Xiang-Guo Li
Associate Professor
Turku PET Centre, University of Turku xiali@utu.fi Kiinamyllynkatu 10 Turku : https://orcid.org/0000-0002-9118-7223 |
Radiochemistry, Radiopharmaceuticals, PET imaging, New drug development
Radiochemistry, Radiopharmaceuticals, InFLAMES Flagship
I am a radiochemist and medicinal chemist working at Turku PET Centre, University of Turku, Finland. I received my PhD degree from the Institute of Biomedicine, Faculty of Medicine, University of Turku, in 2008. Then I was at a Post-doctoral position funded by the Academy of Finland during 2010-2012. I received my Docentship in 2012 from University of Turku. Since 2013, I have been working at Turku PET Centre. At present, I work as an Assistant Professor in Radiochemistry, and Principal Investigator in the InFLAMES Research Flagship.
Basic research in radiochemistry including methodological development for radiosynthesis and radiolabeling techniques. We have been able to radiolabel many types of molecules including small organic compounds, peptides, antibody and antibody fragments, oligonucleotides, oligosaccharides etc.
Development of new radiopharmaceuticals for PET imaging of inflammatory diseases and immunological diseases.
The radiolabeled molecules are for imaging diseases or for studying disease machanisms with PET.
I teach in the courses of Radiopharmaceutical Chemistry, Radiolabeling techniques, Measuring techniques in radiochemistry, PET Basics, and supervise BSc, MSc and PhD students.
- Vascular adhesion protein-1-targeted PET imaging in autoimmune myocarditis (2023)
- Journal of Nuclear Cardiology
- 68Ga-Citrate Positron Emission Tomography of Healthy Men: Whole-Body Biodistribution Kinetics and Radiation Dose Estimates (2022)
- Journal of Nuclear Medicine
- Comparing Folate Receptor β Targeting Tracers in Experimental Myocarditis Model (2022)
- European Journal of Nuclear Medicine and Molecular Imaging
- Corrigendum: Exploiting Glutamine Consumption in Atherosclerotic Lesions by Positron Emission Tomography Tracer (2S,4R)-4-18F-Fluoroglutamine(Front. Immunol., (2022), 13, (821423), 10.3389/fimmu.2022.821423) (2022)
- Frontiers in Immunology
- Exploiting Glutamine Consumption in Atherosclerotic Lesions by Positron Emission Tomography Tracer (2S,4R)-4-F-18-Fluoroglutamine (2022)
- Frontiers in Immunology
- Exploring macrophage mannose receptor expression after myocardial infarction by Al[18F]F-NOTA-DCM positron emission tomography (2022)
- European Heart Journal
- [Ga-68]Ga-DOTA-Siglec-9 Detects Pharmacodynamic Changes of FAP-Targeted IL2 Variant Immunotherapy in B16-FAP Melanoma Mice (2022)
- Frontiers in Immunology
- O-59 - Radiolabeling and biological evaluation of functionalized spherical nucleic acids (2022)
- Nuclear Medicine and Biology
- PET radiopharmaceuticals for imaging inflammatory diseases (2022) Nuclear Medicine and Molecular Imaging Li Xiang-Guo, Velikyan Irina, Viitanen Riikka, Roivainen Anne
- Preclinical Evaluation of a Humanized Antibody Against Common Lymphatic Endothelial and Vascular Endothelial Receptor-1, 89Zr-Desferrioxamine-Bexmarilimab, in a Rabbit Model of Renal Fibrosis (2022)
- Journal of Nuclear Medicine
- Radiosynthesis and biological evaluation of [18F]CooP: a brain-homing peptide for imaging glioblastomas using positron emission tomography (2022)
- Nuclear Medicine and Biology
- Radiosynthesis of new PET tracer targeting macrophage mannose receptor (2022) Andriana Putri, Palani Senthil, Fair-Mäkelä Ruth, Makrypidi Konstantina, Liljenbäck Heidi, Kärnä Salli, Salmi Marko, Pirmettis Ioannis, Saraste Antti, Li Xiang-Guo, Roivainen Anne
- Targetting folate receptor-β expressing macrophages by 18F-labelled folate PET radiotracer in rat model of myocardial infarction (2022)
- European Journal of Nuclear Medicine and Molecular Imaging
- Association between [Ga-68]NODAGA-RGDyK uptake and dynamics of angiogenesis in a human cell-based 3D model (2021)
- Molecular Biology Reports
- Biological evaluation of [18F]FDG-Tz as a tracer candidate for pretargeted PET imaging (2021)
- Nuclear Medicine and Biology
- Comparison of: (2S,4R)-4-[F-18]Fluoroglutamine, [C-11]Methionine, and 2-Deoxy-2-[F-18]Fluoro-D-Glucose and Two Small-Animal PET/CT Systems Imaging Rat Gliomas (2021)
- Frontiers in Oncology
- Efficacy and tolerability of folate-aminopterin therapy in a rat focal model of multiple sclerosis (2021)
- Journal of Neuroinflammation
- Evaluation of [68Ga]Ga-NODAGA-RGD for PET Imaging of Rat Autoimmune Myocarditis (2021)
- Frontiers in Medicine
- Evaluation of glucagon-like peptide-1 receptor expression in nondiabetic and diabetic atherosclerotic mice using PET tracer 68Ga-NODAGA-exendin-4 (2021)
- American Journal of Physiology : Endocrinology and Metabolism
- First-in-Human Study of 68 Ga-DOTA-Siglec-9, PET Ligand Targeting Vascular Adhesion Protein 1 (2021)
- Journal of Nuclear Medicine