Olli Tenovuo
MD, PhD, Prof. of Neurotraumatology
Department of Neurosciences ollten@utu.fi |
traumatic brain injury; rehabilitation; biomarkers; imaging
Pathophysiology, diagnostics, treatment, and prognosis of traumatic brain injury
I have a long and profound experience in the field of traumatic brain injuries (TBIs), both clinically and scientifically. Patients with TBI of different severities have been my main clinical interest since early 1990’s, and during the years I have treated about 6 000 patients with TBI. Since 1996 I have led a multidisciplinary research group on TBIs, which has expanded steadily. Currently our group includes > 40 researchers, 21 of which are PhD students and 7 are post docs. They represent widely different disciplines, such as neurosurgery, neurology, neuroanaesthesiology, neuroradiology, neuropsychology, clinical neurophysiology, psychiatry etc. I have conducted also large international research projects and am currently in a leading position in several trials. I have also experience on RCTs on the field. My group has a wide collaborative network both nationally and internationally, both in experimental and clinical research. Currently we have active research collaboration with ten national and 22 international (from 13 countries) research groups.
The research of our TBI has included topics from various disciplines, from psychiatry and neuropsychology to epidemiology, neurosurgery, and biochemistry. During the recent years we have mainly focused in three areas: 1) blood-based brain injury biomarkers, 2) novel brain imaging methodologies, and 3) multifaceted approach to diagnostic and prognostic modeling of TBI. We aim at solving clinical problems and conducting research which is easily transferred to clinical practice. We also collaborate with basic science in order to reveal brain injury mechanisms, since these help in understanding clinical phenomena and in developing new interventions. International collaboration and co-work are an essential part of our research policy.
Teaching about TBI has been a major part of my work for almost 20 years, both for medical students at the Turku University as well as nationally and internationally. Annually I have about 160 hrs of teaching for medical students.
- Association of injury severity, MRI results and ApoE genotype with one-year outcome in traumatic brain injury (2009)
- Brain Injury
- Attentional and depressive symptoms in chronic phase after traumatic brain injury (2009)
- Brain Injury
- Reliability of diagnosis of traumatic brain injury by computed tomography in acute phase (2009)
- Journal of Neurotrauma
- Posterior cortical atrophy: a rare form of dementia with in vivo evidence of amyloid-beta accumulation (2008)
- Journal of Alzheimer's Disease
- Aivovamman jälkitilan diagnostiikka ja arviointi (2007) Tenovuo O, Vataja R, Salonen O, Laaksonen R
- Central pain after brain trauma – a neglected problem in neglected victims. (2007)
- PAIN
- Clinical assessment of hemispatial neglect: evaluation of different measures and dimensions (2007)
- Clinical Neuropsychologist
- Differences and similarities between atypical facial pain and trigeminal neuropathic pain (2007)
- Neurology
- MRI changes and APOE genotype, a prospective one-year follow-up of traumatic brain injury: a pilot study (2007)
- Brain Injury
- Cholinergic treatment of traumatic brain injury (2006)
- Current Drug Therapy
- Functional brain imaging, clinical and neurophysiological outcome of visual rehabilitation in a chronic stroke patient. (2006)
- Restorative Neurology and Neuroscience
- Hippocampal volume, brain atrophy, and ApoE genotype after traumatic brain injury. (2006)
- Neurology
- Longitudinal cognitive changes in traumatic brain injury: a 30 year follow-up study (2006)
- Neurology
- MRI findings and axis I and II psychiatric disorders after traumatic brain injury: a 30-year retrospective follow-up study (2006)
- Psychiatry Research: Neuroimaging
- MR imaging of head trauma: visibility of contusions and other intraparenchymal injuries in early and late stage (2006)
- Brain Injury
- Outcome of traumatic brain injury after three decades - relationship to ApoE genotype (2006)
- Journal of Neurotrauma
- Pharmacological enhancement of cognitive and behavioral deficits after traumatic brain injury. (2006)
- Current Opinion in Neurology
- Alexithymia after traumatic brain injury: its relation to magnetic resonance imaging findings and psychiatric disorders (2005)
- Psychosomatic Medicine
- Central acetylcholinesterase inhibitors in the treatment of chronic traumatic brain injury – clinical experience in 111 patients (2005)
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Cognitive functions in relation to MRI findings 30 years after traumatic brain injury (2005)
- Brain Injury