Olli Tenovuo
MD, PhD, Prof. of Neurotraumatology
traumatic brain injury; rehabilitation; biomarkers; imaging
Pathophysiology, diagnostics, treatment, and prognosis of traumatic brain injury
I have a long and profound experience in the field of traumatic brain injuries (TBIs), both clinically and scientifically. Patients with TBI of different severities have been my main clinical interest since early 1990’s, and during the years I have treated about 6 000 patients with TBI. Since 1996 I have led a multidisciplinary research group on TBIs, which has expanded steadily. Currently our group includes > 40 researchers, 21 of which are PhD students and 7 are post docs. They represent widely different disciplines, such as neurosurgery, neurology, neuroanaesthesiology, neuroradiology, neuropsychology, clinical neurophysiology, psychiatry etc. I have conducted also large international research projects and am currently in a leading position in several trials. I have also experience on RCTs on the field. My group has a wide collaborative network both nationally and internationally, both in experimental and clinical research. Currently we have active research collaboration with ten national and 22 international (from 13 countries) research groups.
The research of our TBI has included topics from various disciplines, from psychiatry and neuropsychology to epidemiology, neurosurgery, and biochemistry. During the recent years we have mainly focused in three areas: 1) blood-based brain injury biomarkers, 2) novel brain imaging methodologies, and 3) multifaceted approach to diagnostic and prognostic modeling of TBI. We aim at solving clinical problems and conducting research which is easily transferred to clinical practice. We also collaborate with basic science in order to reveal brain injury mechanisms, since these help in understanding clinical phenomena and in developing new interventions. International collaboration and co-work are an essential part of our research policy.
Teaching about TBI has been a major part of my work for almost 20 years, both for medical students at the Turku University as well as nationally and internationally. Annually I have about 160 hrs of teaching for medical students.
- Serum Metabolites Associated with Computed Tomography Findings after Traumatic Brain Injury (2018) Dickens AM, Posti JP, Takala RSK, Ala-Seppala H, Mattila I, Coles JP, Frantzen J, Hutchinson PJ, Katila AJ, Kyllonen A, Maanpaa HR, Newcombe V, Outtrim J, Tallus J, Carpenter KLH, Menon DK, Hyotylainen T, Tenovuo O, Oresic M, Oresic M
- Traumatic brain injury: Patient experience and satisfaction with discharge from trauma hospital (2018)
- Journal of Rehabilitation Medicine
Tverdal CB, Howe EI, Roe C, Helseth E, Lu J, Tenovuo O, Andelic N
- USABILITY OF WORLD HEALTH ORGANIZATION DISABILITY ASSESSMENT SCHEDULE IN CHRONIC TRAUMATIC BRAIN INJURY (2018)
- Journal of Rehabilitation Medicine
Tarvonen-Schroder S, Tenovuo O, Kaljonen A, Laimi K
- Variation in Blood Transfusion and Coagulation Management in Traumatic Brain Injury at the Intensive Care Unit: A Survey in 66 Neurotrauma Centers Participating in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Study (2018) Huijben JA, van der Jagt M, Cnossen MC, Kruip MJHA, Haitsma I, Stocchetti N, Maas A, Menon D, Ercole A, Maegele M, Stanworth SJ, Citerio G, Polinder S, Steyerberg EW, Lingsma H; the on behalf of Investigators CENTER-TBI and Participants
- Variation in general supportive and preventive intensive care management of traumatic brain injury: a survey in 66 neurotrauma centers in participating in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study (2018) Hujiben JA, Volovici V, Cnossen MC, Haitsma IK, Stocchetti N, Maas AIR, Menon DK, Ercole A, Citerio G, Nelson D, Polinder S, Steyerberg EW, Lingsma HF, van der Jagt M; CENTER-TBI investigators and participants
- GFAP and UCH-I1 as predictors of outcome in mild and moderate traumatic brain injury (2017) Hossain I, Posti J, Takala R, Mohammadian M, Outtrim J, Katila A, Frantzen J, Ala-Seppala H, Coles J, Kyllonen A, Maanpaa HR, Tallus J, Hutchinson P, Van Gils M, Menon D, Tenovuo O
- Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 Are Not Specific Biomarkers for Mild CT-Negative Traumatic Brain Injury (2017) Posti JP, Hossain MI, Takala RS, Liedes H, Newcombe V, Outtrim J, Katila AJ, Frantzén J, Ala-Seppälä HM, Coles JC, Kyllönen A, Maanpää HR, Tallus J, Hutchinson PJ, Van Gils M, Menon D, Tenovuo O
- Health professionals' perception on the traumatic brain injury care pathways: A SWOT analysis (2017) Andelic N, Roe C, Azouvi P, Dawes H, Majdan M, Tenovuo O
- High angular resolution diffusion-weighted imaging in mild traumatic brain injury (2017) Mohammadian M, Roine T, Hirvonen J, Kurki T, Ala-Seppala H, Frantzen J, Katila A, Kyllönen A, Maanpää HR, Posti J, Takala R, Tallus J, Tenovuo O
- Management of mild traumatic brain injury at the emergency department and hospital admission in Europe: A survey of 71 neurotrauma centers participating in the CENTER-TBI study (2017) Foks Kelly A., Cnossen Maryse C., Dippel Diederik W.J., Maas Andrew I.R., Menon David, van der Naalt Joukje, Steyerberg Ewout W., Lingsma Hester F., Polinder Suzanne; and on behalf of CENTER-TBI investigators and participants
- Metabolomics profiling as a diagnostic tool in severe traumatic brain injury (2017) Jussi P. Posti, Alex M. Dickens, Matej Orešič, Tuulia Hyötyläinen, Olli Tenovuo
- Neuroinflammation following traumatic brain injury: A positron emission tomography study (2017) Mehrbod Mohammadian, Jouni Tuisku, Jussi Hirvonen, Riitta Parkkola, Pekka Jokinen, Eero Rissanen, Olli Tenovuo
- Pediatric TBI in Finland: An examination of hospital discharges (1998-2012) (2017)
- European Journal of Paediatric Neurology
L Wilson M, Tenovuo O, Mattila VM, Gissler M, Celedonia KL, Impinen A, Saarijärvi S.
- Regional brain morphometry in patients with traumatic brain injury based on acute- and chronic-phase magnetic resonance imaging (2017) Ledig C, Kamnitsas K, Koikkalainen J, Posti JP, Takala RSK, Katila A, Frantzen J, Ala-Seppala H, Kyllonen A, Maanpaa HR, Tallus J, Lotjonen J, Glocker B, Tenovuo O, Rueckert D
- Rehabilitation after traumatic brain injury: A survey in 70 European neurotrauma centres participating in the CENTER-TBI study (2017)
- Journal of Rehabilitation Medicine
Cnossen MC, Lingsma HF, Tenovuo O, Maas AIR, Menon D, Steyerberg EW, Ribbers GM, Polinder S
- Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research (2017) Maas AIR, Menon DK, Adelson PD, Andelic N, Bell MJ, Belli A, Bragge P, Brazinova A, Burki A, Chesnut RM, Citerio G, Coburn M, Cooper DJ, Crowder AT, Czeiter E, Czosnyka M, Diaz-Arrastia R, Dreier JP, Duhaime AC, Ercole A, van Essen TA, Feigin VL, Gao GY, Giacino J, Gonzalez-Lara LE, Gruen RL, Gupta D, Hartings JA, Hill S, Jiang JY, Ketharanathan N, Kompanje EJO, Lanyon L, Laureys S, Lecky F, Levin H, Lingsma HF, Maegele M, Majdan M, Manley G, Marsteller J, Mascia L, McFadyen C, Mondello S, Newcombe V, Palotie A, Parizel PM, Peul W, Piercy J, Polinder S, Puybasset L, Rasmussen TE, Rossaint R, Smielewski P, Soderberg J, Stanworth SJ, Stein MB, von Steinbuchel N, Stewart W, Steyerberg EW, Stocchetti N, Synnot A, Ao BT, Tenovuo O, Theadom A, Tibboel D, Videtta W, Wang KKW, Williams WH, Wilson L, Yaffe K; for the InTBIR Participants and Investigators
- Variation in monitoring and treatment policies for intracranial hypertension in traumatic brain injury: A survey in 66 neurotrauma centers participating in the CENTER-TBI study (2017) Cnossen M., Huijben J., van der Jagt M., Volovici V., van Essen T., Polinder S., Nelson D., Ercole A., Stocchetti N., Citerio G., Peul W., Maas A., Menon D., Steyerberg E., Lingsma H., Adams H., Alessandro M., Allanson J., Amrein K., Andaluz N., Andelic N., Andrea N., Andreassen L., Anke A., Antoni A., Ardon H., Audibert G., Auslands K., Azouvi P., Baciu C., Bacon A., Badenes R., Baglin T., Bartels R., Barzó P., Bauerfeind U., Beer R., Belda F., Bellander B., Belli A., Bellier R., Benali H., Benard T., Berardino M., Beretta L., Beynon C., Bilotta F., Binder H., Biqiri E., Blaabjerg M., Lund S., Bouzat P., Bragge P., Brazinova A., Brehar F., Brorsson C., Buki A., Bullinger M., Bucková V., Calappi E., Cameron P., Carbayo L., Carise E., Carpenter K., Castaño-León A., Causin F., Chevallard G., Chieregato A., Cooper M., Cnossen M., Coburn M., Coles J., Cooper J., Correia M., Covic A., Curry N., Czeiter E., Czosnyka M., Dahyot-Fizelier C., Damas F., Damas P., Dawes H., De Keyser V., Corte F., Depreitere B., Ding S., Dippel D., Dizdarevic K., Dulière G., Dzeko A., Eapen G., Engemann H., Ercole A., Esser P., Ezer E., Fabricius M., Feigin V., Feng J., Foks K., Fossi F., Francony G., Frantzén J., Freo U., Frisvold S., Furmanov A., Gagliardo P., Galanaud D., Gao G., Geleijns K., Ghuysen A., Giraud B., Glocker B., Gomez P., Grossi F., Gruen R., Gupta D., Haagsma J., Hadzic E., Haitsma I., Hartings J., Helbok R., Helseth E., Hertle D., Hill S., Hoedemaekers A., Hoefer S., Hutchinson P., Håberg K., Jacobs B., Janciak I., Janssens K., Jiang J., Jones K., Kalala J., Kamnitsas K., Karan M., Karau J., Katila A., Kaukonen M., Keeling D., Kerforne T., Ketharanathan N., Kettunen J., Kivisaari R., Kolias A., Kolumbán B., Kompanje E., Kondziella D., Koskinen L., Kovács N., Kálovits F., Lagares A., Lanyon L., Laureys S., Lauritzen M., Lecky F., Ledig C., Lefering R., Legrand V., Lei J., Levi L., Lightfoot R., Lingsma H., Loeckx D., Lozano A., Luddington R., Luijten-Arts C., Maas A., MacDonald S., MacFayden C., Maegele M., Majdan M., Major S., Manara A., Manhes P., Manley G., Martin D., Martino C., Maruenda A., Maréchal H., Mastelova D., Mattern J., McMahon C., Melegh B., Menon D., Menovsky T., Morganti-Kossmann C., Mulazzi D., Mutschler M., Mühlan H., Negru A., Nelson D., Neugebauer E., Newcombe V., Noirhomme Q., Nyirádi J., Oddo M., Oldenbeuving A., Oresic M., Ortolano F., Palotie A., Parizel P., Patruno A., Payen J., Perera N., Perlbarg V., Persona P., Peul W., Pichon N., Piilgaard H., Piippo A., Floury S., Pirinen M., Ples H., Polinder S., Pomposo I., Psota M., Pullens P., Puybasset L., Ragauskas A., Raj R., Rambadagalla M., Rehorcíková V., Rhodes J., Richardson S., Ripatti S., Rocka S., Rodier N., Roe C., Roise O., Roks G., Romegoux P., Rosand J., Rosenfeld J., Rosenlund C., Rosenthal G., Rossaint R., Rossi S., Rostalski T., Rueckert D., de Ruiz A., Rusnák M., Sacchi M., Sahakian B., Sahuquillo J., Sakowitz O., Sala F., Sanchez-Pena P., Sanchez-Porras R., Sandor J., Santos E., Sasse N., Sasu L., Savo D., Schipper I., Schlößer B., Schmidt S., Schneider A., Schoechl H., Schoonman G., Rico F., Schwendenwein E., Schöll M., Sir ö., Skandsen T., Smakman L., Smeets D., Smielewski P., Sorinola A., Stamatakis E., Stanworth S., Stegemann K., Steinbüchel N., Stevens R., Stewart W., Steyerberg E., Stocchetti N., Sundström N., Synnot A., Szabó J., Söderberg J., Taccone F., Tamás V., Tanskanen P., Tascu A., Taylor M., Te A., Tenovuo O., Teodorani G., Theadom A., Thomas M., Tibboel D., Tolias C., Tshibanda J., Tudora C., Vajkoczy P., Valeinis E., Hecke W., Praag D., Dirk V., Vlierberghe E., Vyvere T., Vanhaudenhuyse A., Vargiolu A., Vega E., Verheyden J., Vespa P., Vik A., Vilcinis R., Vizzino G., Vleggeert-Lankamp C., Volovici V., Vulekovic P., Vámos Z., Wade D., Wang K., Wang L., Wildschut E., Williams G., Willumsen L., Wilson A., Wilson L., Winkler M., Ylén P., Younsi A., Zaaroor M., Zhang Z., Zheng Z., Zumbo F., de Lange S., de Ruiter G., den Boogert H., van Dijck J., van Essen T., van Heugten C., van der Jagt M., van der Naalt J., Volovici V., van der Jagt M., Huijben J., Cnossen M., van der Naalt J., van der Jagt M., van Heugten C.
- Digital Gaming for Improving the Functioning of People With Traumatic Brain Injury: Protocol of a Feasibility Study (2016) Välimäki M, Korkeila J, Kauppi K, Kaakinen JK, Holm S, Vahlo J, Tenovuo O, Hämäläinen H, Sarajuuri J, Rantanen P, Orenius T, Koponen A
- Elevated blood GFAP and UCH-L1 levels in acute orthopaedic injuries without CNS involvement (2016) Posti J, Hossain I, Takala R, Liedes H, Newcombe V, Outtrim J, Katila A, Frantzen J, Ala-Seppala H, Coles J, Kyllonen A, Maanpaa HR, Tallus J, Hutchinson P, van Gils M, Menon D, Tenovuo O
- Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 as Outcome Predictors in Traumatic Brain Injury (2016) Takala RSK, Posti JP, Runtti H, Newcombe VF, Outtrim J, Katila AJ, Frantzen J, Ala-Seppala H, Kyllonen A, Maanpaa HR, Tallus J, Hossain MI, Coles JP, Hutchinson P, van Gils M, Menon DK, Tenovuo O
