Olli Tenovuo
MD, PhD, Prof. of Neurotraumatology
Department of Neurosciences ollten@utu.fi |
traumatic brain injury; rehabilitation; biomarkers; imaging
Pathophysiology, diagnostics, treatment, and prognosis of traumatic brain injury
I have a long and profound experience in the field of traumatic brain injuries (TBIs), both clinically and scientifically. Patients with TBI of different severities have been my main clinical interest since early 1990’s, and during the years I have treated about 6 000 patients with TBI. Since 1996 I have led a multidisciplinary research group on TBIs, which has expanded steadily. Currently our group includes > 40 researchers, 21 of which are PhD students and 7 are post docs. They represent widely different disciplines, such as neurosurgery, neurology, neuroanaesthesiology, neuroradiology, neuropsychology, clinical neurophysiology, psychiatry etc. I have conducted also large international research projects and am currently in a leading position in several trials. I have also experience on RCTs on the field. My group has a wide collaborative network both nationally and internationally, both in experimental and clinical research. Currently we have active research collaboration with ten national and 22 international (from 13 countries) research groups.
The research of our TBI has included topics from various disciplines, from psychiatry and neuropsychology to epidemiology, neurosurgery, and biochemistry. During the recent years we have mainly focused in three areas: 1) blood-based brain injury biomarkers, 2) novel brain imaging methodologies, and 3) multifaceted approach to diagnostic and prognostic modeling of TBI. We aim at solving clinical problems and conducting research which is easily transferred to clinical practice. We also collaborate with basic science in order to reveal brain injury mechanisms, since these help in understanding clinical phenomena and in developing new interventions. International collaboration and co-work are an essential part of our research policy.
Teaching about TBI has been a major part of my work for almost 20 years, both for medical students at the Turku University as well as nationally and internationally. Annually I have about 160 hrs of teaching for medical students.
- Post-Concussion Symptoms in Complicated vs. Uncomplicated Mild Traumatic Brain Injury Patients at Three and Six Months Post-Injury: Results from the CENTER-TBI Study (2019)
- Journal of Clinical Medicine
- Practitioners’ opinions on traumatic brain injury care pathways in Finland and France: different organizations, common issues (2019)
- Brain Injury
- Randomized Controlled Trials of Rehabilitation Services in the Post-acute Phase of Moderate and Severe Traumatic Brain Injury - A Systematic Review (2019)
- Frontiers in Neurology
- Risk factors for recurrent hematomas after surgery for acute traumatic subdural hematoma. (2019)
- World Neurosurgery
- Serum Neurofilament Light Is Elevated Differentially in Older Adults with Uncomplicated Mild Traumatic Brain Injuries (2019)
- Journal of Neurotrauma
- TBIcare Investigators' Response to Papa and Wang (doi: 10:1089/neu.2017.5030): Raising the Bar for Traumatic Brain Injury Biomarker Research: Methods Make a Difference (2019)
- Journal of Neurotrauma
- Univariate comparison of performance of different cerebrovascular reactivity indices for outcome association in adult TBI: a CENTER-TBI study (2019)
- Acta Neurochirurgica
- Variation in guideline implementation and adherence regarding severe traumatic brain injury treatment: a CENTER-TBI survey study in Europe (2019)
- World Neurosurgery
- Variation in neurosurgical management of traumatic brain injury: a survey in 68 centers participating in the CENTER-TBI study (2019)
- Acta Neurochirurgica
- Brain Cholinergic Function and Response to Rivastigmine in Patients With Chronic Sequels of Traumatic Brain Injury: A PET Study (2018)
- Journal of Head Trauma Rehabilitation
- Brain death and postmortem organ donation: report of a questionnaire from the CENTER-TBI study (2018)
- Critical Care
- Comparing disability between traumatic brain injury and spinal cord injury using the 12-item WHODAS 2.0 and the WHO minimal generic data set covering functioning and health (2018)
- Clinical Rehabilitation
- Comparison of Performance of Different Optimal Cerebral Perfusion Pressure Parameters for Outcome Prediction in Adult Traumatic Brain Injury: A Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study (2018)
- Journal of Neurotrauma
- Connectivity analysis of full montage EEG in traumatic brain injury patients in the ICU (2018)
- IFMBE proceedings
- Cranioplasty After Severe Traumatic Brain Injury: Effects of Trauma and Patient Recovery on Cranioplasty Outcome (2018)
- Frontiers in Neurology
- Digital Gaming for Improving the Functioning of People With Traumatic Brain Injury: Randomized Clinical Feasibility Study (2018)
- Journal of Medical Internet Research
- Emergency department overcrowding: a survey among European neurotrauma centres (2018)
- Emergency Medicine Journal
- Mortality after traumatic brain injury and the effect of posttraumatic epilepsy (2018)
- Neurology
- Prehospital Trauma Care among 68 European Neurotrauma Centers: Results of the CENTER-TBI Provider Profiling Questionnaires (2018)
- Journal of Neurotrauma
- Quantitative EEG parameters for prediction of outcome in severe traumatic brain injury: Development study (2018)
- Clinical EEG and Neuroscience