Olli Tenovuo
MD, PhD, Prof. of Neurotraumatology
traumatic brain injury; rehabilitation; biomarkers; imaging
Pathophysiology, diagnostics, treatment, and prognosis of traumatic brain injury
I have a long and profound experience in the field of traumatic brain injuries (TBIs), both clinically and scientifically. Patients with TBI of different severities have been my main clinical interest since early 1990’s, and during the years I have treated about 6 000 patients with TBI. Since 1996 I have led a multidisciplinary research group on TBIs, which has expanded steadily. Currently our group includes > 40 researchers, 21 of which are PhD students and 7 are post docs. They represent widely different disciplines, such as neurosurgery, neurology, neuroanaesthesiology, neuroradiology, neuropsychology, clinical neurophysiology, psychiatry etc. I have conducted also large international research projects and am currently in a leading position in several trials. I have also experience on RCTs on the field. My group has a wide collaborative network both nationally and internationally, both in experimental and clinical research. Currently we have active research collaboration with ten national and 22 international (from 13 countries) research groups.
The research of our TBI has included topics from various disciplines, from psychiatry and neuropsychology to epidemiology, neurosurgery, and biochemistry. During the recent years we have mainly focused in three areas: 1) blood-based brain injury biomarkers, 2) novel brain imaging methodologies, and 3) multifaceted approach to diagnostic and prognostic modeling of TBI. We aim at solving clinical problems and conducting research which is easily transferred to clinical practice. We also collaborate with basic science in order to reveal brain injury mechanisms, since these help in understanding clinical phenomena and in developing new interventions. International collaboration and co-work are an essential part of our research policy.
Teaching about TBI has been a major part of my work for almost 20 years, both for medical students at the Turku University as well as nationally and internationally. Annually I have about 160 hrs of teaching for medical students.
- Injury profiles, demography and representativeness of patients with TBI attending a regional emergency department (2016) Ala-Seppala H, Heino I, Frantzen J, Takala RSK, Katila AJ, Kyllonen A, Maanpaa HR, Posti JP, Tallus J, Tenovuo O
- Peripheral nervous system involvement in primary burning mouth syndromeresults of a pilot study (2016) Puhakka A, Forssell H, Soinila S, Virtanen A, Roytta M, Laine M, Tenovuo O, Teerijoki-Oksa T, Jaaskelainen SK
- Pohjoismainen hoitosuositus avuksi pään vammojen arviointiin (2016) Luoto T, Tenovuo O
- Prediction of Outcome after Traumatic Brain Injury: Comparison of Disease State Index and IMPACT Calculator (2016)
- Studies in Health Technology and Informatics
Liedes H, Mattila J, Lingsma H, Lötjönen J, Menon D, Tenovuo O, van Gils M
- Reproducibility of Tract-based and Region-of-Interest DTI Analysis of Long Association Tracts (2016) Brandstack N., Kurki T., Laalo J., Kauko T., Tenovuo O.
- Scandinavian guidelines for initial management of minor and moderate head trauma in children (2016) Astrand R, Rosenlund C, Undén J; and for the Scandinavian Neurotrauma Committee (SNC)
- The Cholinergic Potential, the Vagus Nerve and Challenges in Treatment of Traumatic Brain Injury (2016)
- Current Pharmaceutical Design
Uteshev VV, Tenovuo O, Gaidhani N
- The Levels of Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 During the First Week After a Traumatic Brain Injury: Correlations With Clinical and Imaging Findings (2016) Posti JP, Takala RSK, Runtti H, Newcombe VF, Outtrim J, Katila AJ, Frantzen J, Ala-Seppala H, Coles JP, Hossain MI, Kyllonen A, Maanpaa HR, Tallus J, Hutchinson PJ, van Gils M, Menon DK, Tenovuo O
- Variation in structure and process of care in traumatic brain injury: Provider profiles of European Neurotrauma Centers participating in the CENTER-TBI study (2016) Cnossen M., Polinder S., Lingsma H., Maas A., Menon D., Steyerberg E., Adams H., Alessandro M., Allanson J., Amrein K., Andaluz N., Andelic N., Andrea N., Andreassen L., Anke A., Antoni A., Ardon H., Audibert G., Auslands K., Azouvi P., Baciu C., Bacon A., Badenes R., Baglin T., Bartels R., Barzó P., Bauerfeind U., Beer R., Belda F., Bellander B., Belli A., Bellier R., Benali H., Benard T., Berardino M., Beretta L., Beynon C., Bilotta F., Binder H., Biqiri E., Blaabjerg M., Borgen L., Bouzat P., Bragge P., Brazinova A., Brehar F., Brorsson C., Buki A., Bullinger M., Bučková V., Calappi E., Cameron P., Carbayo L., Carise E., Carpenter C., Castaño-León A., Causin F., Chevallard G., Chieregato A., Citerio G., Coburn M., Coles J., Cooper J., Correia M., Covic A., Curry N., Czeiter E., Czosnyka M., Dahyot-Fizelier C., Damas F., Damas P., Dawes H., De Keyser V., Della Corte F., Depreitere B., Ding S., Dippel D., Dizdarevic K., Dulière G., Dzeko A., Eapen G., Engemann H., Ercole A., Esser P., Ezer E., Fabricius M., Feigin V., Feng J., Foks K., Fossi F., Francony G., Frantzén J., Freo U., Frisvold S., Furmanov A., Gagliardo P., Galanaud D., Gao G., Geleijns K., Ghuysen A., Giraud B., Glocker B., Gomez P., Grossi F., Gruen R., Gupta D., Haagsma J., Hadzic E., Haitsma I., Hartings J., Helbok R., Helseth E., Hertle D., Hill S., Hoedemaekers A., Hoefer S., Hutchinson P., Håberg A., Jacobs B., Janciak I., Janssens K., Jiang J., Jones K., Kalala J., Kamnitsas K., Karan M., Karau J., Katila A., Kaukonen M., Keeling D., Kerforne T., Ketharanathan N., Kettunen J., Kivisaari R., Kolias A., Kolumbán B., Kompanje E., Kondziella D., Koskinen L., Kovács N., Kálovits F., Lagares A., Lanyon L., Laureys S., Lauritzen M., Lecky F., Ledig C., Lefering R., Legrand V., Lei J., Levi L., Lightfoot R., Lingsma H., Loeckx D., Lozano A., Luddington R., Luijten-Arts C., Maas A., MacDonald S., MacFayden C., Maegele M., Majdan M., Major S., Manara A., Manhes P., Manley G., Martin D., Martino C., Maruenda A., Maréchal H., Mastelova D., Mattern J., McMahon C., Melegh B., Menovsky T., Morganti-Kossmann C., Mulazzi D., Mutschler M., Mühlan H., Negru A., Nelson D., Neugebauer E., Newcombe V., Noirhomme Q., Nyirádi J., Oddo M., Oldenbeuving A., Oresic M., Ortolano F., Palotie A., Parizel P., Patruno A., Payen J., Perera N., Perlbarg V., Persona P., Peul W., Pichon N., Piilgaard H., Piippo A., Pili F., Pirinen M., Ples H., Pomposo I., Psota M., Pullens P., Puybasset L., Ragauskas A., Raj R., Rambadagalla M., Rehorčíková V., Rhodes J., Richardson S., Ripatti S., Rocka S., Rodier N., Roe C., Roise O., Roks G., Romegoux P., Rosand J., Rosenfeld J., Rosenlund C., Rosenthal G., Rossaint R., Rossi S., Rostalski T., Rueckert D., Ruiz De Arcaute F., Rusnák M., Sacchi M., Sahakian B., Sahuquillo J., Sakowitz O., Sala F., Sanchez-Pena P., Sanchez-Porras R., Sandor J., Santos E., Sasse N., Sasu L., Savo D., Schipper I., Schlößer B., Schmidt S., Schneider A., Schoechl H., Schoonman G., Schou R., Schwendenwein E., Schöll M., Sir Ö., Skandsen T., Smakman L., Smeets D., Smielewski P., Sorinola A., Stamatakis E., Stanworth S., Stegemann K., Steinbüchel N., Stevens R., Stewart W., Stocchetti N., Sundström N., Synnot A., Szabó J., Söderberg J., Taccone F., Tamás V., Tanskanen P., Tascu A., Taylor M., Te Ao B., Tenovuo O., Teodorani G., Theadom A., Thomas M., Tibboel D., Tolias C., Tshibanda J., Tudora C., Vajkoczy P., Valeinis E., Van Hecke W., Van Praag D., Van Roost D., Van Vlierberghe E., Vande Vyvere T., Vanhaudenhuyse A., Vargiolu A., Vega E., Verheyden J., Vespa P., Vik A., Vilcinis R., Vizzino G., Vleggeert-Lankamp C., Volovici V., Vulekovic P., Vámos Z., Wade D., Wang K., Wang L., Wildschut E., Williams G., Willumsen L., Wilson A., Wilson L., Winkler M., Ylén P., Younsi A., Zaaroor M., Zhang Z., Zheng Z., Zumbo F., De Lange S., De Ruiter G., Den Boogert H., Van Dijck J., Van Essen T., Van Heugten C., Van Der Jagt M., Van Der Naalt J., Polinder S., Cnossen M., Van Der Naalt J., Zumbo F., De Lange S., De Ruiter G., Den Boogert H., Van Dijck J., Van Essen T., Van Heugten C., Van Der Jagt M., Wilson L., Wilson A., Ylén P., Winkler M., Zaaroor M., Younsi A., Zheng Z., Zhang Z., Willumsen L.
- Clinical correlates of retrograde amnesia in mild traumatic brain injury (2015) Luoto TM, Iverson GL, Losoi H, Waljas M, Tenovuo O, Kataja A, Brander A, Ohman J
- Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI): A Prospective Longitudinal Observational Study. (2015) Maas AI, Menon DK, Steyerberg EW, Citerio G, Lecky F, Manley GT, Hill S, Legrand V, Sorgner A; on behalf of the CENTER-TBI Participants and Investigators
- Outcomes from mild and moderate traumatic brain injuries among children and adolescents: A systematic review of studies from 2008-2013 (2015) Lloyd J, Wilson ML, Tenovuo O, Saarijarvi S
- Aivovammojen diagnostiikka on kehittymässä (2014) Kurki T, Tenovuo O
- Automatic Quantification of CT Images for Traumatic Brain Injury (2014)
- International Symposium on Biomedical Imaging
2014 IEEE 11th International Symposium on Biomedical Imaging (ISBI) Koikkalainen J, Lotjonen J, Ledig C, Rueckert D, Tenovuo O, Menon D
- Blood Metabolic Patterns Correlate With the Severity of Traumatic Brain Injury (2014) Jussi Posti, Tuulia Hyötyläinen, Sirkku Jäntti, Henna Ala-Seppälä, Jonathan Coles, Ari Katila, Anna Kyllönen, Henna-Riikka Maanpää, David K Menon, Joanne Outrim, Peter J Hutchinson, Keri Carpenter, Jussi Tallus, Marko Sysi-Aho, Riikka Takala, Matej Orea, Olli Tenovuo
- Consistent and Robust 4D Whole-Brain Segmentation: Application to Traumatic Brain Injury (2014)
- International Symposium on Biomedical Imaging
2014 IEEE 11th International Symposium on Biomedical Imaging (ISBI) Ledig C, Shi WZ, Makropoulos A, Koikkalainen J, Heckemann RA, Hammers A, Lotjonen J, Tenovuo O, Rueckert D
- Diffusion tensor tractography-based analysis of the cingulum: clinical utility and findings in traumatic brain injury with chronic sequels. (2014) Kurki T, Himanen L, Vuorinen E, Myllyniemi A, Saarenketo AR, Kauko T, Brandstack N, Tenovuo O
- Interpretation of magnetic resonance imaging in the chronic phase of traumatic brain injury – What is missed in the original reports? (2014) Laalo JP, Kurki TJ, Tenovuo OS
- Smoking and outcome of traumatic brain injury (2014) Östberg A, Tenovuo O
- Sport concussion assessment tool 2 in a civilian trauma sample with mild traumatic brain injury (2014) Teemu M. Luoto, Noah D. Silverberg, Anneli Kataja, Antti Brander, Olli Tenovuo, Juha Öhman, Grant L. Iverson
