Mikko Koivumäki

- Doctoral Researcher,
Imaging and Clinical Diagnostics (Department of Clinical Medicine)
- Doctoral Researcher,
Turku PET Centre (Independent units)

mikkkoi@utu.fi

: https://orcid.org/0000-0001-5641-9677

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Effects of reducing sedentary behavior on liver insulin sensitivity, liver fat content, and liver enzyme levels : a six-month randomized controlled trial (2025)
- American Journal of Physiology : Endocrinology and Metabolism
Laine, Saara; Sjöros, Tanja; Garthwaite, Taru; Honka, Miikka-Juhani; Löyttyniemi, Eliisa; Norha, Jooa; Eskola, Olli; Koivumäki, Mikko; Vähä-Ypyä, Henri; Sievänen, Harri; Vasankari, Tommi; Hirvonen, Jussi; Laitinen, Kirsi; Houttu, Noora; Kalliokoski, Kari K.; Saunavaara, Virva; Knuuti, Juhani; Heinonen, Ilkka H. A.
The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions (2025)
- Journal of Neuroinflammation
Takalo, Mari; Jeskanen, Heli; Rolova, Taisia; Kervinen, Inka; Hellén, Marianna; Heikkinen, Sami; Koivisto, Hennariikka; Jokivarsi, Kimmo; Müller, Stephan A.; Koivumäki, Esa-Mikko; Mäkinen, Petra; Juopperi, Sini-Pauliina; Willman, Roosa-Maria; Sinisalo, Rosa; Hoffmann, Dorit; Jäntti, Henna; Peitz, Michael; Fließbach, Klaus; Kuulasmaa, Teemu; Natunen, Teemu; Kemppainen, Susanna; Poutiainen, Pekka; Leinonen, Ville; Malm, Tarja; Martiskainen, Henna; Ramirez, Alfredo; Haapasalo, Annakaisa; Lichtenthaler, Stefan F.; Tanila, Heikki; Haass, Christian; Rinne, Juha; Koistinaho, Jari; Hiltunen, Mikko
Blood biomarkers of neurodegeneration associate differently with amyloid deposition, medial temporal atrophy, and cerebrovascular changes in APOE ε4-enriched cognitively unimpaired elderly (2024)
- Alzheimer's Research and Therapy
Koivumäki Mikko, Ekblad Laura, Lantero-Rodriguez Juan, Ashton Nicholas J., Karikari Thomas K., Helin Semi, Parkkola Riitta, Lötjönen Jyrki, Zetterberg Henrik, Blennow Kaj, Rinne Juha O., Snellman Anniina
Daily standing time, dietary fiber, and intake of unsaturated fatty acids are beneficially associated with hepatic insulin sensitivity in adults with metabolic syndrome (2024)
- Frontiers in Endocrinology
Laine, Saara; Sjöros, Tanja; Garthwaite, Taru; Honka, Miikka-Juhani; Löyttyniemi, Eliisa; Eskola, Olli; Saarenhovi, Maria; Kallio, Petri; Koivumäki, Mikko; Vähä-Ypyä, Henri; Sievänen, Harri; Vasankari, Tommi; Hirvonen, Jussi; Laitinen, Kirsi; Houttu, Noora; Kalliokoski, Kari; Saunavaara, Virva; Knuuti, Juhani; Heinonen, Ilkka H.A.
P2X 7-receptor binding in new-onset and secondary progressive MS – a [11C]SMW139 PET study (2024)
- EJNMMI Research
Lehto, Jussi; Aarnio, Richard; Tuisku, Jouni; Sucksdorff, Marcus; Koivumäki, Esa Mikko; Nylund, Marjo; Helin, Semi; Rajander, Johan; Danon, Jonathan; Gilchrist, Jayson; Kassiou, Michael; Oikonen, Vesa; Airas, Laura
Sedentary time associates detrimentally and physical activity beneficially with metabolic flexibility in adults with metabolic syndrome (2024)
- American Journal of Physiology : Endocrinology and Metabolism
Garthwaite Taru, Sjöros Tanja, Laine Saara, Koivumäki Mikko, Vähä-Ypyä Henri, Verho Tiina, Norha Jooa, Kallio Petri, Saarenhovi Maria, Löyttyniemi Eliisa, Sievänen Harri, Houttu Noora, Laitinen Kirsi, Kalliokoski Kari K., Vasankari Tommi, Knuuti Juhani, Heinonen Ilkka
SV2A PET shows hippocampal synaptic loss in cognitively unimpaired APOE ε4/ε4 homozygotes (2024)
- Alzheimer's and Dementia
Snellman, Anniina; Tuisku, Jouni; Koivumäki, Mikko; Wahlroos, Saara; Aarnio, Richard; Rajander, Johan; Karrasch, Mira; Ekblad, Laura L.; Rinne, Juha O.
Synaptic density in multiple sclerosis: An in vivo study using [11C]UCB-J-PET imaging (2024)
- Multiple Sclerosis
Luoma, Amelie; Matilainen, Markus; Tuisku, Jouni; Aarnio, Richard; Nikkila, Taru; Laaksonen, Sini; Koivumaki, Mikko; Honkonen, Eveliina; Nylund, Marjo; Wahlroos, Saara; Toyonaga, Takuya; Chen, Ming-Kai; Lehto, Jussi; Snellman, Anniina; Rinne, Juha; Airas, Laura
APOE ε4 gene dose effect on imaging and blood biomarkers of neuroinflammation and beta-amyloid in cognitively unimpaired elderly (2023)
- Alzheimer's Research and Therapy
Snellman Anniina, Ekblad Laura L., Tuisku Jouni, Koivumäki Mikko, Ashton Nicholas J., Lantero-Rodriguez Juan, Karikari Thomas K., Helin Semi, Bucci Marco, Löyttyniemi Eliisa, Parkkola Riitta, Karrasch Mira, Schöll Michael, Zetterberg Henrik, Blennow Kaj, Rinne Juha O.
Associations of sedentary time, physical activity, and fitness with muscle glucose uptake in adults with metabolic syndrome (2023)
- Scandinavian Journal of Medicine and Science in Sports
Garthwaite Taru, Sjöros Tanja, Laine Saara, Koivumäki Mikko, Vähä-Ypyä Henri, Eskola Olli, Rajander Johan, Kallio Petri, Saarenhovi Maria, Löyttyniemi Eliisa, Sievänen Harri, Houttu Noora, Laitinen Kirsi, Kalliokoski Kari, Vasankari Tommi, Knuuti Juhani, Heinonen Ilkka
Head-to-head comparison of plasma p-tau181, p-tau231 and glial fibrillary acidic protein in clinically unimpaired elderly with three levels of APOE4-related risk for Alzheimer's disease (2023)
- Neurobiology of Disease
Snellman Anniina, Ekblad Laura L., Ashton Nicholas J., Karikari Thomas K., Lantero-Rodriguez Juan, Pietilä Elina, Koivumäki Mikko, Helin Semi, Karrasch Mira, Zetterberg Henrik, Blennow Kaj, Rinne Juha O.
Insulin resistance and body mass index are associated with TSPO PET in cognitively unimpaired elderly (2023)
- Journal of Cerebral Blood Flow and Metabolism
Ekblad Laura L, Tuisku Jouni, Koivumäki Mikko, Helin Semi, Rinne Juha O, Snellman Anniina
Reducing Sedentary Time and Whole-Body Insulin Sensitivity in Metabolic Syndrome - A 6-Month Randomized Controlled Trial (2023)
- Medicine and Science in Sports and Exercise
Sjöros Tanja, Laine Saara, Garthwaite Taru, Vähä-Ypyä Henri, Löyttyniemi Eliisa, Koivumäki Mikko, Houttu Noora, Laitinen Kirsi, Kalliokoski Kari K., Sievänen Harri, Vasankari Tomi, Knuuti Juhani, Heinonen Ilkka H.A.
The effects of a 6-month intervention aimed to reduce sedentary time on skeletal muscle insulin sensitivity: a randomized controlled trial (2023)
- American Journal of Physiology : Endocrinology and Metabolism
Sjöros Tanja, Laine Saara, Garthwaite Taru, Vähä-Ypyä Henri, Koivumäki Mikko, Eskola Olli, Löyttyniemi Eliisa, Houttu Noora, Laitinen Kirsi, Kalliokoski Kari K., Sievänen Harri, Vasankari Tommi, Knuuti Juhani, Heinonen Ilkka H.A.
ASIC-E4: Interplay of Beta-Amyloid, Synaptic Density and Neuroinflammation in Cognitively Normal Volunteers With Three Levels of Genetic Risk for Late-Onset Alzheimer's Disease - Study Protocol and Baseline Characteristics (2022)
- Frontiers in Neurology
Snellman Anniina, Ekblad Laura L, Koivumäki Mikko, Lindgren Noora, Tuisku Jouni, Perälä Merja, Kallio Lila, Lehtonen Riina, Saunavaara Virva, Saunavaara Jani, Oikonen Vesa, Aarnio Richard, Löyttyniemi Eliisa, Parkkola Riitta Karrasch Mira, Zetterberg Henrik, Blennow Kaj, Rinne Juha O
Corrigendum to “Standing is associated with insulin sensitivity in adults with metabolic syndrome. Journal of Science and Medicine in Sport 24 (2021) 1255–1260” (Journal of Science and Medicine in Sport (2021) 24(12) (1255–1260), (S1440244021002048), (10.1016/j.jsams.2021.08.009)) (2022)
- Journal of Science and Medicine in Sport
Garthwaite Taru, Sjöros Tanja, Koivumäki Mikko, Laine Saara, Vähä-Ypyä Henri, Saarenhovi Maria, Kallio Petri, Löyttyniemi Eliisa, Sievänen Harri, Houttu Noora, Laitinen Kirsi, Kalliokoski Kari, Vasankari Tommi, Knuuti Juhani, Heinonen Ilkka
First-in-Human Study of 68 Ga-DOTA-Siglec-9, PET Ligand Targeting Vascular Adhesion Protein 1 (2021)
- Journal of Nuclear Medicine
Viitanen Riikka, Moisio Olli Antero, Lankinen Petteri, Li Xiang-Guo, Koivumäki Mikko, Suilamo Sami, Tolvanen Tuula, Taimen Kirsi, Mali Markku, Kohonen Ia, Koskivirta Ilpo, Oikonen Vesa, Virtanen Helena, Santalahti Kristiina, Autio Anu, Saraste Antti, Pirilä Laura, Nuutila Pirjo, Knuuti Juhani, Jalkanen Sirpa, Roivainen Anne
Standing is associated with insulin sensitivity in adults with metabolic syndrome (2021)
- Journal of Science and Medicine in Sport
Garthwaite Taru, Sjöros Tanja, Koivumäki Mikko, Laine Saara, Vähä-Ypyä Henri, Saarenhovi Maria, Kallio Petri, Löyttyniemi Eliisa, Sievänen Harri, Houttu Noora, Laitinen Kirsi, Kalliokoski Kari, Vasankari Tommi, Knuuti Juhani, Heinonen Ilkka
Intramyocellular lipid accumulation after sprint interval and moderate-intensity continuous training in healthy and diabetic subjects (2019)
- Physiological Reports
Sjoros T, Saunavaar V, Loyttyniemi E, Koivumaki M, Heinonen IHA, Eskelinen JJ, Virtanen KA, Hannukainen JC, Kalliokoski KK
Unsupervised phrase-level query rewriting for assisting search in clinical free text (2019)
- World congress on medical and health informatics
MEDINFO 2019: Health and Wellbeing e-Networks for All. Proceedings of the 17th World Congress on Medical and Health Informatics Moen H., Peltonen L., Suhonen H., Koivumäki M., Salakoski T., Salanterä S.