Xiang-Guo Li
Assistant Professor
Turku PET Centre, University of Turku xiali@utu.fi Kiinamyllynkatu 10 Turku ORCID-tunniste: https://orcid.org/0000-0002-9118-7223 |
Radiochemistry, Radiopharmaceuticals, PET imaging, New drug development
Radiochemistry, Radiopharmaceuticals, InFLAMES Flagship
I am a radiochemist and medicinal chemist working at Turku PET Centre, University of Turku, Finland. I received my PhD degree from the Institute of Biomedicine, Faculty of Medicine, University of Turku, in 2008. Then I was at a Post-doctoral position funded by the Academy of Finland during 2010-2012. I received my Docentship in 2012 from University of Turku. Since 2013, I have been working at Turku PET Centre. At present, I work as an Assistant Professor in Radiochemistry, and Principal Investigator in the InFLAMES Research Flagship.
Basic research in radiochemistry including methodological development for radiosynthesis and radiolabeling techniques. We have been able to radiolabel many types of molecules including small organic compounds, peptides, antibody and antibody fragments, oligonucleotides, oligosaccharides etc.
Development of new radiopharmaceuticals for PET imaging of inflammatory diseases and immunological diseases.
The radiolabeled molecules are for imaging diseases or for studying disease machanisms with PET.
I teach in the courses of Radiopharmaceutical Chemistry, Radiolabeling techniques, Measuring techniques in radiochemistry, PET Basics, and supervise BSc, MSc and PhD students.
- Comparison of Somatostatin Receptor 2-Targeting PET Tracers in the Detection of Mouse Atherosclerotic Plaques (2016)
- Molecular Imaging and Biology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Enabling [18F]-bicyclo[6.1.0]nonyne for oligonucleotide conjugation for positron emission tomography applications: [18F]-anti-microRNA-21 as an example (2015)
- Chemical Communications
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Detection of atherosclerotic plaques with a novel vascular adhesion protein-1 targeting [18F]FDR-Siglec-9 peptide (2014)
- Journal of Nuclear Medicine
(O2 Muu julkaisu ) - Feasibility of experimental BT4C glioma models for somatostatin receptor 2-targeted therapies. (2014)
- Acta Oncologica
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Using 5-deoxy-5-[F-18] fluororibose to glycosylate peptides for positron emission tomography (2014)
- Nature Protocols
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Translating the concept of peptide labeling with 5-deoxy-5-[F-18] fluororibose into preclinical practice: F-18-labeling of Siglec-9 peptide for PET imaging of inflammation (2013)
- Chemical Communications
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - [18F]-5-Fluoro-5-deoxyribose, an efficient peptide bioconjugation ligand for positron emission tomography (PET) imaging (2012)
- Chemical Communications
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - New biocatalytic route for the production of enantioenriched b-alanine derivatives starting from 5- and 6-monosubstituted dihydrouracils (2012)
- Process Biochemistry
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Oxime formation for fluorine-18 labeling of peptides and proteins for positron emission tomography (PET) imaging: A review (2012)
- Journal of Fluorine Chemistry
(A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä) - Candida antarctica Lipase B in a Chemoenzymatic Route to Cyclic ?-Quaternary ?-Amino Acid Enantiomers (2011)
- European Journal of Organic Chemistry
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Fluorinase mediated chemoenzymatic synthesis of [18F]-fluoroacetate (2010)
- Chemical Communications
(A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä)