Olli Tenovuo
MD, PhD, Prof. of Neurotraumatology
Department of Neurosciences ollten@utu.fi |
traumatic brain injury; rehabilitation; biomarkers; imaging
Pathophysiology, diagnostics, treatment, and prognosis of traumatic brain injury
I have a long and profound experience in the field of traumatic brain injuries (TBIs), both clinically and scientifically. Patients with TBI of different severities have been my main clinical interest since early 1990’s, and during the years I have treated about 6 000 patients with TBI. Since 1996 I have led a multidisciplinary research group on TBIs, which has expanded steadily. Currently our group includes > 40 researchers, 21 of which are PhD students and 7 are post docs. They represent widely different disciplines, such as neurosurgery, neurology, neuroanaesthesiology, neuroradiology, neuropsychology, clinical neurophysiology, psychiatry etc. I have conducted also large international research projects and am currently in a leading position in several trials. I have also experience on RCTs on the field. My group has a wide collaborative network both nationally and internationally, both in experimental and clinical research. Currently we have active research collaboration with ten national and 22 international (from 13 countries) research groups.
The research of our TBI has included topics from various disciplines, from psychiatry and neuropsychology to epidemiology, neurosurgery, and biochemistry. During the recent years we have mainly focused in three areas: 1) blood-based brain injury biomarkers, 2) novel brain imaging methodologies, and 3) multifaceted approach to diagnostic and prognostic modeling of TBI. We aim at solving clinical problems and conducting research which is easily transferred to clinical practice. We also collaborate with basic science in order to reveal brain injury mechanisms, since these help in understanding clinical phenomena and in developing new interventions. International collaboration and co-work are an essential part of our research policy.
Teaching about TBI has been a major part of my work for almost 20 years, both for medical students at the Turku University as well as nationally and internationally. Annually I have about 160 hrs of teaching for medical students.
- Perceived Communication Abilities after Moderate to Severe Traumatic Diffuse Axonal Injury (2023)
- Brain Injury
- Plasma neurofilament light admission levels and development of axonal pathology in mild traumatic brain injury (2023)
- BMC Neurology
- The lower limit of reactivity as a potential individualised cerebral perfusion pressure target in traumatic brain injury: a CENTER-TBI high-resolution sub-study analysis (2023)
- Critical Care
- Trajectories of Interleukin 10 and Heart Fatty Acid-Binding Protein Levels in Traumatic Brain Injury Patients with or without Extracranial Injuries (2023)
- Frontiers in Neurology
- Blood-based biomarkers and traumatic brain injury-A clinical perspective (2022)
- Acta Neurologica Scandinavica
- Cerebral Microbleeds and Structural White Matter Integrity in Patients With Traumatic Brain Injury-A Diffusion Tensor Imaging Study (2022)
- Frontiers in Neurology
- Cognitive-linguistic skills of adults who suffered a diffuse axonal injury in childhood or youth (2022) Raukola-Lindblom Marjaana, Ljungqvist Linda, Kurki Timo, Hämäläinen Heikki, Tenovuo Olli
- Post-acute blood biomarkers and disease progression in traumatic brain injury (2022)
- Brain
- Potential of heart fatty-acid binding protein, neurofilament light, interleukin-10 and S100 calcium-binding protein B in the acute diagnostics and severity assessment of traumatic brain injury (2022)
- Emergency Medicine Journal
- Rehabilitation and outcomes after complicated vs uncomplicated mild TBI: results from the CENTER-TBI study (2022)
- BMC Health Services Research
- Serum metabolome associated with severity of acute traumatic brain injury (2022)
- Nature Communications
- Structural Brain Connectivity Correlates with Outcome in Mild Traumatic Brain Injury (2022)
- Journal of Neurotrauma
- Traumatic brain injury: progress and challenges in prevention, clinical care, and research (2022)
- Lancet Neurology
- Validation of cross-sectional and longitudinal ComBat harmonization methods for magnetic resonance imaging data on a travelling subject cohort (2022)
- Neuroimage: reports
- Acute Kidney Injury in Traumatic Brain Injury Patients: Results From the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Study (2021)
- Critical Care Medicine
- Analysis of Cardio-Cerebral Crosstalk Events in an Adult Cohort from the CENTER-TBI Study (2021) Intracranial Pressure and Neuromonitoring XVII Dimitri Giovanna Maria, Beqiri Erta, Czosnyka Marek, Ercole Ari, Smielewski Peter, Lio Pietro; CENTER-TBI High Resolution Substudy Participants and Investigators
- Assessing the Severity of Traumatic Brain Injury-Time for a Change? (2021)
- Journal of Clinical Medicine
- Association between Physiological Signal Complexity and Outcomes in Moderate and Severe Traumatic Brain Injury: A CENTER-TBI Exploratory Analysis of Multi-Scale Entropy (2021)
- Journal of Neurotrauma
- Biomarkers in Traumatic Brain Injury (2021) Traumatic Brain Injury Posti Jussi P, Tenovuo Olli
- Brain Temperature Influences Intracranial Pressure and Cerebral Perfusion Pressure After Traumatic Brain Injury: A CENTER-TBI Study (2021)
- Neurocritical Care