Deepankar Chakroborty
MSc
deecha@utu.fi +358 29 450 3786 Tykistökatu 6 Turku Biocity Office: 4137 ORCID identifier: https://orcid.org/0000-0002-3458-0205 |
Epidermal Growth Factor Receptor (EGFR), EGFR family; Receptor Tyrosine Kinases; Tyrosine Kinase inhibitors; Cancer; Cancer Biology; Bioinformatics; Functional Genomics; R statistical programming; Therapeutic resistance; High -throughput screen
I am a Doctoral student in the Turku Doctoral Programme of Molecular Medicine. I have a background in biotechnology and bioinformatics. Currently, I am pursuing my PhD under the joint supervision of Prof. Klaus Elenius and Dr. Laura Elo.
Efforts of functional characterization of cancer-associated somatic mutations in oncogenes have been largely incomprehensive because they do not encompass the large majority. I have developed a pipeline to analyze thousands of variants of an oncogenic kinase gene in a single assay, I call iSCREAM (in vitro SCReen for Activating Mutation). We are developing the iSCREAM workflow to preemptively identify and characterize on-target secondary mutations that can cause therapeutic resistance, and then subsequently identify therapies that would potentially work for those resistant mutations.
- An Unbiased Functional Genetics Screen Identifies Rare Activating ERBB4 Mutations (2022)
- Cancer Research Communications
(Refereed journal article or data article (A1)) - Novel tools for identification of oncogenic driver mutations (2022) Chakroborty Deepankar
(Doctoral dissertation (article) (G5)) - Identification of Predictive ERBB Mutations by Leveraging Publicly Available Cell Line Databases (2021)
- Molecular Cancer Therapeutics
(Refereed journal article or data article (A1)) - An unbiased in vitro screen for activating epidermal growth factor receptor mutations (2019)
- Journal of Biological Chemistry
(Refereed journal article or data article (A1)) - L1TD1 - a prognostic marker for colon cancer (2019)
- BMC Cancer
(Refereed journal article or data article (A1)) - Different responses of colorectal cancer cells to alternative sequences of cetuximab and oxaliplatin (2018)
- Scientific Reports
(Refereed journal article or data article (A1)) - Receptor tyrosine kinase profiling of ischemic heart identifies ROR1 as a potential therapeutic target (2018)
- BMC Cardiovascular Disorders
(Refereed journal article or data article (A1)) - Transcriptional Repressor HIC1 Contributes to Suppressive Function of Human Induced Regulatory T Cells (2018)
- Cell Reports
(Refereed journal article or data article (A1)) - The L1TD1 Protein Interactome Reveals the Importance of Post-transcriptional Regulation in Human Pluripotency (2015)
- Stem Cell Reports
(Refereed journal article or data article (A1)) - Gene expression analysis in cancer microarray datasets, investigating the role of an Embryonic Stem Cell Factor in prognosis (2014) Chakroborty Deepankar
(Master’s thesis, polytechnic Master’s thesis (G2))