Olli Tenovuo
MD, PhD, Prof. of Neurotraumatology
Department of Neurosciences ollten@utu.fi |
traumatic brain injury; rehabilitation; biomarkers; imaging
Pathophysiology, diagnostics, treatment, and prognosis of traumatic brain injury
I have a long and profound experience in the field of traumatic brain injuries (TBIs), both clinically and scientifically. Patients with TBI of different severities have been my main clinical interest since early 1990’s, and during the years I have treated about 6 000 patients with TBI. Since 1996 I have led a multidisciplinary research group on TBIs, which has expanded steadily. Currently our group includes > 40 researchers, 21 of which are PhD students and 7 are post docs. They represent widely different disciplines, such as neurosurgery, neurology, neuroanaesthesiology, neuroradiology, neuropsychology, clinical neurophysiology, psychiatry etc. I have conducted also large international research projects and am currently in a leading position in several trials. I have also experience on RCTs on the field. My group has a wide collaborative network both nationally and internationally, both in experimental and clinical research. Currently we have active research collaboration with ten national and 22 international (from 13 countries) research groups.
The research of our TBI has included topics from various disciplines, from psychiatry and neuropsychology to epidemiology, neurosurgery, and biochemistry. During the recent years we have mainly focused in three areas: 1) blood-based brain injury biomarkers, 2) novel brain imaging methodologies, and 3) multifaceted approach to diagnostic and prognostic modeling of TBI. We aim at solving clinical problems and conducting research which is easily transferred to clinical practice. We also collaborate with basic science in order to reveal brain injury mechanisms, since these help in understanding clinical phenomena and in developing new interventions. International collaboration and co-work are an essential part of our research policy.
Teaching about TBI has been a major part of my work for almost 20 years, both for medical students at the Turku University as well as nationally and internationally. Annually I have about 160 hrs of teaching for medical students.
- Impact of duration and magnitude of raised intracranial pressure on outcome after severe traumatic brain injury: A CENTER-TBI high-resolution group study (2020)
- PLoS ONE
- Incidence, Risk Factors, and Effects on Outcome of Ventilator-Associated Pneumonia in Patients With Traumatic Brain Injury: Analysis of a Large, Multicenter, Prospective, Observational Longitudinal Study (2020)
- Chest
Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Participants and Investigators - Influence of Concomitant Extracranial Injury on Functional and Cognitive Recovery From Mild Versus Moderate to Severe Traumatic Brain Injury (2020)
- Journal of Head Trauma Rehabilitation
- Influence of Sociodemographic, Premorbid, and Injury-Related Factors on Post-Concussion Symptoms after Traumatic Brain Injury (2020)
- Journal of Clinical Medicine
- Informed consent procedures in patients with an acute inability to provide informed consent: Policy and practice in the CENTER-TBI study (2020)
- Journal of Critical Care
- Injury Causes and Severity in Pediatric Traumatic Brain Injury Patients Admitted to the Ward or Intensive Care Unit: A Collaborative European Neurotrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study (2020)
- Frontiers in Neurology
- Integrative Analysis of Circulating Metabolite Profiles and Magnetic Resonance Imaging Metrics in Patients with Traumatic Brain Injury (2020)
- International Journal of Molecular Sciences
- Interleukin 10 and Heart Fatty Acid-Binding Protein as Early Outcome Predictors in Patients With Traumatic Brain Injury (2020)
- Frontiers in Neurology
- Long-Term Follow-Up (2020) Management of Severe Traumatic Brain Injury Tenovuo Olli, Andelic Nada, Sigurdardottir Solrun
- Low-resolution pressure reactivity index and its derived optimal cerebral perfusion pressure in adult traumatic brain injury: a CENTER-TBI study (2020)
- Critical Care
- Machine learning algorithms performed no better than regression models for prognostication in traumatic brain injury (2020)
- Journal of Clinical Epidemiology
- Mild traumatic brain injury recovery: a growth curve modelling analysis over 2 years (2020)
- Journal of Neurology
- Outcome Prediction after Moderate and Severe Traumatic Brain Injury: External Validation of Two Established Prognostic Models in 1742 European Patients (2020)
- Journal of Neurotrauma
- Pathophysiology of Severe Traumatic Brain Injury (2020) Management of Severe Traumatic Brain Injury Marklund Niklas, Tenovuo Olli
- Predictors of Access to Rehabilitation in the Year Following Traumatic Brain Injury: A European Prospective and Multicenter Study (2020)
- Neurorehabilitation and Neural Repair
- Prehospital Management of Traumatic Brain Injury across Europe: A CENTER-TBI Study (2020)
- Prehospital Emergency Care
- Prognostic Validation of the NINDS Common Data Elements for the Radiologic Reporting of Acute Traumatic Brain Injuries: A CENTER-TBI Study (2020)
- Journal of Neurotrauma
- Quality indicators for patients with traumatic brain injury in European intensive care units: a CENTER-TBI study (2020)
- Critical Care
- Reference Values of the QOLIBRI from General Population Samples in the United Kingdom and The Netherlands (2020)
- Journal of Clinical Medicine
- Rehabilitation After Severe TBI (2020) Management of Severe Traumatic Brain Injury Andelic Nada, Sigurdardottir Solrun, Tenovuo Olli