Xiang-Guo Li
Assistant Professor
Turku PET Centre, University of Turku xiali@utu.fi Kiinamyllynkatu 10 Turku ORCID identifier: https://orcid.org/0000-0002-9118-7223 |
Radiochemistry, Radiopharmaceuticals, PET imaging, New drug development
Radiochemistry, Radiopharmaceuticals, InFLAMES Flagship
I am a radiochemist and medicinal chemist working at Turku PET Centre, University of Turku, Finland. I received my PhD degree from the Institute of Biomedicine, Faculty of Medicine, University of Turku, in 2008. Then I was at a Post-doctoral position funded by the Academy of Finland during 2010-2012. I received my Docentship in 2012 from University of Turku. Since 2013, I have been working at Turku PET Centre. At present, I work as an Assistant Professor in Radiochemistry, and Principal Investigator in the InFLAMES Research Flagship.
Basic research in radiochemistry including methodological development for radiosynthesis and radiolabeling techniques. We have been able to radiolabel many types of molecules including small organic compounds, peptides, antibody and antibody fragments, oligonucleotides, oligosaccharides etc.
Development of new radiopharmaceuticals for PET imaging of inflammatory diseases and immunological diseases.
The radiolabeled molecules are for imaging diseases or for studying disease machanisms with PET.
I teach in the courses of Radiopharmaceutical Chemistry, Radiolabeling techniques, Measuring techniques in radiochemistry, PET Basics, and supervise BSc, MSc and PhD students.
- Highlight selection of radiochemistry and radiopharmacy developments by editorial board (2021)
- EJNMMI Radiopharmacy and Chemistry
(B1 Non-refereed article in a scientific journal) - Highlight selection of radiochemistry and radiopharmacy developments by editorial board (January-June 2020) (2021)
- EJNMMI Radiopharmacy and Chemistry
(B1 Non-refereed article in a scientific journal) - (2S, 4R)-4-[18F]Fluoroglutamine for In vivo PET Imaging of Glioma Xenografts in Mice: an Evaluation of Multiple Pharmacokinetic Models (2020)
- Molecular Imaging and Biology
(A1 Refereed original research article in a scientific journal) - Candida antarctica Lipase A-Based Enantiorecognition of a Highly Strained 4-Dibenzocyclooctynol (DIBO) Used for PET Imaging (2020)
- Molecules
(A1 Refereed original research article in a scientific journal) - Folate Receptor β Targeted PET Imaging of Macrophages in Autoimmune Myocarditis (2020)
- Journal of Nuclear Medicine
(A1 Refereed original research article in a scientific journal) - Glucagon-like peptide-1 receptor expression after myocardial infarction: Imaging study using [68Ga]NODAGA-exendin-4 positron emission tomography (2020)
- Journal of Nuclear Cardiology
(A1 Refereed original research article in a scientific journal) - In Vivo Imaging of Inflammation and Infection 2019 (2020)
- Contrast Media and Molecular Imaging
(B1 Non-refereed article in a scientific journal) - Radiosynthesis and preclinical evaluation of [68Ga]Ga-NOTA-folate for PET imaging of folate receptor β-positive macrophages (2020)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - Extrasynaptic δ‐GABAA receptors are high affinity muscimol receptors (2019)
- Journal of Neurochemistry
(A1 Refereed original research article in a scientific journal) - Folate receptor-targeted positron emission tomography of experimental autoimmune encephalomyelitis in rats (2019)
- Journal of Neuroinflammation
(A1 Refereed original research article in a scientific journal) - Safety Study of Single-Dose Intravenously Administered DOTA-Siglec-9 Peptide in Sprague Dawley Rats (2019)
- International Journal of Toxicology
(A1 Refereed original research article in a scientific journal) - Adventures in radiosynthesis of clinical grade [68Ga]Ga-DOTA-Siglec-9 (2018)
- RSC Advances
(A1 Refereed original research article in a scientific journal) - Aluminum fluoride-18 labeled folate enables in vivo detection of atherosclerotic plaque inflammation by positron emission tomography (2018)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - Evaluation of 68Ga-labeled peptide tracer for detection of gelatinase expression after myocardial infarction in rat (2018)
- Journal of Nuclear Cardiology
(A1 Refereed original research article in a scientific journal) - Exploring Alternative Radiolabeling Strategies for Sialic Acid-Binding Immunoglobulin-Like Lectin 9 Peptide: [68Ga]Ga- and [18F]AlF-NOTA-Siglec-9 (2018)
- Molecules
(A1 Refereed original research article in a scientific journal) - In Vivo Imaging of Inflammation and Infection (2018)
- Contrast Media and Molecular Imaging
(B1 Non-refereed article in a scientific journal) - 18-kDa translocator protein ligand 18F-FEMPA: Biodistribution and uptake into atherosclerotic plaques in mice (2017)
- Journal of Nuclear Cardiology
(A1 Refereed original research article in a scientific journal) - Comparison of Ga-68-DOTA-Siglec-9 and F-18-Fluorodeoxyribose-Siglec-9: Inflammation Imaging and Radiation Dosimetry (2017)
- Contrast Media and Molecular Imaging
(A1 Refereed original research article in a scientific journal) - 18F-Labeling of Mannan for Inflammation Research with Positron Emission Tomography (2016)
- ACS Medicinal Chemistry Letters
(A1 Refereed original research article in a scientific journal) - A new highly reactive and low lipophilicity fluorine-18 labeled tetrazine derivative for pretargeted PET imaging (2016)
- ACS Medicinal Chemistry Letters
(A1 Refereed original research article in a scientific journal)