Pieta Mattila
InFLAMES Group Leader, Adjunct Professor
MediCity Research Laboratories, Turku Bioscience Centre pieta.mattila@utu.fi +358 29 450 4431 Tykistökatu 6 Turku ORCID identifier: https://orcid.org/0000-0003-2805-0686 |
Immunology
B cells
Antigen receptor signaling
Cell biology
Actin cytoskeleton
Plasma membrane
Advanced microscopy
Education:
MSc in Biochemistry 2002 (University of Oulu, Finland)
PhD in Genetics 2008 (University of Helsinki)
Postdoc: Cancer Research UK, London Research Institute 2008-2012
Adjunct Professor: 2014
Group leader in the InFLAMES research flagship 2022-> (University of Turku)
Academy of Finland Research Fellow 2016-2022 (University of Turku)
B lymphocytes are key cells in mounting the adaptive immune response by differentiating into antibody secreting plasma cells. Our group is interested in the molecular mechanisms of B lymphocyte activation, with emphasis on receptor activation and its immediate cell biological responses, culminating at the reorganization of the actin cytoskeleton, plasma membrane and intracellular vesicle traffic. In our research, we take advantage of both in vivo models and various advanced imaging techniques, including super-resolution microscopy, as well as modern proteomic approaches such as APEX2 proximity biotinylation.
More information about our projects, including our publications, can be found at: http://mattilalab.utu.fi.
I am lecturing on various Master’s and PhD level courses on topics including the adaptive immune system, cell signaling, cytoskeleton, and microscopy. I have been involved in designing new courses targeted for PhD students and postdocs. I have done University Pedagogics 1 course to develop my pedagogic skills. At every day level, I am supervising
doctoral students, postdocs, as well as guide Master’s thesis projects.
- The Small Rho GTPase TC10 Modulates B Cell Immune Responses (2017)
- Journal of Immunology
(A1 Refereed original research article in a scientific journal) - Dynamics of the actin cytoskeleton mediates receptor cross talk: An emerging concept in tuning receptor signaling (2016)
- Journal of Cell Biology
(A2 Refereed review article in a scientific journal ) - Nanoscale organization and dynamics of the siglec CD22 cooperate with the cytoskeleton in restraining BCR signalling (2016)
- EMBO Journal
(A1 Refereed original research article in a scientific journal) - IRF4 Deficiency Leads to Altered BCR Signalling Revealed by Enhanced PI3K Pathway, Decreased SHIP Expression and Defected Cytoskeletal ResponsesContractility-dependent actin dynamics in cardiomyocyte sarcomeres (2015)
- Scandinavian Journal of ImmunologyTraffic
(A1 Refereed original research article in a scientific journal) - MIM-Induced Membrane Bending Promotes Dendritic Spine Initiation. Molecular Mechanisms of Membrane Deformation by I-BAR Domain Proteins (2015) Saarikangas J, Kourdougli N, Senju Y, Chazal G, Segerstråle M, Minkeviciene R, Kuurne J, Mattila PK, Garrett L, Hölter SM, Becker L, Racz I, Hans W, Klopstock T, Wurst W, Zimmer A, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, von Ossowski L, Taira T, Lappalainen P, Rivera C, Hotulainen P.
(A1 Refereed original research article in a scientific journal) - Molecular Control of B Cell Activation and Immunological Synapse Formation (2015)
(A2 Refereed review article in a scientific journal ) - The Actin and Tetraspanin Networks Organize Receptor Nanoclusters to Regulate B Cell Receptor-Mediated SignalingABBA regulates plasma-membrane and actin dynamics to promote radial glia extension (2013)
- ImmunityJournal of Cell Science
(A1 Refereed original research article in a scientific journal) - (2009)
- Journal of Cell Science
(A1 Refereed original research article in a scientific journal) - (2009)
- Current Biology
(A1 Refereed original research article in a scientific journal) - (2008)
(A1 Refereed original research article in a scientific journal)



