Xiang-Guo Li
Associate Professor
Turku PET Centre, University of Turku xiali@utu.fi Kiinamyllynkatu 10 Turku ORCID identifier: https://orcid.org/0000-0002-9118-7223(external) Research team webpage(external) |
Radiochemistry, Radiopharmaceuticals, PET imaging, New drug development
Radiochemistry, Radiopharmaceuticals, InFLAMES Flagship
I am a radiochemist and medicinal chemist working at Turku PET Centre, University of Turku, Finland. I received my PhD degree from the Institute of Biomedicine, Faculty of Medicine, University of Turku, in 2008. Then I was at a Post-doctoral position funded by the Academy of Finland during 2010-2012. I received my Docentship in 2012 from University of Turku. Since 2013, I have been working at Turku PET Centre. At present, I work as an Assistant Professor in Radiochemistry, and Principal Investigator in the InFLAMES Research Flagship.
Basic research in radiochemistry including methodological development for radiosynthesis and radiolabeling techniques. We have been able to radiolabel many types of molecules including small organic compounds, peptides, antibody and antibody fragments, oligonucleotides, oligosaccharides etc.
Development of new radiopharmaceuticals for PET imaging of inflammatory diseases and immunological diseases.
The radiolabeled molecules are for imaging diseases or for studying disease machanisms with PET.
I teach in the courses of Radiopharmaceutical Chemistry, Radiolabeling techniques, Measuring techniques in radiochemistry, PET Basics, and supervise BSc, MSc and PhD students.
- Vascular adhesion protein-1-targeted PET imaging in autoimmune myocarditis (2023)
- Journal of Nuclear Cardiology
(A1 Refereed original research article in a scientific journal) - 68Ga-Citrate Positron Emission Tomography of Healthy Men: Whole-Body Biodistribution Kinetics and Radiation Dose Estimates (2022)
- Journal of Nuclear Medicine
(A1 Refereed original research article in a scientific journal) - Comparing Folate Receptor β Targeting Tracers in Experimental Myocarditis Model (2022)
- European Journal of Nuclear Medicine and Molecular Imaging
(Other publication) - Corrigendum: Exploiting Glutamine Consumption in Atherosclerotic Lesions by Positron Emission Tomography Tracer (2S,4R)-4-18F-Fluoroglutamine(Front. Immunol., (2022), 13, (821423), 10.3389/fimmu.2022.821423) (2022)
- Frontiers in Immunology
(Other publication) - Exploiting Glutamine Consumption in Atherosclerotic Lesions by Positron Emission Tomography Tracer (2S,4R)-4-F-18-Fluoroglutamine (2022)
- Frontiers in Immunology
(A1 Refereed original research article in a scientific journal) - Exploring macrophage mannose receptor expression after myocardial infarction by Al[18F]F-NOTA-DCM positron emission tomography (2022)
- European Heart Journal
(Other publication) - [Ga-68]Ga-DOTA-Siglec-9 Detects Pharmacodynamic Changes of FAP-Targeted IL2 Variant Immunotherapy in B16-FAP Melanoma Mice (2022)
- Frontiers in Immunology
(A1 Refereed original research article in a scientific journal) - O-59 - Radiolabeling and biological evaluation of functionalized spherical nucleic acids (2022)
- Nuclear Medicine and Biology
(Other publication) - PET radiopharmaceuticals for imaging inflammatory diseases (2022) Nuclear Medicine and Molecular Imaging Li Xiang-Guo, Velikyan Irina, Viitanen Riikka, Roivainen Anne
(A3 Refereed book chapter or chapter in a compilation book) - Preclinical Evaluation of a Humanized Antibody Against Common Lymphatic Endothelial and Vascular Endothelial Receptor-1, 89Zr-Desferrioxamine-Bexmarilimab, in a Rabbit Model of Renal Fibrosis (2022)
- Journal of Nuclear Medicine
(A1 Refereed original research article in a scientific journal) - Radiosynthesis and biological evaluation of [18F]CooP: a brain-homing peptide for imaging glioblastomas using positron emission tomography (2022)
- Nuclear Medicine and Biology
(Other publication) - Radiosynthesis of new PET tracer targeting macrophage mannose receptor (2022) Andriana Putri, Palani Senthil, Fair-Mäkelä Ruth, Makrypidi Konstantina, Liljenbäck Heidi, Kärnä Salli, Salmi Marko, Pirmettis Ioannis, Saraste Antti, Li Xiang-Guo, Roivainen Anne
(Other publication) - Targetting folate receptor-β expressing macrophages by 18F-labelled folate PET radiotracer in rat model of myocardial infarction (2022)
- European Journal of Nuclear Medicine and Molecular Imaging
(Other publication) - Association between [Ga-68]NODAGA-RGDyK uptake and dynamics of angiogenesis in a human cell-based 3D model (2021)
- Molecular Biology Reports
(A1 Refereed original research article in a scientific journal) - Biological evaluation of [18F]FDG-Tz as a tracer candidate for pretargeted PET imaging (2021)
- Nuclear Medicine and Biology
(Other publication) - Comparison of: (2S,4R)-4-[F-18]Fluoroglutamine, [C-11]Methionine, and 2-Deoxy-2-[F-18]Fluoro-D-Glucose and Two Small-Animal PET/CT Systems Imaging Rat Gliomas (2021)
- Frontiers in Oncology
(A1 Refereed original research article in a scientific journal) - Efficacy and tolerability of folate-aminopterin therapy in a rat focal model of multiple sclerosis (2021)
- Journal of Neuroinflammation
(A1 Refereed original research article in a scientific journal) - Evaluation of [68Ga]Ga-NODAGA-RGD for PET Imaging of Rat Autoimmune Myocarditis (2021)
- Frontiers in Medicine
(A1 Refereed original research article in a scientific journal) - Evaluation of glucagon-like peptide-1 receptor expression in nondiabetic and diabetic atherosclerotic mice using PET tracer 68Ga-NODAGA-exendin-4 (2021)
- American Journal of Physiology : Endocrinology and Metabolism
(A1 Refereed original research article in a scientific journal) - First-in-Human Study of 68 Ga-DOTA-Siglec-9, PET Ligand Targeting Vascular Adhesion Protein 1 (2021)
- Journal of Nuclear Medicine
(A1 Refereed original research article in a scientific journal)