Olli Tenovuo
MD, PhD, Prof. of Neurotraumatology
Department of Neurosciences ollten@utu.fi |
traumatic brain injury; rehabilitation; biomarkers; imaging
Pathophysiology, diagnostics, treatment, and prognosis of traumatic brain injury
I have a long and profound experience in the field of traumatic brain injuries (TBIs), both clinically and scientifically. Patients with TBI of different severities have been my main clinical interest since early 1990’s, and during the years I have treated about 6 000 patients with TBI. Since 1996 I have led a multidisciplinary research group on TBIs, which has expanded steadily. Currently our group includes > 40 researchers, 21 of which are PhD students and 7 are post docs. They represent widely different disciplines, such as neurosurgery, neurology, neuroanaesthesiology, neuroradiology, neuropsychology, clinical neurophysiology, psychiatry etc. I have conducted also large international research projects and am currently in a leading position in several trials. I have also experience on RCTs on the field. My group has a wide collaborative network both nationally and internationally, both in experimental and clinical research. Currently we have active research collaboration with ten national and 22 international (from 13 countries) research groups.
The research of our TBI has included topics from various disciplines, from psychiatry and neuropsychology to epidemiology, neurosurgery, and biochemistry. During the recent years we have mainly focused in three areas: 1) blood-based brain injury biomarkers, 2) novel brain imaging methodologies, and 3) multifaceted approach to diagnostic and prognostic modeling of TBI. We aim at solving clinical problems and conducting research which is easily transferred to clinical practice. We also collaborate with basic science in order to reveal brain injury mechanisms, since these help in understanding clinical phenomena and in developing new interventions. International collaboration and co-work are an essential part of our research policy.
Teaching about TBI has been a major part of my work for almost 20 years, both for medical students at the Turku University as well as nationally and internationally. Annually I have about 160 hrs of teaching for medical students.
- Socioeconomic Consequences (2020) Management of Severe Traumatic Brain Injury Tenovuo Olli, Majdan Marek, Andelic Nada
- Statistical Cerebrovascular Reactivity Signal Properties after Secondary Decompressive Craniectomy in Traumatic Brain Injury: A CENTER-TBI Pilot Analysis (2020)
- Journal of Neurotrauma
- Systemic markers of injury and injury response are not associated with impaired cerebrovascular reactivity in adult TBI: A CENTER-TBI study (2020)
- Journal of Neurotrauma
- The Effect of Temperature Increases on Brain Tissue Oxygen Tension in Patients with Traumatic Brain Injury: A Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Substudy (2020)
- Therapeutic hypothermia and temperature management
- Toward a New Multi-Dimensional Classification of Traumatic Brain Injury: A Collaborative European NeuroTrauma Effectiveness Research for Traumatic Brain Injury Study (2020)
- Journal of Neurotrauma
- Tracheal intubation in traumatic brain injury: a multicentre prospective observational study (2020)
- British Journal of Anaesthesia
- Tracheostomy practice and timing in traumatic brain-injured patients: a CENTER-TBI study (2020)
- Intensive Care Medicine
- Understanding the relationship between cognitive performance and function in daily life after traumatic brain injury (2020)
- Journal of Neurology, Neurosurgery and Psychiatry
- Variation in the practice of tracheal intubation in Europe after traumatic brain injury: a prospective cohort study (2020)
- Anaesthesia
- Volume change in frontal cholinergic structures after traumatic brain injury and cognitive outcome (2020)
- Frontiers in Neurology
- A Decision Support System for Diagnostics and Treatment Planning in Traumatic Brain Injury (2019)
- IEEE Journal of Biomedical and Health Informatics
- Association between parent mental health and paediatric TBI: epidemiological observations from the 1987 Finnish Birth Cohort (2019)
- Injury Prevention
- Case-mix, care pathways, and outcomes in patients with traumatic brain injury in CENTER-TBI: a European prospective, multicentre, longitudinal, cohort study (2019)
- Lancet Neurology
- Central versus Local Radiological Reading of Acute Computed Tomography Characteristics in Multi-Center Traumatic Brain Injury Research (2019)
- Journal of Neurotrauma
- Cerebrovascular reactivity is not associated with therapeutic intensity in adult traumatic brain injury: a CENTER-TBI analysis (2019)
- Acta Neurochirurgica
- Compensatory-reserve-weighted intracranial pressure versus intracranial pressure for outcome association in adult traumatic brain injury: a CENTER-TBI validation study (2019)
- Acta Neurochirurgica
- Correlation of blood biomarkers and biomarker panels with traumatic findings on computed tomography after traumatic brain injury (2019)
- Journal of Neurotrauma
- Development of a quality indicator set to measure and improve quality of ICU care for patients with traumatic brain injury (2019)
- Critical Care
- Early Levels of Glial Fibrillary Acidic Protein and Neurofilament Light Protein in Predicting the Outcome of Mild Traumatic Brain Injury (2019)
- Journal of Neurotrauma
- Head trauma in sports – clinical characteristics, epidemiology and biomarkers (2019)
- Journal of Internal Medicine