Docent Akira Takeda - UTU Research Portal

Akira Takeda
Docent

- Senior Research Fellow,
MediCity (Faculty of Medicine)
- ,
InFLAMES Flagship (Faculty of Medicine)

akitak@utu.fi

+358 29 450 4383

Tykistökatu 6

Turku

ORCID identifier: https://orcid.org/0000-0003-4748-4543

My lab website

Twitter

Areas of expertise

Immunology

Publications

Breast cancer remodels lymphatics in sentinel lymph nodes (2025) Eichin, Dominik; Lehotina, Diana; Kauko, Anni; Uenaka, Maki; Leppänen, Meri; Elima, Kati; Piipponen, Minna; Lönnberg, Tapio; Boström, Pia; Koskivuo, Ilkka; Aittokallio, Tero; Hollmén, Maija; Takeda, Akira; Jalkanen, Sirpa
(A1 Refereed original research article in a scientific journal)
Macrophage sensitivity to bexmarilimab-induced reprogramming is shaped by the tumor microenvironment (2025)
- Journal for Immunotherapy of Cancer
Rannikko, Jenna H.; Turpin, Rita; Boström, Pia; Virtakoivu, Reetta; Harth, Chantal; Takeda, Akira; Tamminen, Anselm; Koskivuo, Ilkka; Hollmén, Maija
(A1 Refereed original research article in a scientific journal)
Endothelial Adhesion Molecules in the Lymphatic Vasculature (2024) Encyclopedia of Immunobiology Takeda, Akira; Jalkanen, Sirpa; Salmi, Marko
(D2 Article in a professional compilation book)
Lymph node lymphatic endothelial cells as multifaceted gatekeepers in the immune system (2023)
- Trends in Immunology
Takeda Akira, Salmi Marko, Jalkanen Sirpa
(A2 Refereed review article in a scientific journal )
Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop (2022)
- Cancer Cell
Hua Yichao, Vella Gerlanda, Rambow Florian, Allen Elizabeth, Antoranz Martinez Asier, Duhamel Marie, Takeda Akira, Jalkanen Sirpa, Junius Steffie, Smeets Ann, Nittner David, Dimmeler Stefanie, Hehlgans Thomas, Liston Adrian, Bosisio Francesca Maria, Floris Giuseppe, Laoui Damya, Hollmén Maija, Lambrechts Diether, Merchiers Pascal, Marine Jean-Christophe, Schlenner Susan, Bergers Gabriele
(A1 Refereed original research article in a scientific journal)
CD73 controls ocular adenosine levels and protects retina from light-induced phototoxicity (2022)
- Cellular and Molecular Life Sciences
Losenkova Karolina, Takeda Akira, Ragauskas Symantas, Cerrada-Gimenez Marc, Vähätupa Maria, Kaja Simon, Paul Marius L., Schmies Constanze C., Rolshoven Georg, Müller Christa E., Sandholm Jouko, Jalkanen Sirpa, Kalesnykas Giedrius, Yegutkin Gennady G.
(A1 Refereed original research article in a scientific journal)
Infection with the enteric pathogen C. rodentium promotes islet-specific autoimmunity by activating a lymphatic route from the gut to pancreatic lymph node (2022)
- Mucosal Immunology
Pöysti Sakari, Toivonen Raine, Takeda Akira, Silojärvi Satu, Yatkin Emrah, Miyasaka Masayuki, Hänninen Arno
(A1 Refereed original research article in a scientific journal)
CD73 contributes to anti-inflammatory properties of afferent lymphatic endothelial cells in humans and mice (2021)
- European Journal of Immunology
Eichin Dominik, Pessia Alberto, Takeda Akira, Laakkonen Joni, Bellmann Lydia, Kankainen Matti, Imhof Beat A, Stoitzner Patrizia, Tang Jing, Salmi Marko, Jalkanen Sirpa
(A1 Refereed original research article in a scientific journal)
Lymphatic Endothelial Cell Activation and Dendritic Cell Transmigration Is Modified by Genetic Deletion of Clever-1 (2021)
- Frontiers in immunology
Tadayon Sina, Dunkel Johannes, Takeda Akira, Eichin Dominik, Virtakoivu Reetta, Elima Kati, Jalkanen Sirpa, Hollmen Maija
(A1 Refereed original research article in a scientific journal)
Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors: Results from a Phase I/II Clinical Trial (2021)
- Clinical Cancer Research
Virtakoivu Reetta, Rannikko Jenna H, Viitala Miro, Vaura Felix, Takeda Akira, Lönnberg Tapio, Koivunen Jussi, Jaakkola Panu, Pasanen Annika, Shetty Shishir, de Jonge Maja JA, Robbrecht Debbie, Ma Yuk Ting, Skyttä Tanja, Minchom Anna, Jalkanen Sirpa, Karvonen Matti K, Mandelin Jami, Bono Petri, Hollmén Maija
(A1 Refereed original research article in a scientific journal)
A Single-Cell Transcriptional Roadmap of the Mouse and Human Lymph Node Lymphatic Vasculature (2020)
- Frontiers in Cardiovascular Medicine
Menglan Xiang, Rubén Adrián Grosso, Akira Takeda, Junliang Pan, Tove Bekkhus, Kevin Brulois, Denis Dermadi, Sofia Nordling, Michael Vanlandewijck, Sirpa Jalkanen, Maria H. Ulvmar, Eugene C. Butcher
(A1 Refereed original research article in a scientific journal)
Single-Cell Transcriptomics of Human Lymph Node Stroma (2020)
- STAR protocols
Takeda Akira, Jalkanen Sirpa
(B1 Non-refereed article in a scientific journal)
Clever-1 contributes to lymphocyte entry into the spleen via the red pulp (2019)
- Science Immunology
Tadayon S, Dunkel J, Takeda A, Halle O, Karikoski M, Gerke H, Rantakari P, Virtakoivu R, Pabst O, Salmi M, Hollmen M, Jalkanen S
(A1 Refereed original research article in a scientific journal)
Single-Cell Survey of Human Lymphatics Unveils Marked Endothelial Cell Heterogeneity and Mechanisms of Homing for Neutrophils (2019)
- Immunity
Takeda A, Hollmén M, Dermadi D, Pan J, Brulois KF, Kaukonen R, Lönnberg T, Boström P, Koskivuo I, Irjala H, Miyasaka M, Salmi M, Butcher EC, Jalkanen S
(A1 Refereed original research article in a scientific journal)
Two-photon imaging of t-cell motility in lymph nodes: In vivo and ex vivo approaches (2018) Intravital Imaging of Dynamic Bone and Immune Systems Akira Takeda, Masayuki Miyasaka, Eiji Umemoto
(A3 Refereed book chapter or chapter in a compilation book)
The molecular cues regulating immune cell trafficking (2017)
- Proceedings of the Japan Academy, Series B Physical and Biological Sciences
Takeda A, Sasaki N, Miyasaka M
(A2 Refereed review article in a scientific journal )
Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility (2016)
- eLife
Takeda A, Kobayashi D, Aoi K, Sasaki N, Sigiura Y, Igarashi H, Tohya K, Inoue A, Hata E, Akahoshi N, Hayasaka H, Kikuta J, Scandella E, Ludewig B, Ishii S, Aoki J, Suematsu M, Ishii M, Takeda K, Jalkanen S, Miyasaka M, Umemoto E
(A1 Refereed original research article in a scientific journal)
Thymocytes in Lyve1-CRE/S1pr1(f/f) Mice accumulate in the Thymus due to cell-intrinsic loss of sphingosine-1-Phosphate receptor expression (2016)
- Frontiers in immunology
Takeda A, Hossain MS, Rantakari P, Simmons S, Sasaki N, Salmi M, Jalkanen S, Miyasaka M
(A1 Refereed original research article in a scientific journal)
Lysophosphatidic acid as a regulator of lymphocyte trafficking in the lymph nodes (2015)
- Translational Cancer Research
Takeda A, Umemoto E, Miyasaka M
(A2 Refereed review article in a scientific journal )