Xiang-Guo Li
Assistant Professor
Turku PET Centre, University of Turku xiali@utu.fi Kiinamyllynkatu 10 Turku ORCID-tunniste: https://orcid.org/0000-0002-9118-7223 |
Radiochemistry, Radiopharmaceuticals, PET imaging, New drug development
Radiochemistry, Radiopharmaceuticals, InFLAMES Flagship
I am a radiochemist and medicinal chemist working at Turku PET Centre, University of Turku, Finland. I received my PhD degree from the Institute of Biomedicine, Faculty of Medicine, University of Turku, in 2008. Then I was at a Post-doctoral position funded by the Academy of Finland during 2010-2012. I received my Docentship in 2012 from University of Turku. Since 2013, I have been working at Turku PET Centre. At present, I work as an Assistant Professor in Radiochemistry, and Principal Investigator in the InFLAMES Research Flagship.
Basic research in radiochemistry including methodological development for radiosynthesis and radiolabeling techniques. We have been able to radiolabel many types of molecules including small organic compounds, peptides, antibody and antibody fragments, oligonucleotides, oligosaccharides etc.
Development of new radiopharmaceuticals for PET imaging of inflammatory diseases and immunological diseases.
The radiolabeled molecules are for imaging diseases or for studying disease machanisms with PET.
I teach in the courses of Radiopharmaceutical Chemistry, Radiolabeling techniques, Measuring techniques in radiochemistry, PET Basics, and supervise BSc, MSc and PhD students.
- Macrophage mannose receptor CD206-targeted PET imaging in experimental acute myocardial infarction (2025)
- EJNMMI Research
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - The relationships between non-invasive myocardial work indices, myocardial blood flow and viability determined by PET (2025)
- EHJ Cardiovascular Imaging / European Heart Journal - Cardiovascular Imaging
(Abstrakti) - Trajectories and determinants of myocardial work indices in patients with acute myocardial infarction after primary percutaneous coronary intervention (2025)
- EHJ Cardiovascular Imaging / European Heart Journal - Cardiovascular Imaging
(Abstrakti) - Analysis of sleep apnea research with a special focus on the use of positron emission tomography as a study tool (2024)
- Sleep Medicine Reviews
(A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä) - Evaluation of 18F FOL a PET tracer targeting folate receptor beta in a rat model of myocardial infarction (2024)
- European Heart Journal
(Abstrakti) - Highlight selection of radiochemistry and radiopharmacy developments by editorial board (2024)
- EJNMMI Radiopharmacy and Chemistry
(B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä ) - Imaging of Myocardial αvβ3Integrin Expression for Evaluation of Myocardial Injury After Acute Myocardial Infarction (2024)
- Journal of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Macrophage mannose receptor CD206 targeting of fluoride‐18 labeled mannosylated dextran: A validation study in mice (2024)
- European Journal of Nuclear Medicine and Molecular Imaging
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Mannose receptor independent uptake of transmembrane glycocluster immunostimulant TADM by macrophages (2024)
- Carbohydrate Research
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Switching the Chemoselectivity in the Preparation of [18F]FNA-N-CooP, a Free Thiol-Containing Peptide for Targeted Positron Emission Tomography Imaging of Fatty Acid Binding Protein 3 (2024)
- Molecular Pharmaceutics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Voices in Molecular Pharmaceutics: Meet Professor Xiang-Guo Li, an Expert in Radiopharmaceutical Chemistry and Positron Emission Tomography for Improved Imaging of Immunological Disorders and Brain Tumors (2024)
- Molecular Pharmaceutics
(B1 Vertaisarvioitu muu artikkeli (esim. pääkirjoitus, letter, comment) tieteellisessä lehdessä) - Aluminum Fluoride-18 Labeled Mannosylated Dextran: Radiosynthesis and Initial Preclinical Positron Emission Tomography Studies (2023)
- Molecular Imaging and Biology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Detection of Intestinal Inflammation by Vascular Adhesion Protein-1-Targeted [68Ga]Ga-DOTA-Siglec-9 Positron Emission Tomography in Murine Models of Inflammatory Bowel Disease (2023)
- Molecular Imaging and Biology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Efficient radiosynthesis of a new folate receptor-targeting PET tracer, [18F]fluoronicotinic acid labeled folate, for imaging lung fibrosis (2023)
- Nuclear Medicine and Biology
(O2 Muu julkaisu ) - High folate receptor expression in gliomas can be detected in vivo using folate-based positron emission tomography with high tumor-to-brain uptake ratio divulging potential future targeting possibilities (2023)
- Frontiers in Immunology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Macrophage Hitchhiking Nanoparticles for the Treatment of Myocardial Infarction: An In Vitro and In Vivo Study (2023)
- Advanced Functional Materials
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Mannose Receptor (CD206) Targeting with Aluminum Fluoride-18 Labeled Mannosylated Dextran (2023)
- Nuclear Medicine and Biology
(O2 Muu julkaisu ) - Pretargeted PET imaging of trans-cyclooctene functionalized spherical nucleic acids (2023)
- Nuclear Medicine and Biology
(O2 Muu julkaisu ) - Targeting mammary-derived growth inhibitor for positron emission tomography imaging of breast cancer brain metastasis (2023)
- Nuclear Medicine and Biology
Airaksinen Anu, Laakkonen Pirjo, Li Xiang-Guo
(O2 Muu julkaisu ) - Tetrazine Glycoconjugate for Pretargeted Positron Emission Tomography Imaging of trans-Cyclooctene-Functionalized Molecular Spherical Nucleic Acids (2023)
- ACS Omega
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )