Mykkänen Juha, Virtanen Suvi M, Simell Olli, Hyöty Heikki, Ilonen Jorma, Knip Mikael, Veijola Riitta, Toppari Jorma
The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update (2018)
- Current Diabetes Reports
Rewers M, Hyöty H, Lernmark Å, Hagopian W, She JX, Schatz D, Ziegler AG, Toppari J, Akolkar B, Krischer J
Genetic and Environmental Interactions Modify the Risk of Diabetes-Related Autoimmunity by 6 Years of Age: The TEDDY Study (2017)
- Diabetes Care
Krischer JP, Lynch KF, Lernmark A, Hagopian WA, Rewers MJ, She JX, Toppari J, Ziegler AG, Akolkar B; and the TEDDY Study Group