Deepankar Chakroborty
 MSc
deecha@utu.fi +358 29 450 3786 Tykistökatu 6 Turku Office: 4137 ORCID identifier: https://orcid.org/0000-0002-3458-0205  | 
Epidermal Growth Factor Receptor (EGFR), EGFR family; Receptor Tyrosine Kinases; Tyrosine Kinase inhibitors; Cancer; Cancer Biology; Bioinformatics; Functional Genomics; R statistical programming; Therapeutic resistance; High -throughput screen
I am a Doctoral student in the Turku Doctoral Programme of Molecular Medicine. I have a background in biotechnology and bioinformatics. Currently, I am pursuing my PhD under the joint supervision of Prof. Klaus Elenius and Dr. Laura Elo.
Efforts of functional characterization of cancer-associated somatic mutations in oncogenes have been largely incomprehensive because they do not encompass the large majority. I have developed a pipeline to analyze thousands of variants of an oncogenic kinase gene in a single assay, I call iSCREAM (in vitro SCReen for Activating Mutation). We are developing the iSCREAM workflow to preemptively identify and characterize on-target secondary mutations that can cause therapeutic resistance, and then subsequently identify therapies that would potentially work for those resistant mutations.
- DUSP6 inhibition overcomes neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer  (2024)  
- Embo molecular medicine
 
(A1 Refereed original research article in a scientific journal) - Trans-activating mutations of the pseudokinase ERBB3  (2024)  
- Oncogene
 
(A1 Refereed original research article in a scientific journal) - An Unbiased Functional Genetics Screen Identifies Rare Activating ERBB4 Mutations  (2022)  
- Cancer Research Communications
 
(A1 Refereed original research article in a scientific journal) - Novel tools for identification of oncogenic driver mutations  (2022)   Chakroborty Deepankar 
(G5 Article dissertation ) - Identification of Predictive ERBB Mutations by Leveraging Publicly Available Cell Line Databases  (2021)  
- Molecular Cancer Therapeutics
 
(A1 Refereed original research article in a scientific journal) - An unbiased in vitro screen for activating epidermal growth factor receptor mutations  (2019)  
- Journal of Biological Chemistry
 
(A1 Refereed original research article in a scientific journal) - L1TD1 - a prognostic marker for colon cancer  (2019)  
- BMC Cancer
 
(A1 Refereed original research article in a scientific journal) - Different responses of colorectal cancer cells to alternative sequences of cetuximab and oxaliplatin  (2018)  
- Scientific Reports
 
(A1 Refereed original research article in a scientific journal) - Receptor tyrosine kinase profiling of ischemic heart identifies ROR1 as a potential therapeutic target  (2018)  
- BMC Cardiovascular Disorders
 
(A1 Refereed original research article in a scientific journal) - Transcriptional Repressor HIC1 Contributes to Suppressive Function of Human Induced Regulatory T Cells  (2018)  
- Cell Reports
 
(A1 Refereed original research article in a scientific journal) - The L1TD1 Protein Interactome Reveals the Importance of Post-transcriptional Regulation in Human Pluripotency  (2015)  
- Stem Cell Reports
 
(A1 Refereed original research article in a scientific journal) - Gene expression analysis in cancer microarray datasets, investigating the role of an Embryonic Stem Cell Factor in prognosis  (2014)   Chakroborty Deepankar
(G2 Master’s thesis, polytechnic Master’s thesis)